Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension

Lee, Minwoo; Lim, Hyung Bin; Koo, Hyung-Moon; Lee, Younghoon; Kim, Jung‐Yeul

doi:10.1371/journal.pone.0256131

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…Meanwhile, greater peripapillary RNFL damage has been also reported when high myopia and hypertension were both present. Lee et al 24 hypothesized that, together, mechanical stretching caused by high myopia and ischemic damage induced by hypertension would lead to a greater reduction in peripapillary RNFL thickness than ischemic or mechanical damage alone. Overall, when high myopia is present together with systemic disease, which damages the inner retina, inner retinal thinning will be accelerated.…”

Section: Discussionmentioning

confidence: 99%

Impact of high myopia on inner retinal layer thickness in type 2 diabetes patients

Kim

Lee

et al. 2023

Sci Rep

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To investigate the impact of the combination of type 2 diabetes (DM) and high myopia on inner retinal layer thickness of the macular area. The patients were divided into four groups: control (group 1), patients with DM without high myopia (group 2), patients with high myopia without DM (group 3), and patients with DM and high myopia (group 4). Ganglion cell complex (GCC) thickness was compared among the groups. Linear regression analysis was performed to identify factors associated with GCC thickness. A total of 194 eyes were enrolled: 59 in group 1, 52 in group 2, 49 in group 3, and 34 in group 4. The average parafovea GCC thicknesses were 113.9 ± 10.4, 112.4 ± 11.2, 112.2 ± 7.8, and 102.6 ± 15.1 μm (P < 0.001), and the average perifovea GCC thicknesses were 104.8 ± 13.2, 103.5 ± 10.8, 103.6 ± 8.8, and 93.9 ± 15.5 μm in groups 1, 2, 3 and 4, respectively (P = 0.001). In multivariate analyses, age (β = − 0.20, P = 0.007), DM duration (β = − 0.34, P = 0.023), and axial length (β = − 1.64, P < 0.001) were significantly associated with parafoveal GCC thickness. The GCC was significantly thinner when high myopia and DM were combined, compared to either condition alone. Additionally, age, DM duration, and axial length were significant factors associated with GCC thickness. The combination of mechanical stretching and neurodegeneration would accelerate neural damage to the retina, resulting in greater inner retinal layer thinning.

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Section: Discussionmentioning

confidence: 99%

Impact of high myopia on inner retinal layer thickness in type 2 diabetes patients

Kim

Lee

et al. 2023

Sci Rep

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“…High myopia refers to ametropia characterized by extension of optic axis and retinal and choroidal degeneration in the fundus, and high myopia patients present with various degrees of structural and functional retinal changes and thinning of the retinal thickness, with thinning and degeneration of retina in the posterior pole being more pronounced [ 13 , 14 ]. Previous studies considered high myopia to be associated with increased diopter but often ignored retinopathy conditions, resulting in patients losing optimal treatment timing.…”

Section: Discussionmentioning

confidence: 99%

Value of Combining Optical Coherence Tomography with Fundus Photography in Screening Retinopathy in Patients with High Myopia

Hao

Liu

2022

Journal of Healthcare Engineering

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Objective. To explore the value of combining optical coherence tomography (OCT) with fundus photography in screening retinopathy in patients with high myopia. Methods. By means of retrospective study, 40 high myopia patients with retinopathy treated in our hospital from January 2020 to January 2021 were selected as the study group, and 40 healthy individuals in the same period were included in the control group. All patients received traditional ophthalmic examination, and accepted fundus fluorescence imaging, OCT, and fundus photography examination step by step by the same operator. After that, three physicians read the slides by the double blind method, and took the results of fundus fluorescence imaging as the gold standard to analyze the diagnostic efficacy of OCT, fundus photography and their combination. Results. The clinical data and examination results showed that no statistical differences in general data including patients’ mean age, gender ratio, and educational degree between the study group and the control group were observed (P > 0.05), and the nerve thickness above/below the optic disk and temporal/nasal nerve thickness of the optic disk of the study group were significantly different from those of the control group (P < 0.001); the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy rate of diagnosis of combining OCT with fundus photography were respectively 95.0%, 97.5%, 97.4%, 95.1%, and 96.3%, which were significantly higher than OCT or fundus photography alone (P < 0.05); and for combined examination, AUC (95%CI) = 0.963 (0.000–1.000). Conclusion. Combining OCT with fundus photography can effectively identify high myopia patients with retinopathy, which is conducive to improving clinical positive ratio and providing objective basis for treatment.

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“…RNFL thinning has been previously reported in patients with OSA, along with decreased visual evoked potentials [ 9 , 10 , 31 – 47 , 56 ]. Importantly, while RNFL thinning has been reported in myopic eyes and associated with health conditions including migraines, diabetes, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease, this usually results in more diffuse thinning [ 57 – 62 ]. In contrast, the pattern of thinning shown in this study is consistent with glaucomatous changes that follow an ISNT (inferior, superior, nasal, and then temporal) pattern.…”

Section: Discussionmentioning

confidence: 99%

Differential effects of obstructive sleep apnea on the corneal subbasal nerve plexus and retinal nerve fiber layer

et al. 2022

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Purpose Obstructive sleep apnea (OSA) is an established independent risk factor for peripheral neuropathy. Macro and microvascular changes have been documented in OSA, including high levels of potent vasoconstrictors. In diabetes, vasoconstriction has been identified as an underlying risk factor for corneal neuropathy. This study sought to establish a potential relationship between OSA and corneal nerve morphology and sensitivity, and to determine whether changes in corneal nerves may be reflective of OSA severity. Design Single center cross-sectional study. Methods Sixty-seven patients were stratified into two groups: those with OSA and healthy controls. Groups were matched for age, sex, race, smoking, and dry eye status. Outcome measures included serologies, a dilated fundus exam, dry eye testing, anthropometric parameters, corneal sensitivity, subbasal nerve plexus morphology, retinal nerve fiber layer (RNFL) thickness, and the use of questionnaires to assess symptoms of dry eye disease, risk of OSA, and continuous positive airway pressure (CPAP) compliance. Results No significant differences were observed in corneal nerve morphology, sensitivity, or the number of dendritic cells. In the OSA test group, RNFL thinning was noted in the superior and inferior regions of the optic disc and peripapillary region. A greater proportion of participants in the OSA group required a subsequent evaluation for glaucoma than in the control. In those with OSA, an increase in the apnea hypopnea index was associated with an increase in optic nerve cupping. Conclusions OSA does not exert a robust effect on corneal nerves. OSA is however, associated with thinning of the RNFL. Participants with glaucomatous optic nerve changes and risk factors for OSA should be examined as uncontrolled OSA may exacerbate glaucoma progression.

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Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension

Cited by 6 publications

References 20 publications

Impact of high myopia on inner retinal layer thickness in type 2 diabetes patients

Impact of high myopia on inner retinal layer thickness in type 2 diabetes patients

Value of Combining Optical Coherence Tomography with Fundus Photography in Screening Retinopathy in Patients with High Myopia

Differential effects of obstructive sleep apnea on the corneal subbasal nerve plexus and retinal nerve fiber layer

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