Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study

Goulart, Alessandra Carvalho; Cheng, Suzanne; Rose, Lynda M.; Buring, Julie E.; Ridker, Paul M.; Zee, Robert Y.L.

doi:10.1016/j.ahj.2009.05.015

Cited by 19 publications

(9 citation statements)

References 44 publications

(51 reference statements)

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“…For example, hypercholesterolemia may upregulate AGTR1 expression, shown in vascular smooth muscle cells. 37 Some studies have suggested that the AGTR1 A1166C polymorphism may predict incident or prevalent metabolic syndrome, 14,38 which is consistent with our hypertension results.…”

Section: Discussionsupporting

confidence: 89%

Early Inflammatory and Metabolic Changes in Association With AGTR1 Polymorphisms in Prehypertensive Subjects

Fung

Rao

Poddar

et al. 2011

American Journal of Hypertension

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BACKGROUND The Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure in 2003 created a prehypertension category for persons with blood pressures ranging from systolic blood pressure (SBP) of 120–139 mm Hg or diastolic blood pressure (DBP) from 80 to 89 mm Hg, due to increased risk of cardiovascular disease. METHODS Our study utilized the University of California-San Diego (UCSD) Twin Hypertension Cohort. We measured comprehensive plasma cholesterol levels and metabolic (glucose, insulin, leptin) and inflammatory markers (interleukin-6 (IL-6), C-reactive protein (CRP), free fatty acids) to determine the differences between normotensive and prehypertensive subjects. Additionally, we determined whether angiotensin II receptor type-1 (AGTR1) polymorphisms, previously associated with hypertension, could predict prehypertension. RESULTS A total of 455 white subjects were included in the study (mean age 37.1 years). Prehypertensive subjects were older with greater body mass index (BMI) than the normotensives, and after adjusting for sex and age, had greater plasma glucose, insulin, and IL-6. The common AGTR1 A1166C (rs5186) polymorphism in the 3′-UTR region, particularly the presence of the 1166C allele, which fails to downregulate gene expression, predicted greater likelihood of being in the prehypertension group and higher SBP. A lesser-studied polymorphism in intron-2 of AGTR1 (A/G; rs2276736) was associated with plasma high-density lipoprotein (HDL) and apolipoprotein A-1. In a subgroup analysis of nonobese subjects (N = 405), similar associations were noted. CONCLUSION Prehypertensive subjects already exhibit early pathophysiologic changes putting them at risk of future cardiovascular disease, and AGTR1 may also contribute to this increased risk. Further investigation is needed to confirm these findings and the precise molecular mechanisms of action.

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Section: Discussionsupporting

confidence: 89%

Early Inflammatory and Metabolic Changes in Association With AGTR1 Polymorphisms in Prehypertensive Subjects

Fung

Rao

Poddar

et al. 2011

American Journal of Hypertension

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“…APOA1 gene polymorphisms (rs2727784) are well known to disturb lipid metabolism (8,26), and the current study suggests that such polymorphisms may also influence the consistency of this disturbance across eating occasions. The IL-1 pathway is an important mediator of inflammatory reactions with polymorphisms rs1800587 and rs1143634, which are implicated in the development of obesity and metabolic disarray (38)(39)(40). The current analysis also found that SNPs in genes encoding Toll-like receptor 4 (rs4986790, rs4986791) affected the reproducibility of response to an acute high fat intake.…”

Section: Discussionmentioning

confidence: 53%

Within-person variation in the postprandial lipemic response of healthy adults

Ryan¹,

Grada²,

Morris³

et al. 2013

The American Journal of Clinical Nutrition

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“…There are only few studies that prospectively investigated C5 rs17611 on outcome [8,20,21], and so far, gender aspects of C5 rs17611 have not been satisfactory investigated. Interestingly, data from The Women’s Health Genome Study showed that the C5 rs17611 SNP is associated with a decreased risk for the development of the metabolic syndrome even though male patients were not investigated [22]. To our knowledge, our study is the first that observed a gender‐related association between C5 rs17611 and the occurrence of future MACE.…”

Section: Discussionmentioning

confidence: 91%

Polymorphism of the complement 5 gene and cardiovascular outcome in patients with atherosclerosis

Hoke¹,

Speidl²,

Schillinger³

et al. 2012

Eur J Clin Investigation

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Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study

Abstract: Background-candidate genes associated with cardiovascular disease (CVD) represent potential risk factors for the metabolic syndrome (MetS).

Cited by 19 publications

References 44 publications

Early Inflammatory and Metabolic Changes in Association With AGTR1 Polymorphisms in Prehypertensive Subjects

Early Inflammatory and Metabolic Changes in Association With AGTR1 Polymorphisms in Prehypertensive Subjects

Within-person variation in the postprandial lipemic response of healthy adults

Polymorphism of the complement 5 gene and cardiovascular outcome in patients with atherosclerosis

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