Association of HLA-DRB1 Gene Polymorphism with Risk of Asthma: A Meta-Analysis

Yao, Yanwen; Zhu, Lijun; Li, Jie; Jin, Yuelong; He, Lianping

doi:10.12659/msmbr.900193

Cited by 14 publications

(12 citation statements)

References 36 publications

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“…It is widely accepted that airway function is altered by LPS exposure [ 4 – 6 ]. Several studies have shown that LPS exacerbated bronchoconstrictive and inflammatory effects in patients and animal model with allergic asthma, and enhanced antigen-specific allergic responses in the airway, and the severity of asthma is associated with LPS concentration [ 7 – 12 ]. However, recent experiments and epidemiological studies show that LPS protects against asthma [ 6 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide Exposure Alleviates Asthma in Mice by Regulating Th1/Th2 and Treg/Th17 Balance

Ding

Liu

2018

Med Sci Monit

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BackgroundIt is generally believed that endotoxin exposure exacerbates risk of developing asthmatic symptoms. However, recent studies have indicated that prior bacterial exposure may prevent future symptoms of asthma. Here, we evaluated the influence of pre-exposure to different concentrations of lipopolysaccharide (LPS) to subsequent ovalbumin (OVA) allergen sensitization and challenge.Material/MethodsFour-week-old Balb/c mice were treated intranasally with varying concentrations of LPS (1 ug, 10 ug, and 100 ug) or sterile PBS for 10 days, then 2 weeks later they were exposed to OVA. Both the molecular and functional airway responses to OVA administration were assessed following prior exposure to different doses of LPS or controls. Additionally, the Th1/Th2 and Treg/Th17 balance was measured.ResultsAirway responsiveness and immune cell recruitment in the bronchoalveolar lavage (BALF) were decreased in animals exposed to a low dose of LPS (1 ug) treatment compared with the asthma group. Moderate-dose (10 ug) and high-dose (100 ug) LPS administration showed no differences from controls. Further, low-dose LPS (1 ug) exposure was associated with increased Th1 cytokines, T-bet, Treg cytokine (IL-10, TGF-β), and Foxp3 expression, but decreased Th2 cytokines (IL-4,5,13), GATA3, Th17, and ROR-γt expression compared with the asthma group. Finally, higher numbers of CD4+CD25+Foxp3+Treg cells, and CD4+INF-γ+T cells, and lower CD4+IL-4+T cells and CD4+IL-17+T cells were observed in the low-dose LPS-treated groups compared to controls.ConclusionsOur findings suggest that prior exposure to low doses of LPS may protect from OVA-induced airway hyperresponsiveness (AHR) and histopathologic changes through regulation of the Th1/Th2 and Treg/Th17 balance.

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Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide Exposure Alleviates Asthma in Mice by Regulating Th1/Th2 and Treg/Th17 Balance

Ding

Liu

2018

Med Sci Monit

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“…Given that development of bronchial asthma is reported to be associated with HLA inheritance [11], concomitance of AD, HT, thymoma-associated MG, and possibly bronchial asthma, could be related to common HLA allele or haplotypes. Since autoantigen is presented on the surface of antigen-presenting cells with HLA-class I (cytotoxic effects of CD8+ T-cells) or HLA-class II (effector effects of CD4+ T-cells), common antigen may also be involved in multiple diseases.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune polyglandular syndrome type 2 and autoimmune hepatitis with thymoma-associated myasthenia gravis: case report

et al. 2020

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Background: Autoimmune polyglandular syndrome type 2 (APS-2) is a rare and complex clinical entity, and little is known about its etiology and progression. Case presentation: A 52-year-old woman with autoimmune hepatitis (AIH) and bronchial asthma was diagnosed with APS-2; autoimmune Addison's disease (AD), and Hashimoto's thyroiditis (HT), and she underwent prednisolone (PSL) treatment. Five months later, she presented ptosis and was diagnosed with thymoma-associated myasthenia gravis (MG). Thymectomy and PSL treatment with immuno-suppressants appeared to ameliorate MG, AD, AIH, HT, and bronchial asthma. HLA typing analysis revealed that the patient had susceptible HLA alleles to MG, AIH, and HT in a Japanese population. Conclusions: This case suggests common endocrinological and autoimmune aspects of APS-2 and AIH with thymoma-associated MG, which are considered to be extremely rare complications.

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“…Other study stratified the study group according to age and revealed that DRB1*03, DRB1*04, DRB1*09, and DRB1*15 were associated with asthma in children. Subgroup analysis by ethnicity showed that DRB1*03 and DRB1*15 were associated with asthma in whites, and DRB1*07 and DRB1*14 were associated with asthma in Asians [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of HLA on development of asthma

Mahdi

Al-Hadithi

Raouf

et al. 2018

Annals of Medicine and Surgery

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BackgroundAsthma is a disease characterized by a chronic inflammation of the airways caused by the interaction of genetic susceptibility with environmental factors. Inflammation and remodeling are critical components of asthma. It is shown that many genes are involved in the pathogenesis of asthma.Aim of studyTo identify/compare the association between HLA-DRB1 alleles and development of asthma in a sample of Iraqi Arab Muslims.Patients and methodsA case-control study (forty patients and forty healthy control) was carried out in Medical city Teaching Hospital, Baghdad-Iraq. The study participants were patients with asthma consulted the hospital from September - 2013 to January - 2015. HLA –DRB1genotyping was done using a panel of sequence-specific oligonucleotide probes (SSOP) using HLA-DRB1amplification and hybridization kits (SSO HLA type DRB1 plus and Mastermix for HLA type DRB1 Amp plus kits -Innogenetics-Belgium) using automated method by AutoLipa – 48Innogenetics-Belgum.ResultsThere was an increased frequency of HLADRB1*03:01:01 in control group compared with patients group (P = 0.009, Odds ratio = 0.1228, 95% CI: 0.0254–0.5930). Other allele like HLA-DRB1* 070101was significantly increased in asthmatic patients in compares with control group (P = 0.005, Odds ratio = 6.641, 95% CI: 1.7319–25.4657).ConclusionsHLA alleles have an effect on development asthma in patients with HLA-DRB1*070101 while HLADRB1* 030101 may have a protective effect in Iraqi Arab Muslims individuals against development of asthma.

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Association of HLA-DRB1 Gene Polymorphism with Risk of Asthma: A Meta-Analysis

Cited by 14 publications

References 36 publications

Lipopolysaccharide Exposure Alleviates Asthma in Mice by Regulating Th1/Th2 and Treg/Th17 Balance

Lipopolysaccharide Exposure Alleviates Asthma in Mice by Regulating Th1/Th2 and Treg/Th17 Balance

Autoimmune polyglandular syndrome type 2 and autoimmune hepatitis with thymoma-associated myasthenia gravis: case report

Effect of HLA on development of asthma

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