Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is highsensitivity C-reactive protein (hsCRP). Methods: This cross-sectional study attempted to analyze the association of hsCRP levels with insulin resistance, b-cell dysfunction and macrovascular disease in 4270 non-insulin-treated patients with type 2 diabetes w2146 male, 2124 female; mean age "SD, 63.9"11.1 years; body mass index (BMI) 30.1"5.5 kg/m

Type 2 patients with elevated fasting intact proinsulin values can be regarded as being insulin resistant. The results confirm that fasting intact proinsulin is a suitable measure for beta-cell dysfunction and insulin resistance in type 2 diabetes and may be used to support therapeutic decisions.

The new IRIS II score can identify insulin resistance in Type 2 diabetic patients with high predictive value and high specificity.

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Elevation of fasting intact proinsulin seems to be the more specific marker for insulin resistance and increased cardiovascular risk than suppression of fasting adiponectin. Formation of the ratio does not lead to a further increase in the predictive value.