Association of genetic variants in the FTO gene with metabolic syndrome: A case-control study in the Tunisian population

Elouej, Sahar; Nagara, Majdi; Attaoua, Redha; Sallem, O.K.; Rejeb, Imen; Hsouna, Sana; Lasram, Khaled; Chargui, Mariem; Jamoussi, H.; Turki, Z.; Kamoun, Inès; Belfki-Benali, Hanen; Abid, A.; Slama, C. Ben; Bahri, Sonia; Triki, Dalenda; Romdhane, Habiba Ben; Abdelhak, Sonia; Kéfi, Rym; Grigorescu, Florin

doi:10.1016/j.jdiacomp.2015.11.013

Cited by 18 publications

(12 citation statements)

References 47 publications

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“…2 The majority of more recent studies confirmed these findings. [3][4][5][6][7][8][9] However, mechanisms mediating the impact of the FTO gene on the development of obesity and related phenotypes remain unclear. Given that these polymorphic variants are intronic, it has been postulated that the FTO SNPs act via interactions with genes located in their close proximity.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the FTO gene polymorphisms inmale patients with metabolic syndrome

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Assessment of the FTO gene polymorphisms inmale patients with metabolic syndrome

et al. 2018

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“…Many previous researchers have studied the association between FTO gene variants and obesity and other metabolic parameters in different populations [13,14,19,56]. Common SNPs at candidate genes have been identified for obesity.…”

Section: Resultsmentioning

confidence: 99%

“…The results of that study showed an Table 4 Pearson Chi-square test between the two alleles and the three genotypes with the different biochemical parameters among the 186 female students. association of the gene with diabetes, higher fasting glucose levels, and high blood pressure [19]. In Egypt, the association between the rs9939609 variant of the FTO gene and polycystic ovary syndrome (PCOS) was examined in women because the phenotype of polycystic ovary syndrome (PCOS) overlaps with obesity.…”

Section: Resultsmentioning

confidence: 99%

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Genetic, dietary, and non-dietary risk factors of obesity among preparatory-year female students at Taibah University, Saudi Arabia

Nashar

Alananbeh

Hassan

2017

Journal of Taibah University for Science

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Genetic factors have a strong influence on obesity and are associated with body mass index (BMI). No study has investigated the relationships between glucose, the fat mass and obesity-associated (FTO) gene, obesity (BMI), and other metabolic-related traits in Saudi Arabia. This study was conducted to identify the association between glucose, BMI and the FTO rs9939609 variant with different metabolic traits among 186 female preparatory students at Taibah University in 2015. The subjects were divided into two categories based on glucose level and BMI. The results showed that 1/10th of the students were non-obese, while approximately 1/3rd had a high glucose level (HGL). The HGL group had higher mean levels of glucose, cholesterol, triglycerides, HDL, LDL, VLDL, and malondialdehyde compared to those of the normal glucose level (NGL) group. A highly positive correlation between glucose and some biochemical parameters was found in the HGL group (P < 0.05), while no correlation was found between glucose and biochemical parameters, except for the cholesterol and triglyceride levels, in the NGL group. According to the t-test, none of the biochemical parameters were significant, and no correlation existed between these parameters and glucose, except for BMI. More than 90% of the students were not aware that they had an HGL or high cholesterol level according to their response to the questionnaire distributed at the beginning of this study. These problems mainly arose from the students' diet, lack of exercise, and lifestyle. Of the 75% of students that had the T-allele, approximately 50% had the heterozygous FTO rs9939609 genotype AT. Genotypes were in Hardy-Weinberg equilibrium (P > 0.05) in the whole population (n = 186) in both obese and non-obese groups and both HGL and NGL groups. In conclusion, a positive correlation between glucose and some biochemical parameters was found in the HGL group; 24.5% of the population had the (A allele) risk factor, and 32% and 98% of the population were homozygous (AA) and heterozygous (AT) for the rs9939609 FTO obesity-risk allele that is responsible for greater energy intake. Future studies are required to study the FTO gene variant and its association with different biochemical parameters, mainly glucose, weight, and BMI, between males and females at different ages and locations in Saudi Arabia.

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“…After screening titles and abstracts, we found 2923 records to be irrelevant and excluded them. We assessed full texts of the remaining 180 articles for eligibility, of which 22 were finally included (Abd El-Aziz et al, 2011Abdel Ghany et al, 2017;Abdel-Hamed et al, 2017;Bennouar et al, 2004;Boghdady et al, 2016;Ellman et al, 2015;Elouej et al, 2016aElouej et al, , 2016bElouej et al, , 2016cEngwa et al, 2018;Fekih et al, 2014;Hooper et al, 2007;Kefi et al, 2017;Khella et al, 2017;Kodogo et al, 2016;Masemola et al, 2007;Mehri et al, 2010;Morjane et al, 2017;Sediri et al, 2011;Sellami et al, 2018) and 158 were excluded with reasons as indicated in Figure 1.…”

Section: Literature Searchmentioning

confidence: 99%

Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review

Noubiap

Mato

Guewo-Fokeng

et al. 2018

OMICS: A Journal of Integrative Biology

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Identification of genetic/genomic factors contributing to dyslipidemia is of great interest to prevention and reduction of the onset and burden of cardiovascular diseases in Africa. This systematic review summarizes available data on genetic variants associated with dyslipidemia in populations within Africa. A PubMed and EMBASE database search was conducted to identify all studies published until June 2018 on genetic susceptibility to dyslipidemia in African-based populations, excluding familial hypercholesterolemia. All studies on genetic predispositions of dyslipidemia and respecting the preestablished inclusion criteria were included in this systematic review. Because of high heterogeneity, the data were summarized narratively. Twenty-two studies investigated mostly the targeted genetic variants. A total of 51 polymorphisms in 28 susceptibility genes to dyslipidemia have been associated with a particular trait in the African populations, and through variable effects. Most polymorphisms investigated in Northern Africa seemed to have consistent effects on increasing the level of low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides in patients with diabetes, myocardial infarction, coronary artery disease, and metabolic syndrome. By contrast, only Ser447Ter and C49620T variants were associated with increased LDL-C in sub-Saharan Africa. Despite few studies available in this context in the literature, certain genetic variants were consistently associated with dyslipidemia especially in Northern Africa as highlighted in this analysis. Further data, particularly from genome-wide association studies, would help establish an African-specific reference for genetic susceptibility markers of dyslipidemia.

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Association of genetic variants in the FTO gene with metabolic syndrome: A case-control study in the Tunisian population

Cited by 18 publications

References 47 publications

Assessment of the FTO gene polymorphisms inmale patients with metabolic syndrome

Assessment of the FTO gene polymorphisms inmale patients with metabolic syndrome

Genetic, dietary, and non-dietary risk factors of obesity among preparatory-year female students at Taibah University, Saudi Arabia

Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review

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