Association of high-density lipoprotein cholesterol and periodontitis severity in Chinese elderly: a cross-sectional study

Zhu, Haihua; Ye, Guanchen; Xie, Yanyi; Zhu, Kangqi; Zhu, Fengsen; Chen, Qianming

doi:10.1007/s00784-022-04439-4

Cited by 8 publications

(4 citation statements)

References 42 publications

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“…An increased LDL/HDL ratio was independently associated with long-term coronary revascularization in AMI patients 17) . The previous studies reported that the severity of PD was correlated with lower HDL cholesterol levels and apolipoprotein A1 levels 18,19) . Similar to these reports, in the present study, the HDL cholesterol and apolipoprotein A1 levels were numerically lower from healthy to mild-moderate PD to severe PD in the AMI patients.…”

Section: Discussionmentioning

confidence: 97%

The Relationship between Severity of Periodontitis and Atherosclerotic Cardiovascular Status in Patients with Acute Myocardial Infarctions: A Cross-sectional Study

Arai,

Fujiwara,

Kojima

et al. 2023

Nichidai Igaku Zasshi

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Background: Although the associations between periodontitis (PD) and acute myocardial infarctions (AMIs) are known, it is unclear whether the severity of PD is correlated with atherosclerotic cardiovascular status (ASCVS) in patients with AMIs. Methods: This was a cross-sectional study. We investigated 50 patients with AMI admitted to Nihon University Itabashi Hospital from July 2019 to May 2022. All patients were classified according to the presence and severity of PD. The periodontal status was defined by radiographic bone loss in accordance with previous studies (healthy; ≥ 80% remaining bone [RB], mild-moderate PD; 66 ≤ RB < 80%, and severe PD; RB < 66%), and the degree of ASCVS was compared. Results: The frequency of tooth loss ≥ 5 was significantly higher, and the mean probing pocket depth was numerically higher from healthy to mild-moderate PD to severe PD. The low-density lipoprotein/high-density lipoprotein ratio significantly increased from healthy to mild-moderate PD to severe PD. The carotid intima-media thickness was numerically higher in the severe PD group. The early diastolic velocity to early diastolic myocardial velocity (E/e') ratio was significantly higher in severe PD and had a weak negative correlation with the severity of PD (r = −0.411, p = 0.003). Conclusions: We found that the severity of PD was correlated with the E/e' ratio in AMI patients.

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Section: Discussionmentioning

confidence: 97%

The Relationship between Severity of Periodontitis and Atherosclerotic Cardiovascular Status in Patients with Acute Myocardial Infarctions: A Cross-sectional Study

Arai,

Fujiwara,

Kojima

et al. 2023

Nichidai Igaku Zasshi

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“…The high-density lipoprotein cholesterol (HDL-C), a lipid with anti-inflammatory and antioxidant properties, can modulate innate and adaptive immune responses 15 . It has been suggested that periodontal pathogenic bacteria, along with the resulting metabolites and pro-inflammatory cytokines from periodontal infection, may contribute to HDL metabolism impairment and peroxidation 16 , 17 . While numerous studies have reported a significant decrease in HDL levels among patients with periodontitis, it is worth noting that some research has not found a statistically significant difference in HDL between patients with periodontitis and those without 18 – 21 .…”

Section: Introductionmentioning

confidence: 99%

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and prevalence of periodontitis among US adults: a cross-sectional NHANES study

Hou,

Song,

et al. 2024

Sci Rep

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The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a recently developed lipid parameter, but there is currently a lack of research exploring its relationship with periodontitis. This study aims to identify the potential association between NHHR and periodontitis. The association between NHHR and periodontitis were examined through univariate and multivariate weighted logistic regression utilizing the National Health and Nutrition Examination Survey data from 2009 to 2014. The participants were grouped based on the type of periodontitis. This study included a total of 9023 participants, with 1947 individuals having no periodontitis, and an additional 7076 individuals suffering from periodontitis. Patients in periodontitis group demonstrated a statistically significant elevation in NHHR values 2.82 (2.05–3.80) compared to those in no periodontitis group (p < 0.001). Logistic regression analysis of variables demonstrated a positive association between NHHR and periodontitis [1.07 (1.02, 1.12) p = 0.0067]. The study revealed a positive association between NHHR and an elevated prevalence of periodontitis development. For each unit increase in NHHR, there is a 7% increase in the prevalence of periodontitis. Further investigations into NHHR may enhance our understanding of preventing and treating periodontitis. However, additional studies are required to validate these findings.

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“…Whether and how lipid abnormalities affect the development of periodontitis through other common pathways needs to be further explored. Observational studies investigating this topic do not present enough power to reach concrete conclusions [ 6 , 8 ]. Therefore, we aimed to explore the pathways between dyslipidemia and periodontitis in a nationally representative sample of US adults from the Third National Health and Nutrition Examination Survey (NHANES III) [ 9 ], using a structural equation modelling (SEM) approach.…”

Section: Introductionmentioning

confidence: 99%

The Role of Dyslipidemia in Periodontitis

et al. 2023

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Studies have suggested an important role of dyslipidemia, a condition with alterations in blood lipid levels, in promoting an additional effect on periodontal breakdown. Thus, this study aimed to explore the theoretical pathways associated with dyslipidemia and periodontitis. We used data from 11,917 US adults with complete periodontal examinations participating in the Third National Health and Nutrition Examination Survey (NHANES III). Our hypothesis was tested using structural equation modelling (SEM). Dyslipidemia was defined according to the National Cholesterol Education Program (NCEP-ATP III) and periodontitis as a latent variable reflecting the shared variance of the number of surfaces with periodontal pocket depth [PPD] = 4 mm, PPD = 5 mm, PPD ≥ 6 mm, clinical attachment level [CAL] = 4 mm, CAL = 5mm, CAL ≥ 6 mm, and furcation involvement. The model also considered distal determinants (age, sex, and socioeconomic status) and proximal determinants (HbA1c, smoking and alcohol consumption, and obesity). The model showed sufficient global fit (Root Mean Squared Error of Approximation = 0.04, 90%CI = 0.04–0.05, Tucker–Lewis Index = 0.93, Comparative Fit Index = 0.95). Age, sex, socioeconomic status, obesity, and smoking were directly associated with periodontitis (p < 0.01). Dyslipidemia revealed a significant direct effect on periodontitis (standardized coefficient [SC] = 0.086, SE 0.027; p < 0.01), also mediated via an indirect pathway through HbA1c (SC = 0.021; SE 0.010; p = 0.02) and obesity (SC = 0.036; SE 0.012; p < 0.01) and resulted in a total effect on periodontitis. Dyslipidemia was associated with periodontitis through a direct pathway and indirectly through HbA1c and obesity in the US population. These results support the need for a multi-professional approach to tackling oral and noncommunicable diseases (NCDs), directed at their common risk factors.

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Association of high-density lipoprotein cholesterol and periodontitis severity in Chinese elderly: a cross-sectional study

Cited by 8 publications

References 42 publications

The Relationship between Severity of Periodontitis and Atherosclerotic Cardiovascular Status in Patients with Acute Myocardial Infarctions: A Cross-sectional Study

The Relationship between Severity of Periodontitis and Atherosclerotic Cardiovascular Status in Patients with Acute Myocardial Infarctions: A Cross-sectional Study

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and prevalence of periodontitis among US adults: a cross-sectional NHANES study

The Role of Dyslipidemia in Periodontitis

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