Association of Helicobacter Pylori Infection and Diabetes Mellitus Type 2 Subjects in Yaounde Cameroon Using a Panel of Serum Biomarkers (PGII, HpIgG): A Case Control Study

Ebule, IA; Djune, Fak; Njeambosay, BA; Doh, GN; Metaghue, G; Majuikouo, L; Befolo, Mhdm; Nkayo, M; Tanni, B; Heugueu, C; Feuatsapk, C; Noah, ND; Paloheimo, Lea; Syrjänen, K

doi:10.23937/2469-584x/1510053

Cited by 6 publications

(11 citation statements)

References 2 publications

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“…In another study done in Africa reported that 88% diabetic and 67% non-diabetic patients were found to have a positive status for anti-H. pylori antibodies. 17 Similar results were observed in a study by Jeon et al as well as Huang et al 18,19 On the other hand, some studies have found contradictory results. In diabetic group vs the non-diabetic group, H. pylori positive patients were 28.1% vs 29.6% in one study and 50.8% vs 56.4% in another study.…”

Section: Discussionsupporting

confidence: 78%

Helicobacter pylori infection among type 2 diabetics: a case control study

et al. 2020

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Background: Helicobacter pylori infection has been associated with hyperglycemia among type 2 diabetics. The objective of this study was to compare the H. pylori infection frequency in diabetic and non-diabetic patients.Methods: This case-control study was done at Al-Tibri Medical College and Hospital from May 2019 to August 2019. After written and informed consent, patients between 18-75 years with epigastric burning, dyspepsia, regurgitation were included and with history of eradication therapy, antibiotic or NSAID use in the last 6 months or surgery of upper GI tract months were excluded. Type 2 diabetics were placed in one group and non-diabetic individuals in another. Both groups were compared for presence of H. pylori infection. Data was analysed using SPSS. Demographic variables included age, gender and status of H. pylori infection. Quantitative data was expressed as frequency and percentages. Chi-square test was applied to test for significance keeping p-value of <0.05 statistically significant.Results: From 480 patients, 355 patients showed positive H. pylori, among them 282 were diabetic and 73 non-diabetic (p-value <0.001). Amongst the 355 diabetics, 55% were male Among 73 non-diabetics, 64% were male. All the patients in the study had dyspeptic symptoms and complained of dyspepsia, epigastric burning and regurgitation.Conclusions: A substantial relationship between H. pylori infection among type 2 diabetes mellitus patients was observed compared to non-diabetics. As a result, diabetic patients having active dyspeptic symptoms should undergo further confirmatory tests for diagnosing H. pylori infection.

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Section: Discussionsupporting

confidence: 78%

Helicobacter pylori infection among type 2 diabetics: a case control study

et al. 2020

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“…This is consistent with the previously reported studies. [ 4 5 6 7 8 9 10 16 17 18 19 20 21 ] Most recently, a meta-analysis suggested a trend toward more frequent H. pylori infections in T2DM patients. [ 3 ] Meanwhile, the impact of H. pylori and T2DM was explored in Bener et al .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection among type 2 diabetes mellitus

et al. 2020

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Background: Several conducted studies have reported a higher and more frequent Helicobacter pylori infection rate in type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the prevalence and its association between H. pylori infection and T2DM. Materials and Methods: A case and control study was conducted based on 529 T2DM patients and 529 control. H. pylori was assessed by Serum anti- H. pylori immunoglobulin G (IgG) and IgA. Furthermore, patients were investigated for fasting blood glucose (FBG) levels, glycosylated hemoglobin (HbA1c), serum cholesterol, and other biochemistry parameters. Results: The findings showed a positive significantly higher antibody titer for H. pylori infection (IgA > 250) in diabetic patients (50.7%) compared to controls (38.2%) ( P < 0.001). Similarly, H. pylori infection for IgG > 300 titer was higher in T2DM patients (73.5%) compared to controls 61.8%) ( P < 0.001). Further, the mean values were statistically significant diabetes with H. pylori infection for IgG > 300 titer and IgA > 250 titer, regarding Vitamin D, HbA1C ( P < 0.001), FBG, calcium, creatinine, total cholesterol, LHDL, triglyceride levels, uric acid, bilirubin, thyroid-stimulating hormone (TSH), and systolic and diastolic blood pressure. The diabetic patients showed higher prevalence rate of symptoms than controls included: hypertension (14.3%), vomiting (15.5%), muscular symptoms (35.2%), bloating/distension (13.2%), abdominal pain (17%), nausea (9.6%), anemia (17%), kidneys (20.8%), chronic bronchitis (14.7%), gastrointestinal (23.8%), and diarrhea (20.4%). Conclusions: The current study revealed that H. pylori infections were significantly higher in diabetic patients compared to controls. Furthermore, T2DM patients infected with H. pylori positive reported a higher prevalence rate of symptoms than H. pylori negative .

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“…A wide range of studies has demonstrated that patients with DM are at a greater risk of HP infection [12][13][14][15][16], however the results certainly depend on the country where the research has been carried out and epidemiological situation with HP in the region. Some researchers have proved that HP infection is highly associated with T2DM, however its prevalence widely vary from 59% to 75% [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of HP infection among patients with DM is debatable. However, some studies suggest the link between HP infection and T2DM, claiming that prevalence of HP among patients with T2DM is much higher than in non-diabetics [12][13][14] and patients with T1DM [15]. The group of Chinese researchers found opposite relationship: people with positive HP status are under the risk of DM [16].…”

Section: Introductionmentioning

confidence: 99%

Do H. Pylori Status and Small Intestinal Bacterial Overgrowth Determine the Clinical Course of Chronic Active Gastritis in Patients With Type 2 Diabetes Mellitus?

2020

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The aim: To define clinical peculiarities of chronic active gastritis in patients with type 2 diabetes mellitus (T2DM) considering Helicobacter pylori (HP) status and small intestinal bacterial overgrowth (SIBO). Materials and methods: 172 patients with chronic active gastritis were enrolled in the study, 92 out of them had concomitant T2DM. Symptoms were collected with the questionnaire, HP infection was diagnosed with stool antigen test, SIBO was assessed with glucose hydrogen breath test. Results: 87.5% (n=70) patients with chronic gastritis without DM had epigastric pain, however those with T2DM reported pain only in 41.3% (n=38) cases. Other symptoms included: nausea, bloating, early satiety, postprandial fullness, heartburn, belching and vomiting. HP infection in patients with chronic gastritis and concomitant T2DM is significantly associated with symptoms of epigastric pain (OR=2.78, 95%CI 0.92-8.41), bloating (OR=3.92, 95%CI 1.40-10.99), nausea (OR=2.32, 95%CI 0.85-0.6.30), postprandial fullness (OR=1.45, 95%CI 0.54-3.87) and belching (OR=1.01, 95%CI 0.32-3.16), whereas SIBO – with bloating (OR=8.82, 95%CI 2.88-27.01), nausea (OR=5.15, 95%CI 1.88-14.10) and belching (OR=2.53, 95%CI 0.67-9.52). Conclusions: Patients with T2DM and chronic active gastritis report epigastric pain significantly less than non-diabetics. HP infection probably plays a prominent role in development of epigastric pain in patients with T2DM. Additionally, HP is linked to SIBO, which may lead to bloating, belching and nausea onset.

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Association of Helicobacter Pylori Infection and Diabetes Mellitus Type 2 Subjects in Yaounde Cameroon Using a Panel of Serum Biomarkers (PGII, HpIgG): A Case Control Study

Cited by 6 publications

References 2 publications

Helicobacter pylori infection among type 2 diabetics: a case control study

Helicobacter pylori infection among type 2 diabetics: a case control study

Prevalence of Helicobacter pylori infection among type 2 diabetes mellitus

Do H. Pylori Status and Small Intestinal Bacterial Overgrowth Determine the Clinical Course of Chronic Active Gastritis in Patients With Type 2 Diabetes Mellitus?

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