Association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer

Xu, Feng; Zheng, Bo; Shi, Jun-Jie; Qian, Jun; He, Wei; Zhou, Hua-Fu

doi:10.1007/s11033-012-1908-1

Cited by 12 publications

(14 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results indicated that GSTP1 polymorphism was not significantly associated with prostate cancer 30, esophageal cancer 32, head and neck cancer 33, lung cancer 34, ovarian cancer 36 and thyroid cancer 37; this polymorphism might contribute to the development of gastric cancer 31 or breast cancer 35 in East Asians, but not in other ethnic populations. However, besides our study, these meta-analyses did not consider the effect of gene-gene and gene-environment interactions in the development of cancer.…”

Section: Discussionmentioning

confidence: 87%

“…Recently, many meta-analyses have been performed to investigate the association between GSTP1 Ile105Val polymorphism and many types of cancer risk (e.g., prostate cancer 30, gastric cancer 31, esophageal cancer 32, head and neck cancer 33, lung cancer 34, breast cancer 35, ovarian cancer 36 and thyroid cancer 37). The results indicated that GSTP1 polymorphism was not significantly associated with prostate cancer 30, esophageal cancer 32, head and neck cancer 33, lung cancer 34, ovarian cancer 36 and thyroid cancer 37; this polymorphism might contribute to the development of gastric cancer 31 or breast cancer 35 in East Asians, but not in other ethnic populations.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Glutathione S-transferase P1 Ile105Val Polymorphism and Oral Cancer Risk: A Meta-Analysis

Li¹,

Chen²,

Liu³

2013

Int. J. Med. Sci.

View full text Add to dashboard Cite

Objective The glutathione S-transferase P1 (GSTP1) gene has been suggested to play an important role in the pathogenesis of oral cancer. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of GSTP1 Ile105Val polymorphisms with oral cancer risk.Methods Published literature from PubMed and EMBASE were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model.Results 13 studies (1803 oral cancer cases and 2998 controls) for GSTP1 Ile105Val polymorphism were included in the meta-analysis. The results indicated that there was no significant association between GSTP1 Ile105Val polymorphism and oral cancer in the overall population (OR=1.30, 95%CI=0.92-1.38, I2=48.0%, p for heterogeneity=0.027). Further subgroup analysis by ethnicity suggested that GSTP1 Ile105Val polymorphism was significantly associated with oral cancer only in East Asians (OR=1.64, 95%CI=1.16-2.31, I2=0.0%, p for heterogeneity=0.525), but not in Caucasians (OR=1.16, 95%CI=0.73-1.82, I2=7.5%, p for heterogeneity=0.299), Africans (OR=1.10, 95%CI=0.37-3.28), South Asians (OR=1.20, 95%CI=0.69-2.08, I2=74.3%, p for heterogeneity=0.021) and mixed population (OR=0.91, 95%CI=0.70-1.20, I2=39.7%, p for heterogeneity=0.174).Conclusions The present meta-analysis has limited evidence to support the association of GSTP1 Ile105Val polymorphism with HCC risk in the overall population. However, GSTP1 Ile105Val polymorphism might be associated with risk of oral cancer in East Asians.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase P1 Ile105Val Polymorphism and Oral Cancer Risk: A Meta-Analysis

Li¹,

Chen²,

Liu³

2013

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Zhou et al found that smoking could modify the effects of X-ray cross-complementing group 1 and excision repair cross-complementing group 2 polymorphisms on the risk for lung cancer, indicating a gene–environmental interaction in the lung carcinogenesis [36]. It has been well-established that there is a range of genetic susceptibility to lung cancer risk, such as microsomal epoxide hydrolase 1, matrix metalloproteinase-1, and glutathione S -transferase P1 [37–39]. In addition, the polymorphism of p53 codon 72 Arg/Pro also has been demonstrated to modify the risk for lung cancer among Asians in many previous case–control studies [21–34].…”

Section: Discussionmentioning

confidence: 99%

P53 codon 72 Arg/Pro polymorphism and lung cancer risk in Asians: an updated meta-analysis

Wang¹,

Xin-gang

Tan

et al. 2013

Tumor Biol.

View full text Add to dashboard Cite

The polymorphism of p53 codon 72, a transversion of G to C (Arg to Pro), has been demonstrated to be associated with the risk for lung cancer. However, individual studies conducted in Asians have provided conflicting and inconclusive findings. Thus, we performed a meta-analysis by pooling all currently available case–control studies to estimate the effect of p53 codon 72 Arg/Pro polymorphism on the development of lung cancer. The pooled odds ratios (ORs) with the corresponding 95 % confidence intervals (95 %CIs) were calculated to assess this effect. A total of 14 individual studies involving 7,929 cases and 5,924 controls were included into this meta-analysis according to the inclusion criteria. The overall OR for the dominant genetic model indicated that the p53 codon 72 Arg/Pro variant was positively correlated with lung cancer risk (ORArg/Pro + Pro/Pro vs. Arg/Arg = 1.14, 95 %CI 1.07–1.23, POR < 0.001). Similar results were found in the stratified analysis of population-based studies. The histological types of lung cancer and smoking status seemed to exert no effect on the lung cancer risk. Sensitivity analysis confirmed the stability of the above findings. The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is a risk factor for lung cancer in the Asian population. However, the potential role of gene–environment interaction in lung cancer susceptibility needs further investigation in future studies with high quality.

show abstract

“…Gao et al [ 18 ] on the combined effects of GSTM1 present/null and GSTT1 present/null polymorphisms with LC risk will be considered as “positive” result in the overall population, Ye et al [ 15 ] on the GSTM1 null genotype with LC risk in all races, Liu et al [ 41 ] on the GSTM1 null genotype with LC risk in Chinese populations, and Xu et al [ 33 ] on the GSTP1 IIe105Val polymorphism with LC risk will be considered as “positive” results because their studies represent the most credible findings. Li et al, [ 28 ] Sengupta et al, [ 50 ] Yang et al, [ 19 ] Yang et al, [ 34 ] Wang et al, [ 40 ] and Feng et al [ 21 ] will be classified as less-credible results (higher heterogeneity, lower statistical power, FPRP > 0.2 and BFDP > 0.8).…”

Section: Resultsmentioning

confidence: 99%

Individual and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on lung cancer risk

Zhang

Yang

et al. 2021

Medicine

View full text Add to dashboard Cite

Thirty-five previous meta-analyses have been reported on the individual glutathione S-transferase M1 ( GSTM1 ) present/null, glutathione S-transferase T1 ( GSTT1 ) present/null, and glutathione S-transferase P1 ( GSTP1 ) IIe105Val polymorphisms with lung cancer (LC) risk. However, they did not appraise the credibility and explore the combined effects between the 3 genes and LC risk. We performed a meta-analysis and re-analysis of systematic previous meta-analyses to solve the above problems. Meta-analyses of Observational Studies in Epidemiology guidelines were used. Moreover, we employed false-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and the Venice criteria to verify the credibility of current and previous meta-analyses. Significantly increased LC risk was considered as “highly credible” or “positive” for GSTM1 null genotype in Japanese (odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.17–1.44, I 2 = 0.0%, statistical power = 0.997, FPRP = 0.008, BFDP = 0.037, and Venice criteria: AAB), for GSTT1 null genotype in Asians (OR = 1.23, 95% CI = 1.12–1.36, I 2 = 49.1%, statistical power = 1.000, FPRP = 0.051, BFDP = 0.771, and Venice criteria: ABB), especially Chinese populations (OR = 1.31, 95% CI = 1.16–1.49, I 2 = 48.9%, Statistical power = 0.980, FPRP = 0.039, BFDP = 0.673, and Venice criteria: ABB), and for GSTP1 IIe105Val polymorphism in Asians (Val vs IIe: OR = 1.28, 95% CI = 1.17–1.42, I 2 = 30.3%, statistical power = 0.999, FPRP = 0.003, BFDP = 0.183, and Venice criteria: ABB). Significantly increased lung adenocarcinoma (AC) risk was also considered as “highly credible” or “positive” in Asians for the GSTM1 (OR = 1.35, 95% CI = 1.22–1.48, I 2 = 25.5%, statistical power = 0.988, FPRP < 0.001, BFDP < 0.001, and Venice criteria: ABB) and GSTT1 (OR = 1.36, 95% CI = 1.17–1.58, I 2 = 30.2%, statistical power = 0.900, FPRP = 0.061, BFDP = 0.727, and Venice criteria: ABB) null genotype. This study indicates that GSTM1 null genotype is associated with increased LC risk in Japanese and lung AC risk in Asians; GSTT1 null genotype is associated with increased LC risk in Chinese, and GSTP1 IIe105Val polymorphism is associated with increased LC risk in Asians.

show abstract

Association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer

Cited by 12 publications

References 66 publications

Glutathione S-transferase P1 Ile105Val Polymorphism and Oral Cancer Risk: A Meta-Analysis

Glutathione S-transferase P1 Ile105Val Polymorphism and Oral Cancer Risk: A Meta-Analysis

P53 codon 72 Arg/Pro polymorphism and lung cancer risk in Asians: an updated meta-analysis

Individual and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on lung cancer risk

Contact Info

Product

Resources

About