Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum

Darwin, L.; Deole, Nishigandh; Kandala, N-B; Smith, S. C.; Grammatopoulos, Dimitris K.

doi:10.1016/j.jpsychires.2013.05.003

Cited by 65 publications

(51 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, CRHR1 deficiency leads to impaired stress response [40,41]. CRHR1 polymorphisms have been previously associated with depressive disorders [26,42,43] and with suicidal and aggressive behaviours, symptoms frequently observed in subjects with BPD [44,45]. Our results may support the hypothesis of the involvement of CRHR1 on BPD.…”

Section: Discussionsupporting

confidence: 85%

The role of hypothalamus–pituitary–adrenal genes and childhood trauma in borderline personality disorder

Martín-Blanco

Ferrer

Soler

et al. 2015

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Current knowledge suggests that borderline personality disorder (BPD) results from the interaction between genetic and environmental factors. Research has mainly focused on monoaminergic genetic variants and their modulation by traumatic events, especially those occurring during childhood. However, to the best of our knowledge, there are no studies on the genetics of hypothalamus-pituitary-adrenal (HPA) axis, despite its vulnerability to early stress and its involvement in BPD pathogenesis. The aim of this study was to investigate the contribution of genetic variants in the HPA axis and to explore the modulating effect of childhood trauma in a large sample of BPD patients and controls. DNA was obtained from a sample of 481 subjects with BPD and 442 controls. Case-control differences in allelic frequencies of 47 polymorphisms in 10 HPA axis genes were analysed. Modulation of genetic associations by the presence of childhood trauma was also investigated by dividing the sample into three groups: BPD with trauma, BPD without trauma and controls. Two FKBP5 polymorphisms (rs4713902-C and rs9470079-A) showed significant associations with BPD. There were also associations between BPD and haplotype combinations of the genes FKBP5 and CRHR1. Two FKBP5 alleles (rs3798347-T and rs10947563-A) were more frequent in BPD subjects with history of physical abuse and emotional neglect and two CRHR2 variants (rs4722999-C and rs12701020-C) in BPD subjects with sexual and physical abuse. Our findings suggest a contribution of HPA axis genetic variants to BPD pathogenesis and reinforce the hypothesis of the modulating effect of childhood trauma in the development of this disorder.

show abstract

Section: Discussionsupporting

confidence: 85%

The role of hypothalamus–pituitary–adrenal genes and childhood trauma in borderline personality disorder

Martín-Blanco

Ferrer

Soler

et al. 2015

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…1 Some women with PND may be genetically more reactive to the environmental trigger for depression. 19 In other women, who have a general vulnerability to depression, PND may occur because childbirth is a stressor. 1 The strongest predictors of PND are antenatal anxiety and antenatal depression, 14 lack of social support, a history of depression, neuroticism, low self-esteem, stressful life events during pregnancy, poor marital relationship and domestic violence.…”

Section: Prevalencementioning

confidence: 99%

A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression

Morrell

Sutcliffe

Booth

et al. 2016

Health Technol Assess

101

105

View full text Add to dashboard Cite

A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression C Jane Morrell, 1 * Paul Sutcliffe, 2 Andrew Booth, 3 John Stevens, 3 This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: http://www.nets.nihr.ac.uk/programmes/hta This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 11/95/03. The contractual start date was in November 2012. The draft report began editorial review in August 2014 and was accepted for publication in June 2015. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department ...

show abstract

“…Positive associations with depression during pregnancy were found with minor alleles of a haplotype composed of four FADS1/ FADS2 single nucleotide polymorphisms (SNPS) (Xie and Innis, 2009), low activity variants of COMT (Doornbos et al, 2009) and MAOA (Doornbos et al, 2009), haplotype blocks in the promoter region of TPH2 that are known to be functionally significant , OXT genotype, but not OXTR genotype , the BclI GR SNP and the CRHR1 SNP (rs242939) (Engineer et al, 2013).…”

Section: Depression During Pregnancymentioning

confidence: 99%

The Influence of genetic factors on peripartum depression: A systematic review

Figueiredo

Parada

Araújo

et al. 2015

Journal of Affective Disorders

View full text Add to dashboard Cite

Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum

Cited by 65 publications

References 46 publications

The role of hypothalamus–pituitary–adrenal genes and childhood trauma in borderline personality disorder

The role of hypothalamus–pituitary–adrenal genes and childhood trauma in borderline personality disorder

A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression

The Influence of genetic factors on peripartum depression: A systematic review

Contact Info

Product

Resources

About