Association of Helicobacter Pylori with Presence of Myocardial Infarction in Iran: A Systematic Review and Meta-Analysis

Rahmani, Yousef; Mohammadi, Sareh; Babanejad, Mehran; Rai, Alireza; Zalei, Bahar; Shahmohammadi, Afshar

doi:10.4314/ejhs.v27i4.15

Cited by 24 publications

(19 citation statements)

References 22 publications

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“…Several studies have been published on H. pylori and cardiovascular disease; the most recent meta-analyses in 2017 by Yu et al [41] reported a significant association with coronary artery disease, and by Rahmani et al [42] with myocardial infarction. It has been hypothesized that H. pylori may facilitate atherosclerosis by promoting chronic inflammation, dyslipidemia and endothelial dysfunction [41].…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic, Lifestyle and Medical Factors Associated with Helicobacter Pylori Infection

Ražuka-Ebela

Poļaka

Parshutin

et al. 2020

JGLD

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Background and Aims: The prevalence of Helicobacter pylori (H. pylori) infection is higher in developing countries and is often linked to lower socioeconomic status. Few studies have investigated the association between H. pylori and individual level characteristics in Europe, where several countries have a high prevalence of H. pylori infection. The study aimed to identify risk factors for H. pylori infection among adults in a large clinical trial in Latvia. Methods: 1,855 participants (40-64 years) of the “Multicenter randomized study of H. pylori eradication and pepsinogen testing for prevention of gastric cancer mortality” (GISTAR study) in Latvia tested for H. pylori IgG antibodies were included in a cross-sectional analysis. Sociodemographic, lifestyle and medical factors were compared for participants seropositive (H. pylori+) and seronegative. Mutually adjusted odds ratios (OR) were calculated for H. pylori+ and factors significant in univariate analysis (education, smoking, binge drinking, several dietary habits, history of H. pylori eradication and disease), adjusting for age, gender and income. Results: Of the participants 1,044 (55.4%) were H. pylori seropositive. The infection was associated with current (OR: 1.34, 95%CI: 1.01-1.78) and former (OR: 1.38; 95%CI: 1.03-1.85) smoking, binge drinking (OR: 1.35; 95%CI: 1.03-1.78), having ≥200g dairy daily (OR: 1.37; 95%CI: 1.11-1.69), and very hot food/drinks (OR: 1.32; 95%CI: 1.03-1.69) and inversely with ≥400g vegetables/fruit daily (OR: 0.76; 95%CI: 0.60-0.96), history of H. pylori eradication (OR: 0.57; 95%CI: 0.39-0.84), peptic ulcer (OR: 0.55; 95%CI: 0.38-0.80) and cardiovascular disease (OR: 0.78; 95%CI: 0.61-0.99). Conclusions: After mutual adjustment, H. pylori seropositivity was associated with lifestyle and in particular dietary factors rather than socioeconomic indicators in contrast to the majority of other studies.

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Section: Discussionmentioning

confidence: 99%

Sociodemographic, Lifestyle and Medical Factors Associated with Helicobacter Pylori Infection

Ražuka-Ebela

Poļaka

Parshutin

et al. 2020

JGLD

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“…To it, H. pylori ‐positive geriatric patients have increased risk of developing atherosclerosis and acute coronary syndrome (Carvalho et al, ; Lai, Yang, Lin, & Kao, ). They are also at the risk of acquiring myocardial infraction, stroke, and peripheral artery disease (Rahmani et al, ; Vijayvergiya & Vadivelu, ).…”

Section: Cardiovascular Diseases (Cvd)mentioning

confidence: 99%

Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

Zendehdel

Roham

2020

Molec Gen & Gen Med

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This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. AbstractHelicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Elderly people tend to resist eradication treatment and worsening of infection can lead to several gastric and non-gastric pathologies.Aging-associated cellular and molecular alteration can increase the risk of other pathologies such as osteoporosis, Alzheimer's disease, Parkinson's disease, respiratory and renal dysfunction, and cancer in geriatric patients, more than other age groups.This review article highlights some of the most common old age diseases and the role of H. pylori infection as a risk factor to worsen the conditions, presented by the molecular evidences of these associations. These studies can help clinicians to understand the underlying pathogenesis of the disease and identify high-risk patients, aiding clearer diagnosis and treatment.

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“…However, H. pylori was not isolated from any atherosclerotic plaques in the studies in Italy and Poland [97][98]. Rahmani et al demonstrated in their meta-analysis study that there was a signi cant relationship between the infection with H. pylori and Myocardial infraction in the Iranian patients (ORs = 2.53) [99]. In a meta-analysis of 18 epidemiological studies Danesh et al found no signi cant relationship between H. pylori infection and the coronary heart disease (CHD) [100].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis on the Relation Between Helicobacter Pylori Infection and Atherosclerosis in the Iranian Population

Keikha¹

2020

Preprint

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Background: Various evidences have recently been provided indicating the relationship between infection with Helicobacter pylori and the extra-gastric complication, especially atherosclerosis. Atherosclerosis is the most important predisposing factor for cardiovascular disorders due to the high prevalence of cardiovascular disorders in developing countries (areas where a high population of people are infected with Helicobacter pylori), in particular in Iran.Methods: In a current systematic review and meta-analysis study, we collected all studies of the isolation of Helicobacter pylori from atherosclerotic plaques in Iranian cardiovascular patients to investigate the presence or absence of a relationship between Helicobacter pylori infection and susceptibility to atherosclerosis. The present meta-analysis was done by Comprehensive Meta-Analysis software (CMA-Ver. 2.0). This software has the ability to combine studies and impact sizes into the results and is highly acceptable.Results: Overall, the frequency of H. pylori in atherosclerotic plaques in the coronary artery disease (CAD) patients was estimated to be 41.30%. However, the highest and lowest frequency of infection with Helicobacter pylori were 80% and 0%, respectively.Conclusions: However generally, regarding the previous studies, we collected all the Iranian published articles and showed that the infection with Helicobacter pylori was significantly related with the atherosclerosis, but further complementary and more extensive studies are required to confirm this hypothesis.

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Association of Helicobacter Pylori with Presence of Myocardial Infarction in Iran: A Systematic Review and Meta-Analysis

Cited by 24 publications

References 22 publications

Sociodemographic, Lifestyle and Medical Factors Associated with Helicobacter Pylori Infection

Sociodemographic, Lifestyle and Medical Factors Associated with Helicobacter Pylori Infection

Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

A Systematic Review and Meta-Analysis on the Relation Between Helicobacter Pylori Infection and Atherosclerosis in the Iranian Population

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