Association of Helicobacter Pylori Infection and Stomach Cancer

Abstract

Introduction: Helicobacter pylori (H. Pylori) as a primary etiological factor in carcinoma stomach. Associationof H. Pylori in gastric cancer has been documented to be in more than 50% of cases. In underdevelopedcountries, this association is shown to be much higher according to different studies.Methods: A prospective observational study of 40 consecutive cases of carcinoma stomach was under takenin surgical department of Shree Birendra hospital and Bir hospital, for a period of two years 2009 to 2011.Location and pathological types of the lesion were noted and all specimens were investigated to see presenceof helicobacter pylori by rapid urease test (RUT) and histological examination.Results: Out of 40 patients, helicobacter pylori positivity was seen in 27 (67.5%) cases by both rapid ureasetest and Histopathological examination (HPE). Regarding the pathological types, out of 26 intestinal type of castomach, 20 (76.92%) cases were positive for H. pylori infection, whereas out of 14 diffuse type of ca stomach,7(50%) cases were positive for H. pylori. In 29 cases of distal ca stomach, H. pylori positivity was seen in 22(75.86%) cases, whereas in rest of the 11 cases the lesion involved other part of the stomach, H. pylori positivitywas seen in 5(45.45%) cases.Conclusion: Helicobacter pylori infection is higher in prevalence in cases of stomach cancer. Its associationwith intestinal histological type of stomach cancer is more common than diffuse type. There is higher prevalenceof Helicobacter pylori infection in distal carcinoma. doi: http://dx.doi.org/10.3126/mjsbh.v12i2.12927

Association of Helicobacter Pylori in Carcinoma Stomach at Maharaja Krishna Chandra Gajapat Medical College: A Prospective Study

“…As per this study, 62 (58.49%) out of 106 cases were found to be positive for H. pylori by RUT and 72 (67.92%) cases were positive for H. pylori on smear with staining. This is similar to the findings of Thapa et al [17] who found RUT positivity in 67.5% cases.…”

“…H. pylori positivity rate in tumor tissue of intestinal-type carcinomas was higher than that of diffuse carcinomas. Irrespective of the histological type of lesion, 67.92% of gastric carcinoma are associated with H. pylori similar to the findings of 69% in Thapa et al [17]. This is at par with the finding of 74% of Buruk et al [19].…”

Application of PCR and Microscopy to Detect Helicobacter pylori in Gastric Biopsy Specimen among Acid Peptic Disorders at Tertiary Care Centre in Eastern Nepal

“…The results were undoubtedly higher than our findings which could be due to variation in staining techniques and sampling population. Moreover, the study conducted in Nepalese population showed that 67.5% of stomach carcinoma cases were found H. pylori positivity by histopathology and rapid urease analysis [11]. The contrasting results in the aforementioned study could be differences in study population enrolled and the application of diagnostic methods such as histopathological examination using hematoxylin and eosin.…”

“…It is utmost important to identify H. pylori infection in gastroduodenal diseases so that the probable gastrointestinal malignancy can be prevented on time. In developing countries such as Nepal, the prevalence of H. pylori is notably higher in number of duodenal ulcer, gastric ulcer, and gastritis but a few data on burden of infections are available [11]. Therefore, this study has the aim to detect H. pylori in upper gastrointestinal endoscopic biopsy specimens by different diagnostic tools and evaluate the accuracy of H. pylori detecting tools in acid peptic disorder patients attending B. P. Koirala Institute of Health Sciences, Dharan.…”

Clinicopathological Study of Helicobactor Pylori Infection and Gastric Carcinoma at a Tertiary Care Hospital in Kathmandu

“…4 The human immune system identifies H. pylori as a foreign particle and provokes the inflammatory response to eradicate the bacterium from the body which induces the serious infection and may further progress to cancer. 5 The chronic infection with H. pylori bacteria is the most important risk factor for the development of non-cardia gastric cancer and lower grade B-cell mucosa associated lymphoid tissue (MALT) lymphoma estimating 6,60,000 cancer cases in the year 2008 attributed to H. pylori and corresponding to 5.2% of the total burden from all cancers globally. 6 In Nepal, the prevalence of H. pylori was found to be lesser than that observed in other studies conducted in developing Asian countries, but the bacterium was remarkably seen in maximum number of duodenal ulcer, gastric ulcer and gastritis and the gastric cancer was significantly associated with H. pylori infection.…”