Association of Helicobacter pylori with central serous chorioretinopathy: hypotheses regarding pathogenesis

Giusti, C

doi:10.1016/j.mehy.2004.02.020

Cited by 44 publications

(30 citation statements)

References 21 publications

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“…Immune-mediated damage to choroidal endothelial cells resulting from molecular mimicry is one proposed mechanism. 65 The largest series to date found H. pylori infection in 31/78 (40%) French CSC patients versus a 25% infection rate in the general population (p=0.0036). 3 Kitzmann and colleagues, however, found no patients with a known history of H. pylori infection in their 74 cases.…”

Section: Pathophysiologymentioning

confidence: 93%

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Central Serous Chorioretinopathy: Update on Pathophysiology and Treatment

Nicholson

Noble

Forooghian

et al. 2013

Survey of Ophthalmology

562

573

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Recent technological advances have led to an improved understanding of central serous chorioretinopathy (CSC): new pathophysiological insights, new imaging techniques for diagnosis and management, and new treatments. The primary role of the choroid has become more widely accepted with widespread use of indocyanine green angiography. Optical coherence tomography (OCT), and particularly enhanced depth imaging OCT, demonstrate a thickened and engorged choroid. Adaptive optics, fundus autofluorescence, multifocal electroretinography, microperimetry, and contrast sensitivity testing reveal that patients with even a mild course suffer previously undetected anatomic and functional loss. While focal laser and photodynamic therapy are the current standard of care for persistent subretinal fluid in CSC, they are not appropriate in all cases, and the optimal timing of intervention remains unclear.

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Section: Pathophysiologymentioning

confidence: 93%

“…65 The first report suggesting a relationship between H. pylori infection and CSC was a case report that described a patient with chronic recurrent CSC that seemed to wax and wane with infection and re-treatment. 64 The one, randomized, unmasked trial of H. pylori treatment is discussed above.…”

Section: Treatmentmentioning

confidence: 99%

Central Serous Chorioretinopathy: Update on Pathophysiology and Treatment

Nicholson

Noble

Forooghian

et al. 2013

Survey of Ophthalmology

562

573

View full text Add to dashboard Cite

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“…It has been posited that an immune response to host proteins of the choroidal vasculature and RPE may be caused by molecular mimicry with antigens of H. pylori (Giusti 2004). …”

Section: Introductionmentioning

confidence: 99%

Interventions for central serous chorioretinopathy: a network meta-analysis

Salehi

Wenick

Law

et al. 2015

Cochrane Database of Systematic Reviews

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Background Central serous chorioretinopathy (CSC) is characterized by serous detachment of the neural retina with dysfunction of the choroid and retinal pigment epithelium (RPE). The effects on the retina are usually self limited, although some people are left with irreversible vision loss due to progressive and permanent photoreceptor damage or RPE atrophy. There have been a variety of interventions used in CSC, including, but not limited to, laser treatment, photodynamic therapy (PDT), and intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents. However, it is not known whether these or other treatments offer significant advantages over observation or other interventions. At present there is no evidence-based consensus on the management of CSC. Due in large part to the propensity for CSC to resolve spontaneously or to follow a waxing and waning course, the most common initial approach to treatment is observation. It remains unclear whether this is the best approach with regard to safety and efficacy. Objectives To compare the relative effectiveness of interventions for central serous chorioretinopathy. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2015, Issue 9), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to February 2014), EMBASE (January 1980 to October 2015), the ISRCTN registry (www.isrctn.com/editAdvancedSearch), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 5 October 2015. Selection criteria Randomized controlled trials (RCTs) that compared any intervention for CSC with any other intervention for CSC or control. Data collection and analysis Two review authors independently selected studies and extracted data. We pooled data from all studies using a fixed-effect model. For interventions applied to the eye (i.e. not systemic interventions), we synthesized direct and indirect evidence in a network meta-analysis model. Main results We included 25 studies with 1098 participants (1098 eyes) and follow-up from 16 weeks to 12 years. Studies were conducted in Europe, North and South America, Middle East, and Asia. The trials were small (most trials enrolled fewer than 50 participants) and poorly reported; often it was unclear whether key aspects of the trial, such as allocation concealment, had been done. A substantial proportion of the trials were not masked. The studies considered a variety of treatments: anti-VEGF (ranibizumab, bevacizumab), PDT (full-dose, half-dose, 30%, low-fluence), laser treatment (argon, krypton and micropulse laser), beta-blockers, carbonic anhydrase inhibitors, Helicobactor pylori treatment, and nutritional supplements (Icaps, lutein); there were only one or two tri...

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“…Peptic ulcer was highly correlated with CSR in our study. [16][17][18][19][20] Recent studies have shown that H. pylori infection may be a systemic disease, in addition to peptic ulcer disease, associated with gastric cancer, MALT lymphoma, 21,22 and abnormal gastroesophageal reflux. Abnormal gastroesophageal reflex, such as peptic ulcer disease, which is also one of the complications of Helicobacter pylori infection, has been noted to be associated with CSR.…”

Section: Discussionmentioning

confidence: 99%