Association of Hepatitis C Virus Infection With Risk of ESRD: A Population-Based Study

Su, Fu Hsiung; Su, Chien Tien; Chang, Shih Ni; Chen, Pei Chun; Sung, Fung Chang; Lin, Cheng Chieh; Yeh, Chih Ching

doi:10.1053/j.ajkd.2012.04.003

Cited by 47 publications

(67 citation statements)

References 38 publications

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“…Regarding urbanization level, our data showed that more HCV-infected patients resided in rural areas. Both of these results were similar to those reported by previous research [5,6,27].…”

Section: Discussionsupporting

confidence: 93%

“…Numerous recent studies have shown evidence of various extrahepatic manifestations of HCV infection. HCV-infected patients are at high risk of stroke, hypertension (HTN), metabolic syndrome, chronic kidney disease (CKD), and end-stage renal disease (ESRD) [3][4][5][6]. Furthermore, prospective and retrospective studies have consistently reported excess risk of developing type-2 diabetes mellitus (DM) in HCV-infected patients [7].…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis C virus infection increases the risk of developing peripheral arterial disease: A 9-year population-based cohort study

Hsu

Muo

Liu

et al. 2015

Journal of Hepatology

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“…Regarding urbanization level, our data showed that more HCV-infected patients resided in rural areas. Both of these results were similar to those reported by previous research [5,6,27].…”

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Hepatitis C virus infection increases the risk of developing peripheral arterial disease: A 9-year population-based cohort study

Hsu

Muo

Liu

et al. 2015

Journal of Hepatology

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“…The studies were published in 17 various articles [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] and carried out in 4 countries ( Fig. 1) (n = 2,842,421 unique patients).…”

Section: Literature Reviewmentioning

confidence: 99%

“…There was a 100 % concordance between reviewers with respect to final inclusion and exclusion of studies reviewed based on the predefined inclusion and exclusion criteria. Diagnosis of HCV infection was mostly made by testing for anti-HCV antibody in serum and/or HCV RNA detection by polymerase chain reaction; in a few reports [21,23,24], diagnosis of HCV infection was done by ICD-9 codes.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Nine longitudinal studies (n = 1,947,034 unique patients; 223,150 HCV-positive and 1,723,884 HCV-negative patients) gave information on the incidence of CKD among HCV-positive patients [18][19][20][21][22][23][24][25][26] (Table 1). We found a significant relationship between positive anti-HCV serologic status and increased incidence of CKD, adjusted HR with HCV across the surveys, 1.43 (95 % CI 1.23; 1.63, P = 0.0001) (Fig.…”

Section: Summary Estimate Of Outcome: Incidence Of Ckd (Reduced Egfr)mentioning

confidence: 99%

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Hepatitis C Virus Infection Increases the Risk of Developing Chronic Kidney Disease: A Systematic Review and Meta-Analysis

et al. 2015

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Association of hepatitis C viral infection with incidence and progression of chronic kidney disease in a large cohort of US veterans

et al. 2015

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Background An estimated 4 million Americans have been exposed to the hepatitis C virus (HCV) in the US population. The risk of incident and progressive chronic kidney disease and of mortality in patients with normal kidney function infected with HCV is unclear. Methods In a nationally representative cohort of 100,518 HCV+ and 920,531 HCV- US Veterans with normal baseline estimated glomerular filtration rate(eGFR), we examined the association of HCV infection with: (1)all-cause mortality, (2)incidence of decreased kidney function (defined as eGFR <60 ml/min/1.73m2 and 25% decrease in eGFR), (3)ESRD, and (4)rate of kidney function decline. Associations were examined in naïve and adjusted Cox models (for time-to-event analyses) and logistic regression models (for slopes), with sequential adjustments for important confounders. Propensity-matched cohort analysis was used in sensitivity analyses. Results The patients’ age was 54.5±13.1(mean±SD) years, 22% were black and 92% male, and the baseline eGFR was 88±16 ml/min/1.73m2. In multivariate adjusted models HCV infection was associated with 2.2 fold higher mortality (fully adjusted hazard ratio(aHR), 95%CI: 2.17(2.13–2.21)), 15% higher incidence of decreased kidney function(aHR, 95%CI: 1.15(1.12–1.17)), 22% higher risk of steeper slopes of eGFR (adjusted odds ratio, 95%CI: 1.22(1.19–1.26)) and 98% higher hazard of ESRD (aHR, 95%CI: 1.98 (1.81–2.16)). Quantitatively similar results were found in propensity-matched cohort analyses. Conclusions HCV infection is associated with higher mortality risk, incidence of decreased kidney function and progressive loss of kidney function. Randomized controlled trials are warranted to determine whether treatment of HCV infection can prevent the development and progression of CKD and improve patient outcomes.

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Association of Hepatitis C Virus Infection With Risk of ESRD: A Population-Based Study

Cited by 47 publications

References 38 publications

Hepatitis C virus infection increases the risk of developing peripheral arterial disease: A 9-year population-based cohort study

Hepatitis C virus infection increases the risk of developing peripheral arterial disease: A 9-year population-based cohort study

Hepatitis C Virus Infection Increases the Risk of Developing Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Association of hepatitis C viral infection with incidence and progression of chronic kidney disease in a large cohort of US veterans

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