Association of genetic variations in the ACLY gene with growth traits in Chinese beef cattle

Abstract

ABSTRACT. ATP citrate lyase (ACLY) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, which is a key precursor of both fatty acid and mevalonate synthesis pathways. Genetic variation of the ACLY gene may influence multiple traits associated with animal production. Here, we identified three non-synonymous mutations in ACLY exons in five beef cattle populations using DNA pool sequencing and high-resolution melting analysis. Results from association analyses revealed that the single nucleotide polymorphism (SNP) g.17127C>T is significantly associated with chest girth (P < 0.01) and body height (P < 0.05) in the Fleckvieh x Zhangye local crossbred cattle, and with body slanting length (P < 0.05) in the Simmental x Guyuan local crossbred cattle. SNP g.40427T>C is significantly associated with an increase in chest girth (P < 0.05) in the Simmental x Huzhu cattle population. These results provide preliminary evidence that polymorphisms in the bovine ACLY gene are associated with growth traits in beef cattle in northwest China. However, a larger sample set is needed to validate these findings.

Association Between ATP Citrate Lyase (ACLY) Gene Polymorphism and Fattening, Slaughter and Pork Quality Traits in Polish Pigs

“…Recently, Shang et al (2019) revealed that the ACLY gene was responsible for fatness and FA composition traits in Tibetan and Yorkshire Pigs. The ACLY gene was also associated with growth traits and fatty acid content of milk in cattle (Bouwman et al 2013;Li et al 2016). Muñoz et al (2015) detected two single nucleotide polymorphisms (SNPs) in porcine ACLY gene -c.2970T > C and c.*523 T > C. First one is a silent variant located in exon 24, however the second one is located in the 3'-UTR region.…”