Evaluation of Human Leukocyte Antigen Class I and Ii Antigens in Helicobacter Pylori-Positive Pediatric Patients With Active Gastritis and Duodenal Ulcer

Abstract

-Background -As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population. Some earlier studies have found a relation between tissue histocompatibility antigens and gastric cancers depending on the regions. Objective -The present study aimed to determine the distribution of human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer, excluding cancer cases, in our center. Methods -The study included 40 patients diagnosed with H. pylori-positive active gastritis and duodenal ulcer and 100 controls consisting of healthy donor candidates. The HLA class I and class II antigens were studied in the isolated DNA samples using the polymerase chain reaction sequence-specific oligonucleotide probes. Results -The frequency of HLA-B*51 antigen was significantly higher in the patient group than in the control group (40% vs 17%; P=0.003).

Major Histocompatibility Complex Class I-Related Chain A (MICA) Allelic Variants Associate With Susceptibility and Prognosis of Gastric Cancer

“…The MICA * 009-HLA B * 50, B * 51 or B * 52 haplotypes have been described in previous studies (59)(60)(61). Accordingly, HLA B * 51 was found to be more frequent in Helicobacter pyloripositive pediatric patients with active gastritis and duodenal ulcer (62) and the HLA B * 52 antigen has shown to be associated with lymph node metastasis in gastric cancer (63). Therefore, both HLA-B alleles and MICA * 009/049 could to be factor risk in gastric cancer, so we suggest to consider this information for future studies.…”

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

“…Autoantibodies against proteins in the retina and/or the optic nerve, resulting from the possible molecular mimicry between H. pylori and ocular proteins, might be involved in glaucomatous neuropathy of the optic nerve [63,64]. More specifically, H. pylori antigens stimulate the production of specific antibodies which recognize homologous host protein sequences, such as in glycoproteins, heat-shock proteins (Hsps), H + /K + ATPase, H + /K + -adenosine triphosphatase, Human leukocyte antigens (HLA), chemokine receptors, Lewis antigens, and act as autoantibodies [58,[67][68][69][70]. In this regard, an example could be autoimmune gastritis, in which similarities of H + , K + -ATPase and bacterial epitopes may result in the production of antibodies against parietal cells, thereby suggesting that bacterial infection may be the trigger of an autoimmune mucosal inflammation resulting to mucosa atrophy in patients with chronic H. pylori gastritis [71].…”

Инфекция Helicobacter pylori: ассоциация факторов вирулентности с антигенами HLA-системы II класса (локус DQ A1) у детей, больных язвой двенадцатиперстной кишки

“…Усередині епітеліальної клітини CagA фосфорилюється за залишковим тирозином СРК-кіназами кліти-Оригінальні дослідження / Original Researches ни-хазяїна і стимулює клітинно-сигнальні шляхи [8], що, у свою чергу, викликає ураження клітин і активацію протоонкогенів. VacA є поліморфним, основними алелями сигнальної ділянки є s1 і s2, тоді як алелями середньої ділянки є m1 і m2 [9][10]. VacA -токсин, що зв'язується з декількома рецепторами епітеліальних клітин з утворенням великих вакуолей.…”