Association of GSTP1 −313A/G polymorphisms and endometriosis risk: a meta-analysis of case–control studies

Chen, Xu; Yan, Ye; Li, Ping; Yang, Zheng; Qin, Lingyan; Mo, Wuning

doi:10.1016/j.ejogrb.2013.10.005

Cited by 22 publications

(19 citation statements)

References 32 publications

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“…Nonetheless, several other studies have found contradictory results in the form of no association between GSTP1-313 A > G and endometriosis risk in some other populations like that done among Chinese [15], Japanese [16], Italian [17], Indian [20] and Korean [22] subjects. A recent meta-analysis study showed that GSTP1-313 A > G polymorphism was not associated with endometriosis risk in the overall population (A vs. G: OR = 1.02, P = 0.511) [24]. These contradictory results might be attributed to different ethnic origins, environmental difference in addition to problems related to research methodologies like the adequacy of sample size and proper diagnostic methods.…”

Section: Discussionmentioning

confidence: 99%

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Association of glutathione-S-transferase P1 (GSTP1)-313 A>G gene polymorphism and susceptibility to endometrial hyperplasia among Egyptian women

Elsaid

Al-Kholy

Ramadan

et al. 2015

Egyptian Journal of Medical Human Genetics

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Background: Endometrial hyperplasia (EH) occurs when the endometrium, the lining of the uterus, becomes too thick, causing abnormal uterine bleeding. In some cases, it can lead to endometrial carcinoma if untreated. Glutathione-S-transferases (GSTs) enzymes have a role in the metabolism of a lot of disease-causing carcinogens and mutagens that are present in environments of human. GSTP1-313 A > G gene polymorphism was associated with significantly high risk of endometrial carcinoma in some reports. The aim of this work is to assess the association of this polymorphism with the susceptibility of EH among a sample of Egyptian women.Subjects and methods: This study included 84 unrelated EH Egyptian women who were compared to 134 healthy controls from the same locality. For all subjects, DNA was genotyped for GSTP1-313 A > G (Ile105Val) polymorphism using the PCR-RFLP technique.Results: The frequency of GSTP1-313 AG and GG genotypes was noted to be significantly higher among most of the cases with EH compared to controls (79.8% vs. 42.0%, OR = 8.63, 95% CI = 4.53-16.46, p < 0.001). Also the frequency of the GSTP1-313 G allele was significantly higher among most of the cases compared to controls (24.9% vs. 16.8%, OR = 3.72, 95% CI = 2.39-5.79, p < 0.001). Furthermore, there was a significant increase of endometrial thickness in the EH women compared to controls (p < 0.001).Conclusions: GSTP1-313 G allele carriage was associated with susceptibility of EH among a sample of Egyptian women.

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Section: Discussionmentioning

confidence: 99%

“…The GST gene is one of the important genes which has a role in regulate immune, metabolism, endocrine and are closely related to the susceptibility with endometrial carcinoma [24]. GSTP1 is the most important member of GST family which contributes to the detoxification of electrophilic compounds by glutathione conjugation [11].…”

Section: Discussionmentioning

confidence: 99%

Association of glutathione-S-transferase P1 (GSTP1)-313 A>G gene polymorphism and susceptibility to endometrial hyperplasia among Egyptian women

Elsaid

Al-Kholy

Ramadan

et al. 2015

Egyptian Journal of Medical Human Genetics

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“…We consider sample size as an important factor contributing to the above discrepancy. Small-study bias is not an emerging event when performing genetic association studies [26]. The current result of IL-10 -819 loci polymorphism may be attributed to race.…”

Section: Discussionmentioning

confidence: 94%

Association between the IL-10 and IL-6 polymorphisms and brucellosis susceptibility: a meta-analysis

Jin

Yin

et al. 2020

BMC Med Genet

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Background: Brucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products. IL-10 (− 1082 G/A, − 819 C/T, − 592C/A) and IL-6-174 G/C polymorphisms have a great relationship with IL-10 and IL-6 production, which brings about Brucellosis pathogenesis and development. So far, the results of published literatures were controversial. Now, we perform a meta-analysis in different ethnic populations to get a more precise estimate of above polymorphisms with Brucellosis susceptibility. Methods: Both OR and corresponding 95%CI were enrolled to make an assessment of the association strength through extracting genotyping frequency of cases and controls. The χ2-test based Q-statistic and I 2 statistics were applied. If there was no evident heterogeneity, the fixed-effects model would be applied. If not, the random-effects model would be used. Results: The significant associations were only found in Asian population of − 819 loci under three genetic models as follows: (Allele model: OR = 0.60, 95%CI = 0.44-0.82, P = 0.001), (homozygote comparison: OR = 0.24, 95%CI = 0.09-0.62, P = 0.003), (recessive genetic model: OR = 0.22, 95%CI = 0.05-0.91, P = 0.036). Conclusion: In conclusion, IL-10 − 819 loci polymorphism contributes no risk to Caucasian population but may be associated with decreased risk in Asian population. And IL-10-1082 G/A, 592 loci and IL-6-174 G/C polymorphism are not associated with Brucellosis risk.

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“…Two meta-analysis evaluated the glutathione S-transferase variations in endometriosis women ( 13 , 34 ). Guo et al performed a meta-analysis involving 14 studies investigating GSTM1 and nine GSTT1 studies.…”

Section: Discussionmentioning

confidence: 99%

“…However, there was evidence of publication bias in this meta- analysis, indicating that the size of the increased risk associated with the GSTT1 deletion variant may actually be smaller or non- existent ( 9 ). In a recent meta- analysis by Chen et al they concluded that the GSTP1 313 A/G may not be associated with endometriosis risk ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population

Hassani¹,

Saliminejad²,

Heidarizadeh³

et al. 2016

IJRM

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Background:Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent. Objective:We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population. Materials and Methods: In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods. Results:The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%).Conclusion:Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women.

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Association of GSTP1 −313A/G polymorphisms and endometriosis risk: a meta-analysis of case–control studies

Cited by 22 publications

References 32 publications

Association of glutathione-S-transferase P1 (GSTP1)-313 A>G gene polymorphism and susceptibility to endometrial hyperplasia among Egyptian women

Association of glutathione-S-transferase P1 (GSTP1)-313 A>G gene polymorphism and susceptibility to endometrial hyperplasia among Egyptian women

Association between the IL-10 and IL-6 polymorphisms and brucellosis susceptibility: a meta-analysis

Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population

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