Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study

Heshmat, Ramin; Shafiee, Gita; Qorbani, Mostafa; Azizi-Soleiman, Fatemeh; Djalalinia, Shirin; Motlagh, Mohammad Esmaeil; Ardalan, Gelayol; Ahadi, Zeinab; Safari, Omid; Safiri, Saeid; Kelishadi, Roya

doi:10.15171/jcvtr.2016.23

Cited by 16 publications

(8 citation statements)

References 31 publications

(34 reference statements)

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“…This is in agreement with the results of previously published studies, proving a compensatory decrease in ghrelin when adipose tissue increases [14,24]. However, some previous studies in children found no correlation between ghrelin and obesity-related hypertension, a correlation that was recently shown in adults [15,25]. In addition, our finding of the role of ghrelin in normal weight hypertension has not been found in any previous studies in children.…”

Section: Discussionsupporting

confidence: 93%

“…Therefore, we confirmed previous research proving its role in obesity [26,27]. All the analyzed groups had a statistically significant positive correlation between leptin and BMI and a negative correlation between ghrelin and adiponectin and BMI, which are in accordance with earlier studies, thus confirming their potential for the determination of the obesity risk [8,15,26].…”

Section: Discussionsupporting

confidence: 92%

“…In a few studies published on ghrelin, lower values have been revealed in obese children [10,14]. In addition, its association with some cardio-metabolic factors has been shown [15].…”

Section: Introductionmentioning

confidence: 99%

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The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents

2020

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Introduction: The occurrence of cardiovascular diseases and metabolic disorders steadily increases with the body mass index (BMI). Since the latter is not the best and earliest indicator of obesity and cardiovascular risk, the aim of the study was to evaluate some potential biological markers that would allow us to detect children and adolescents at higher risk at an early stage. Methods: A sample of 330 children and adolescents were included in the study and divided into four groups: obese patients with hypertension, normal-weight patients with hypertension, patients with mildly elevated lipids and a control group of healthy children and adolescents. Some clinical parameters (age, body weight, body height, BMI, waist circumference, hip circumference, blood pressure), biochemical parameters (glucose, total cholesterol, triglycerides, HDL, LDL, apolipoprotein A1, homocysteine) and biological markers of obesity (ghrelin, adiponectin, leptin) were evaluated. Results: Ghrelin and adiponectin were found to have a strong negative statistically significant correlation with BMI in all three observed groups (p < 0.001), but not in the control group (p = 0.053 and p = 0.316, respectively). In addition, leptin had a strong positive statistically significant correlation with BMI in all four groups (p < 0.001 for the research groups, p = 0.009 for the controls). In the group of obese patients with hypertension, statistically significant differences in all three markers of obesity were found in comparison to the control group (p < 0.001 for all markers). In the group of patients with mildly elevated lipids, ghrelin and leptin were significantly different (p = 0.002 and p < 0.001, respectively). In the group of normal-weight hypertensive patients, only values of ghrelin were different compared to the control group (p = 0.001). Conclusion: In the research groups, significant differences were found in clinical, biochemical and biological parameters compared to the control group. The observed biological markers of obesity are useful early markers for identifying groups of patients that are at cardiovascular risk.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

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The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents

2020

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“…2016, 45 and partially in agreement with the results of a study conducted by Stepien et al, in Poland, which revealed a non-significant positive correlation with WHR in insulin-sensitive obese patients. However, in the insulin-resistant group of Stepien's study, ghrelin was not significantly correlated negatively with WHR.…”

Section: Discussionsupporting

confidence: 91%

The Association Between Salivary Ghrelin Levels with Anthropometric Measures in Underweight, Normal, Overweight and Obese Healthy Adult Males

Abdalla

Choo

2020

European Endocrinology

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“…It is associated with a 2-fold increase in risk of cardiovascular disease (CVD), CVD mortality, and stroke, and a 1.5-fold increase in risk of all-cause mortality [ 7 – 9 ]. The prevalence of metabolic syndrome is increasing worldwide because of underlying increase in prevalence of obesity; the Third National Health and Nutrition Examination Survey (NHANES III) reported an alarming unadjusted and age-adjusted prevalence of the metabolic syndrome of 21.8% and 23.7%, respectively [ 10 , 11 ]. In Iran according to the results of Tehran Lipid and Glucose Study (TLGS), 33.7% of adults aged ≥20 years old were suffering from metabolic syndrome [ 12 ].…”

Section: Backgroundsmentioning

confidence: 99%

Dietary diversity score is associated with cardiovascular risk factors and serum adiponectin concentrations in patients with metabolic syndrome

Farhangi

Jahangiry

2018

BMC Cardiovasc Disord

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BackgroundMetabolic syndrome is associated with cardio-metabolic risk factors and lipid abnormalities. Previous studies evaluated the dietary habits and nutrient intakes among patients with metabolic syndrome; however the association between metabolic risk factors and adiponectin with dietary diversity score (DDS) in patients with metabolic syndrome has not been evaluated yet. Therefore the aim of the current study was to evaluate these relationships among patients with metabolic syndrome.MethodsOne hundred sixty patients with metabolic syndrome were recruited in the study. The anthropometric parameters including weight, height, waist circumference and hip circumference were measured. Serum adiponectin concentration was measured by enzyme- linked immunosorbent assay method (ELISA). Lipid profile and fasting serum glucose concentrations (FSG) were also measured with enzymatic colorimetric methods. Blood pressure was also measured and DDS was calculated using the data obtained from food frequency questionnaire (FFQ).ResultsSubjects in lower DDS categorizes had significantly lower energy and fiber intake; whereas mean protein intake of subjects in the highest quartile was significantly higher than second quartile. Higher prevalence of obesity was also observed in the top quartiles (P < 0.001). Subjects in the lower quartiles had higher serum triglyceride concentrations and systolic blood pressure (SBP) values and lower serum adiponectin concentrations compared with subjects in higher DDS categorizes (P < 0.05). The prevalence of metabolic syndrome components among patients in lower DDS quartiles was significantly higher (P < 0.05).ConclusionOur study found a lower serum triglyceride and SBP and higher serum adiponectin concentrations in top quartiles of DDS. The findings clarify the possible preventive role of higher dietary diversity score against metabolic syndrome. However, for further confirming the findings, more studies are warranted.

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Association of ghrelin with cardiometabolic risk factors in Iranian adolescents: the CASPIAN-III study

Cited by 16 publications

References 31 publications

The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents

The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents

The Association Between Salivary Ghrelin Levels with Anthropometric Measures in Underweight, Normal, Overweight and Obese Healthy Adult Males

Dietary diversity score is associated with cardiovascular risk factors and serum adiponectin concentrations in patients with metabolic syndrome

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