Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring

Maher, Gillian M.; O’Keeffe, Gerard W.; Kearney, Patricia M.; Kenny, Louise C.; Dinan, Timothy G.; Mattsson, Molly; Khashan, Ali S.

doi:10.1001/jamapsychiatry.2018.0854

Cited by 204 publications

(169 citation statements)

References 107 publications

(395 reference statements)

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“…[Mandl, Tronick, Brennan, Alpert, & Homer, 1999]. On the other hand, chronic maternal noncommunicable diseases (NCDs) such as diabetes or hypertension during pregnancy have been associated with having ASD in the offspring [Maher et al, 2018;Xu, Jing, Bowers, Liu, & Bao, 2014].…”

Section: Factors Contributing To Depression Among Mothers Of Childrenmentioning

confidence: 99%

Burden of major depressive disorder and quality of life among mothers of children with autism spectrum disorder in urban bangladesh

Naheed

Islam

Hossain³

et al. 2019

Autism Research

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This cross‐sectional study examined the burden of depression and quality of life (QoL) among mothers of children with autism spectrum disorder (ASD) attending six schools offering special educational services for children with ASD in urban Dhaka, Bangladesh. All consenting mothers were 18 years of age and older and met criteria for major depressive disorder (MDD) on the Structured Interview for DSM‐V‐TR Research Version‐non patient edition administered by trained raters. QoL was assessed by the EuroQol five‐dimensional standardized questionnaire. MDD was diagnosed in 45% of mothers and was proportionally higher among those who did not work outside the home, had no childcare support at home, expressed low level of satisfaction with the quality of providers when they had sought care for their children with ASD, and reported being recipient of negative attitudes from neighbors toward their children with ASD. QoL was negatively associated with MDD, mothers' illness, and low satisfaction with the health care providers for children with ASD, as well as experiencing a negative attitude by neighbors toward their children. QoL was positively associated with the reported family monthly income and improvement of the children with ASD on school attendance. The prevalence of MDD among mothers of children with ASD was high and associated with poor QoL. Integrating mental health services and supports for mothers in the ASD care of children is likely to address the high burden of depression they face, and improve their overall quality of life. Autism Res 2020, 13: 284–297. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary The levels of depression were assessed among mothers of children with autism spectrum disorder (ASD) attending six schools offering special educational services for children with ASD in urban Dhaka, Bangladesh. Almost one in two mothers was found to have major depression. The quality of life of these mothers was generally poor. Integrating mental health services for mothers with ASD care in children is likely to address the burden of depression among the mothers of children with ASD and improve overall quality of life.

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Section: Factors Contributing To Depression Among Mothers Of Childrenmentioning

confidence: 99%

Burden of major depressive disorder and quality of life among mothers of children with autism spectrum disorder in urban bangladesh

Naheed

Islam

Hossain³

et al. 2019

Autism Research

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“…Preeclampsia (PE) is a pregnancy-induced hypertensive disorder marked by a new-onset hypertension and one or more maternal manifestations including proteinuria, maternal organ dysfunction, or uteroplacental dysfunction presenting after 20 gestational weeks [8]. This condition is the second main cause of maternal death worldwide and one of the leading causes of adverse fetal outcomes, such as low birth weight and prematurity [9][10][11][12]. The widely used clinical subclassification for assessing the severity of preeclampsia includes early-and late-onset PE: diagnosed at their occurrence before and after 34 weeks of gestation, respectively [8].…”

Section: Introductionmentioning

confidence: 99%

Maternal Exposure to Ambient Air Pollution and Risk of Preeclampsia: A Population-Based Cohort Study in Scania, Sweden

Mandakh

Rittner

Flanagan

et al. 2020

IJERPH

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The aim of this study was to investigate the risk of developing preeclampsia (PE) associated with gestational exposure to ambient air pollutants in southern Sweden, a low-exposure area. We used a cohort of 43,688 singleton pregnancies and monthly mean exposure levels of black carbon (BC), local and total particulate matter (PM 2.5 and PM 10 ), and NO X at the maternal residential address estimated by Gaussian dispersion modeling from 2000 to 2009. Analyses were conducted using binary logistic regression. A subtype analysis for small-for-gestational age (SGA) was performed. All analyses were adjusted for obstetrical risk factors and socioeconomic predictors. There were 1286 (2.9%) PE cases in the analysis. An adjusted odds ratio (AOR) of 1.35 with a 95% confidence interval (CI) of 1.11-1.63 was found when comparing the lowest quartile of BC exposure to the highest quartile in the third trimester The AOR for PE associated with each 5 µg/m 3 increase in locally emitted PM 2.5 was 2.74 (95% CI: 1.68, 4.47) in the entire pregnancy. Similar patterns were observed for each 5 µg/m 3 increment in locally emitted PM 10 . In pregnancies complicated by PE with SGA, the corresponding AOR for linear increases in BC was 3.48 (95% CI: 1.67, 7.27). In this low-level setting, maternal exposure to ambient air pollution during gestation was associated with the risk of developing PE. The associations seemed more pronounced in pregnancies with SGA complications, a finding that should be investigated further.

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“…eclampsia and HELLP syndromehemolysis, elevated liver enzymes, and low platelets) (Butalia et al, 2018;Magee et al, 2018). Occurring in approximately 10-15% of pregnancies (Umesawa & Kobashi, 2017), HDP alter in-utero fetal growth conditions and are associated with elevated risk for preterm birth and increased long-term vascular, psychiatric, and neurodevelopmental outcomes in infants (Maher et al, 2018;Regitz-Zagrosek et al, 2011). HDP are also associated with adverse short-and long-term maternal outcomes, including increased risk of maternal morbidity and death, and a higher likelihood of future medical (i.e.…”

mentioning

confidence: 99%

Depressed mood and anxiety as risk factors for hypertensive disorders of pregnancy: a systematic review and meta-analysis

et al. 2020

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Background Psychosocial factors have been implicated as both a cause and consequence of hypertension in the general population but are less understood in relation to hypertensive disorders of pregnancy (HDP). The aims of this review were to (1) synthesize the existing literature examining associations between depression and/or anxiety in pregnancy and HDP and (2) assess if depression and/or anxiety in early pregnancy was a risk factor for HDP. Methods A comprehensive search of Medline, Embase, CINAHL, and PsycINFO was conducted from inception to March 2020 using terms related to ‘pregnancy’, ‘anxiety’, ‘depression’, and ‘hypertensive disorders’. English-language cohort and case-control studies were included if they reported: (a) the presence or absence of clinically significant symptoms of depression/anxiety, or a medical record diagnosis of depression or an anxiety disorder in pregnancy; (b) diagnosis of HDP; and/or (c) data comparing the depressed/anxious group to the non-depressed/anxious group on HDP. Data related to depression/anxiety, HDP, study characteristics, and aspects related to study quality were extracted independently by two reviewers. Random-effects meta-analyses of estimated pooled relative risks (RRs) were conducted for depression/anxiety in pregnancy and HDP. Results In total, 6291 citations were retrieved, and 44 studies were included across 61.2 million pregnancies. Depression and/or anxiety were associated with HDP [RR = 1.39; 95% confidence interval (CI) 1.25–1.54]. Conclusions When measurement of anxiety or depression preceded diagnosis of hypertension, the association remained (RR = 1.27; 95% CI 1.07–1.50). Women experiencing depression or anxiety in pregnancy have an increased prevalence of HDP compared to their non-depressed or non-anxious counterparts.

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Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring

Abstract: Exposure to HDP may be associated with an increase in the risk of ASD and ADHD. These findings highlight the need for greater pediatric surveillance of infants exposed to HDP to allow early intervention that may improve neurodevelopmental outcome.

Cited by 204 publications

References 107 publications

Burden of major depressive disorder and quality of life among mothers of children with autism spectrum disorder in urban bangladesh

Burden of major depressive disorder and quality of life among mothers of children with autism spectrum disorder in urban bangladesh

Maternal Exposure to Ambient Air Pollution and Risk of Preeclampsia: A Population-Based Cohort Study in Scania, Sweden

Depressed mood and anxiety as risk factors for hypertensive disorders of pregnancy: a systematic review and meta-analysis

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