Association of Human Papillomavirus With Oral Lichen Planus and Oral Leukoplakia: A Meta-analysis

Shang, Qianhui; Peng, Jiakuan; Zhou, Yu; Chen, Qianming; Xu, Hao

doi:10.1016/j.jebdp.2020.101485

Cited by 26 publications

(26 citation statements)

References 54 publications

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“…Oral lichen planus (OLP) and lichenoid mucositis (LM) are immune‐mediated mucosal reactions (Alrashdan et al, 2016 ). Multiple factors were proposed to cause OLP and LM, including autoimmunity, medications, dental restorations, stress, and hepatitis C. OLP/LM have been associated with infectious agents such as hepatitis C and human papillomavirus (Lodi et al, 2010 ; Shang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

New onset and exacerbation of oral lichenoid mucositis following SARS‐CoV‐2 infection or vaccination

2022

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Section: Introductionmentioning

confidence: 99%

New onset and exacerbation of oral lichenoid mucositis following SARS‐CoV‐2 infection or vaccination

2022

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“…It remains unknown whether infection with human papillomavirus (HPV) represents a risk factor for malignant transformation remains unknown. Recent meta-analysis showed association of OLP with HPV but so far no implication for cancer development [ 21 ]. No association of HPV and dysplastic changes in OLP was identified [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation—A Retrospective Study of 271 Patients

Radochová

Ivančaková

Heneberk

et al. 2021

IJERPH

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Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with an unknown etiology rating among oral potentially malignant disorder. The aim of the study was to determine the epidemiological and clinical characteristics of the patients with OLP and rate of malignant transformation. Patients and methods: Data were obtained from the medical records of 271 patients referred to the Oral Medicine Unit at the University Hospital in Hradec Králové diagnosed with oral lichen planus in the period of 2003–2020. The records were retrospectively analyzed. The following clinical data were retrieved from the medical charts: gender, age, systemic diseases, alcohol and tobacco consumption, localization/clinical appearance of lesions, distribution of the lesions, presence of the symptoms, treatment provided and malignant transformation. Results: A total of 271 charts of patients with confirmed diagnosis of OLP were retrospectively analyzed, of whom, 66.4% (180/271) were women and 33.6% (91/271) were men. The mean age of the patients was 56.0 (18.2–85.0) years. The median follow-up of all patients was 15.2 months. Overall, 2 patients (2/271, 0.74%) meeting the above-mentioned criteria for malignant transformation were identified during the follow-up period. Both patients suffered from erosive type OLP and developed squamous cell carcinoma of the tongue. Conclusions: This retrospective study is in concordance with other studies showing the similar profile and clinical features of the patients with OLP. Malignant transformation rate was 0.74%.

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“…OLP is also associated with viral infections, with the frequency of infections ranging from 27 to 65% [90]. Some authors hypothesize the influence of erosive OLP in increasing the risk of HPV infection, although this hypothesis has not been confirmed by subsequent research [91]. In the review Syrjänen et al prevalence of HPV infection in OLP was 5.12%, with genotype 16 most commonly involved [29].…”

Section: Hpv and Oral Potentially Malignant Disorders (Opmds)mentioning

confidence: 99%

The Presence of HPV in Dental Calculus: It’s Role in Pathogenesis of Oral and Cervical Cancer

Widyaputra¹,

Pranata²,

Setiawan³

et al. 2021

Cervical Cancer - A Global Public Health Treatise

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Human papillomavirus (HPV) infection accounts for approximately 5.2% of the worldwide human cancer burden. Molecular epidemiologic evidence clearly indicates that certain types of HPV are the principal cause of both cervical and oral cancers. Major oncoproteins E6 and E7 can inactivate p53 and pRB proteins because it happened genome instability and dysregulation host cell cycles. This virus is an epithelial tropism, vulnerable area mainly at the basal layer and epithelial stem cell, because it still has a high proliferation capacity, so it can support the replication of the virus. Virions bind initially to the glycosaminoglycan (GAG) chains of heparan sulphate proteoglycan (HSPG). More than 99% cervical cancer arise at the cervical transformation zone. In oral cavity, exposed areas of the basal layer will be very susceptible to HPV infection. The HPV presence in the oral area is considered as one of the etiologics of oral cancer in those who do not have bad habits such as smoking, betel chewing, or poor oral hygiene. Our study successfully identified HPV type 58 in dental calculus. Dental calculus, calcified oral plaque biofilm, has been shown to be an abundant, nearly ubiquitous, and long-term reservoir of the ancient oral microbiome, including bacteria, archaea, eukaryote, and viruses. During biomineral maturation process, several biological contents around the oral region should be trapped, including the exfoliated virus contained cells. Dental calculus is a promising source of HPV and carcinogens molecules in the oral cavity and could be used as a biomarker for early detection.

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Association of Human Papillomavirus With Oral Lichen Planus and Oral Leukoplakia: A Meta-analysis

Cited by 26 publications

References 54 publications

New onset and exacerbation of oral lichenoid mucositis following SARS‐CoV‐2 infection or vaccination

New onset and exacerbation of oral lichenoid mucositis following SARS‐CoV‐2 infection or vaccination

The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation—A Retrospective Study of 271 Patients

The Presence of HPV in Dental Calculus: It’s Role in Pathogenesis of Oral and Cervical Cancer

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