Association of Genital Infections Other Than Human Papillomavirus with Pre-Invasive and Invasive Cervical Neoplasia

Ghosh, Ishita; Mandal, Ranajit; Kundu, Prabir Kumar; Biswas, Jaydip

doi:10.7860/jcdr/2016/15305.7173

Cited by 32 publications

(30 citation statements)

References 67 publications

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“…It has been described that alterations and damage to cervical epithelium produced by pathogens such as Chlamydia trachomatis , Trichomonas vaginalis and Candida spp. promote cell proliferation, tissue debridement, free radical and cytosine release and facilitate colonisation, thereby improving microorganism virulence, increasing host susceptibility, facilitating HPV entry and reducing its elimination [35]. The present study found an association between previous STI and the risk of infection by HR-HPV types.…”

Section: Discussionsupporting

confidence: 51%

The Prevalence of High-Risk HPV Types and Factors Determining Infection in Female Colombian Adolescents

et al. 2016

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This study reports six HR-HPV types’ infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12–19 year-old females using conventional generic and type-specific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01–2.71 95%CI), white ethnicity (4.40: 1.16–16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11–2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17–2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18–0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group.

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Section: Discussionsupporting

confidence: 51%

The Prevalence of High-Risk HPV Types and Factors Determining Infection in Female Colombian Adolescents

et al. 2016

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“…In addition to its effects on cervical cancer, the microbiome may impact the risk of cancer by other mechanisms as well, such as prevention of chronic infection associated with cervical neoplasia . Although the pathogenesis of endometrial cancer most commonly involves oestrogen excess, there is also a demonstrated link between pelvic inflammatory disease and endometrial cancer .…”

Section: Influence Of Vaginal Microbiome On Carcinogenesismentioning

confidence: 99%

The role of the vaginal microbiome in gynaecological cancer

Champer

et al. 2017

BJOG

145

115

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“…Согласно эпидемиологическим исследованиям, такие возбудители, как C. trachomatis, Herpes simplex, Trichomonas vaginalis, Cytomegalovirus и БВ, являются потенциальными ко-факторами ПВИ, но убедительных доказательств при-чинно-следственной связи любого из перечисленных выше патогенов с развитием CIN нет [19][20][21][22].…”

Section: впч-инфекция цервицит и рак шейки маткиunclassified

Cervicitis: an Unresolved Gynecological Problem

Bebneva¹,

Оразов²,

Kostin³

2018

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Association of Genital Infections Other Than Human Papillomavirus with Pre-Invasive and Invasive Cervical Neoplasia

Cited by 32 publications

References 67 publications

The Prevalence of High-Risk HPV Types and Factors Determining Infection in Female Colombian Adolescents

The Prevalence of High-Risk HPV Types and Factors Determining Infection in Female Colombian Adolescents

The role of the vaginal microbiome in gynaecological cancer

Cervicitis: an Unresolved Gynecological Problem

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