Association of high-sensitive C-reactive protein with advanced stage β-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus

Pfützner, Andreas; Standl, Eberhard; Strotmann, Hermann-Josef; Schulze, Jan; Hohberg, C.; Lübben, G.; Pahler, S.; Schöndorf, Thomas; Forst, Thomas

doi:10.1515/cclm.2006.108

Cited by 37 publications

(40 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among inflammatory biomarkers, the best evidence to date supports the use of hs-CRP as an independent predictor of increased CVD risk in diabetic and non-diabetic patients. In addition, numerous clinical trials have established elevated CRP levels to be predictive of the development of insulin resistance, metabolic syndrome, and T2DM [7]. Our results are similar to another study [8] which reported that acute phase response was present in patients with type-2 diabetes.…”

Section: Discussionsupporting

confidence: 89%

“…Large prospective studies pointed out the involvement of increased hs-CRP on cardiovascular morbidity and mortality in these patients. High levels of hs-CRP have been shown to be an independent predictor of cardiovascular risk for all degrees of severity of metabolic syndrome and T2DM [7], [9], and [10]. Regarding CIMT, there was a significant difference between patient groups and the control with mean CIMT in group I was 1.2±0.16, in group-II was 1.2±0.18 and in group-III was 0.5±0.1.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus

Mizar

Hussein

Mashaheet

et al. 2014

International Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

Background: Type 2 diabetes mellitus (T2DM) is an inflammatory atherosclerotic condition with high prevalence of cardiovascular disease. Elevated C-reactive protein (CRP) predicts cardiovascular events in T2DM patients. Objectives: Our work aimed to assess sensitivity and specificity of CRP in diagnosis and follow up of carotid atherosclerosis in T2DM patients (detected by measuring carotid intima-media thickness CIMT). Design and setting: It is observational cross sectional study on T2DM patients from outpatient clinic of fayoum university hospital. Subjects and methods: Hundred patients with T2DM were included; Group I: statin un-treated, Group II: statin treated, and fifty healthy control persons. Laboratory measurement of total cholesterol, LDL, HDL, and serum CRP levels and carotid duplex scanning were done. Results: The patients had higher levels of CRP and CIMT than control. There was strong correlation between CIMT and CRP level among group I and II. LDL in diagnosis of atherosclerosis disease illustrated sensitivity (80%) and specificity (4%), while HDL sensitivity (96%) and specificity (36%). CRP showed higher sensitivity (98%) and higher specificity (72%). Conclusion: CRP level was an important parameter of atherosclerosis with good sensitivity and specificity regardless the level of LDL and HDL.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 97%

Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus

Mizar

Hussein

Mashaheet

et al. 2014

International Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Results demonstrated that increased hs-CRP levels were linked to homeostatic model assessment, intact proinsulin, insulin, body mass index (BMI), and β-cell dysfunction (all p < 0.001) (Figure 3), but showed no correlation with disease duration or glucose control. 19 Another cross-sectional trial of participants in the Women's Health Study correlated hs-CRP with insulin resistance in nondiabetic women. The odds ratio for having elevated fasting insulin increased with each tertile of hs-CRP.…”

Section: High-sensitivity C-reactive Protein Correlates With Insulin mentioning

confidence: 99%

High-Sensitivity C-Reactive Protein Predicts Cardiovascular Risk in Diabetic and Nondiabetic Patients: Effects of Insulin-Sensitizing Treatment with Pioglitazone

Pfützner

Schöndorf

Hanefeld

et al. 2010

J Diabetes Sci Technol

Self Cite

View full text Add to dashboard Cite

Abbreviations: (BMI) body mass index, (CVD) cardiovascular disease, (HbA1c) hemoglobin A1c, (HOMA) homeostasis model assessment, (hs-CRP) high-sensitivity C-reactive protein, (LDL) low-density lipoprotein, (PPARγ) peroxisome proliferator-activated receptor-γ Keywords: atherosclerosis, diabetes, hs-CRP, inflammation, insulin resistance, pioglitazone AbstractSystemic inflammatory activity has turned out to play a key pathogenic role in vascular atherosclerosis, insulin resistance, and type 2 diabetes mellitus. Inflammatory biomarkers may therefore be a valuable tool for risk evaluation. Among them, the best evidence to date supports the use of high-sensitivity C-reactive protein (hs-CRP) to monitor insulin resistance and cardiovascular risk in diabetic and nondiabetic individuals. Data suggest that hs-CRP may also participate directly in the process of atherogenesis. A growing number of clinical trials tested the hypothesis that antidiabetic drugs specifically targeting insulin resistance could benefit individuals by reducing inflammation, atherogenesis, and thus cardiovascular risk. One such class are the thiazolidinediones (pioglitazone and rosiglitazone). These agents act as selective ligands of the nuclear transcription factor peroxisome proliferator-activated receptor-γ (PPARγ). This article reviewed published data on hs-CRP changes with the thiazolidinedione agent pioglitazone. Here we found pronounced insulin-sensitizing and anti-inflammatory properties in different clinical settings, including diabetic and nondiabetic individuals. Coadministration of pioglitazone to antilipidemic statin therapy resulted in additional effects on low-grade inflammation, and hs-CRP reduction has been demonstrated to occur independently of glucose lowering. The anti-inflammatory effect appeared to be a rapid physiologic reaction on PPARγ activation and could be observed within a short-term interval after starting pioglitazone therapy. In summary, clinical study results underline the benefit of an early insulin resistance treatment to oppose systemic vascular inflammation and cardiometabolic syndrome in patients with elevated levels of high-sensitivity C-reactive protein.

show abstract

“…117,118 For example, CRP significantly inhibits cell proliferation and increases the rates of apoptotic cell death. 119 This effect was connected to the CRP-mediated modulation of protein kinase B (PKB), a key factor for cell survival pathways and to its ability to induce the production of TNF-α, IL-1β and matrix metalloproteinase-9 (MMP-9) in a concentration-dependent manner.…”

mentioning

confidence: 99%

Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention

Badawi¹,

Klip²,

Haddad³

et al. 2010

DMSO

123

View full text Add to dashboard Cite

Association of high-sensitive C-reactive protein with advanced stage β-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus

Cited by 37 publications

References 32 publications

Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus

Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus

High-Sensitivity C-Reactive Protein Predicts Cardiovascular Risk in Diabetic and Nondiabetic Patients: Effects of Insulin-Sensitizing Treatment with Pioglitazone

Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention

Contact Info

Product

Resources

About