Association of HLA‐DQB1★0301 and HLA‐DQB1★0602 with Different Subtypes of Gastric Cancer in Taiwan

Wu, Ming–Shiang; Hsieh, Rhong-Phong; Huang, Shu‐Chien; Chang, Yu-Ting; Lin∥, Ming–Tsan; Chang, Ming‐Chu; Shun, Chia‐Tung; Sheu, Jin‐Chuan; Lin, Jaw–Town

doi:10.1111/j.1349-7006.2002.tb01271.x

Cited by 37 publications

(55 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies related to HLA antigens in the literature have focused on screening of class II antigens especially in cancer cases (12,14) . Our study was the (10,11) .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Human Leukocyte Antigen Class I and Ii Antigens in Helicobacter Pylori-Positive Pediatric Patients With Active Gastritis and Duodenal Ulcer

Gönen

Sarı

Kandur

et al. 2017

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Background -As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population. Some earlier studies have found a relation between tissue histocompatibility antigens and gastric cancers depending on the regions. Objective -The present study aimed to determine the distribution of human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer, excluding cancer cases, in our center. Methods -The study included 40 patients diagnosed with H. pylori-positive active gastritis and duodenal ulcer and 100 controls consisting of healthy donor candidates. The HLA class I and class II antigens were studied in the isolated DNA samples using the polymerase chain reaction sequence-specific oligonucleotide probes. Results -The frequency of HLA-B*51 antigen was significantly higher in the patient group than in the control group (40% vs 17%; P=0.003).

show abstract

“…Many studies related to HLA antigens in the literature have focused on screening of class II antigens especially in cancer cases (12,14) . Our study was the (10,11) .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Human Leukocyte Antigen Class I and Ii Antigens in Helicobacter Pylori-Positive Pediatric Patients With Active Gastritis and Duodenal Ulcer

Gönen

Sarı

Kandur

et al. 2017

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

“…Because of its important role in the immune response and high polymorphism, the HLA system is associated with many diseases. Recently, many papers about the association between HLA and many types of tumor have been published, including cervical cancer (Schiff et al, 2005;Madeleine et al, 2008), leukemia (Dorak et al, 2002;Mundhada et al, 2004;Wu et al, 2007;Yari et al, 2008), gastric cancer (Wu et al, 2002;Quintero et al, 2005), ovarian cancer (Kübler et al, 2006), thyroid cancer (Haghpanah et al, 2009), and breast cancer (Cantú de León et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

Yang¹,

Wang²,

Shi³

et al. 2010

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The primary function of the human leukocyte antigen (HLA) system is to regulate the immune response. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-A, B and DRB1 alleles in 100 unrelated patients with lung carcinoma and in 438 unrelated normal controls of Han nationality from North China, using sequencebased typing and PCR with sequence-specific primers. We found that the frequencies of HLA-A*0201, A*2601, B*1518, B*3802, DRB1*0401, DRB1*0402, and DRB1*1201 were higher in the lung carcinoma group than in the normal control group. The P values were 0.035, 0.040, 0.001, 0.017, 0.014, 0.004, and 0.019, respectively, and the odds ratio values were 1. 052, 3.513, 4.047, 3.054, 4.237, 19.397, and 2.128, respectively. The frequency of HLA-DRB1*1302 was lower in the lung carcinoma group than in the normal control group (P = 0.046, odds ratio = 0.168). We concluded that patients with lung

show abstract

“…Some HLA alleles, like -DQB1*0602, have been found at high frequency in H pylori-positive patients favoring gastric cancer occurrence, whereas -DQB1*0301 seems to be protective against cancer in Taiwanese patients. 6 In contrast, other alleles were found to be not associated with H pylori infection and cancer risk in Italian (-DQA1 and -DQB1) and German (-DQA1, -DQB1, and HLA class II) patients, respectively, whereas -DRB1*1501, -DQA1*01021, and -DQB1*0602 seem to be protective against H pylori infection in Japanese patients. 7,8 Similarly, other different alleles were found at high or low frequency in Caucasian, Chinese, Spanish, Greek, and Japanese patients infected with H pylori.…”

Section: Responsementioning

confidence: 90%

“…Liver perfusion studies and modeling of asparaginase treatment suggest that there is a high rate of asparagine input into the circulation from diet and the tissues. 5,6 An equilibrium between the rate of asparagine input and the asparaginase activity can result in a low (nonzero) steady-state asparagine concentration. …”

mentioning

confidence: 99%

Idiopathic thrombocytopenic purpura, Helicobacter pylori infection, and HLA class II alleles

Veneri

Gottardi

Guizzardi

et al. 2002

Blood

View full text Add to dashboard Cite

asparagine concentrations return toward normal much faster when care is taken to inhibit ex vivo enzyme activity. 4 We sent a blinded set of our samples to Dr Asselin, and she confirmed the asparagine values we reported. Liver perfusion studies and modeling of asparaginase treatment suggest that there is a high rate of asparagine input into the circulation from diet and the tissues. 5,6 An equilibrium between the rate of asparagine input and the asparaginase activity can result in a low (nonzero) steady-state asparagine concentration.

show abstract

Association of HLA‐DQB1★0301 and HLA‐DQB1★0602 with Different Subtypes of Gastric Cancer in Taiwan

Abstract: Gastric cancer (GC) is a heterogeneous disorder with multifactorial etiologies. Genetic predisposition, environmental factors, and

Cited by 37 publications

References 35 publications

Evaluation of Human Leukocyte Antigen Class I and Ii Antigens in Helicobacter Pylori-Positive Pediatric Patients With Active Gastritis and Duodenal Ulcer

Evaluation of Human Leukocyte Antigen Class I and Ii Antigens in Helicobacter Pylori-Positive Pediatric Patients With Active Gastritis and Duodenal Ulcer

Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer

Idiopathic thrombocytopenic purpura, Helicobacter pylori infection, and HLA class II alleles

Contact Info

Product

Resources

About