Association of hypoadiponectinemia in men with early onset of coronary heart disease and multiple coronary artery stenoses

Hashimoto, Naotake; Kanda, Junji; Nakamura, Tomonori; Horie, Atsuya; Kurosawa, Hiroko; Hashimoto, Toru; Sato, Kazutoshi; Kushida, Syunichi; Suzuki, Mitsuaki; Yano, Shingo; Iwai, Rie; Takahashi, Hidenori; Yoshida, Shouji

doi:10.1016/j.metabol.2006.08.005

Cited by 56 publications

(39 citation statements)

References 26 publications

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“…In other studies, hypoadiponectinemia was observed to correlate with the prevalence or extent of CAD (11,12) and to serve as a risk factor for coronary heart disease (13,14). The aim of the present study, therefore, was to explore the relationship between serum adiponectin concentrations and the presence of the metabolic syndrome among patients with CAD.…”

Section: Adiponectin An Adipokine Now Recognized As a Key Regulator mentioning

confidence: 83%

“…This adipokine is reported to improve hepatic insulin sensitivity, to up-regulate adenosine monophosphate activated protein kinase (AMPK) activity in liver and skeletal muscle, and to ameliorate vascular inflammation (7,8,13). Serum adiponectin concentrations are decreased in patients with metabolic syndrome (9,10), and a low serum adiponectin value is independently associated with both metabolic syndrome and CAD (21).…”

Section: T a B L E 6 Mu L T I V A R I A T E S T E P Wi S E L I N E mentioning

confidence: 99%

“…CAD and has been shown to be a risk factor for cardiovascular events (11,13,14 (8). In several studies, serum adiponectin concentrations were found to correlate positively with HDLcholesterol concentrations and negatively with TG concentrations (10,13,32,33 …”

Section: Adiponectin Is Proposed To Exert Direct Anti-atheroscleroticmentioning

confidence: 99%

“…In several studies, serum adiponectin concentrations were found to correlate positively with HDLcholesterol concentrations and negatively with TG concentrations (10,13,32,33 …”

Section: Adiponectin Is Proposed To Exert Direct Anti-atheroscleroticmentioning

confidence: 99%

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Fasting Adiponectin is Inversely Correlated with Metabolic Syndrome in Patients with Coronary Artery Disease

Wang

Lee²,

Lee³

et al. 2010

Intern. Med.

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Objective Hypoadiponectemia was observed to correlate with the prevalence or extent of coronary artery disease (CAD) r=0.267; p=0.008) but were negatively correlated with triglyceride concentration (TG; p=0.013). Multivariate forward stepwise linear regression analysis of the significant variables revealed that HDL-cholesterol concentration (R square=0.071, p=0.008) and age (R square=0.039, p=0.044)

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Section: Adiponectin An Adipokine Now Recognized As a Key Regulator mentioning

confidence: 83%

Section: T a B L E 6 Mu L T I V A R I A T E S T E P Wi S E L I N E mentioning

confidence: 99%

Section: Adiponectin Is Proposed To Exert Direct Anti-atheroscleroticmentioning

confidence: 99%

“…In several studies, serum adiponectin concentrations were found to correlate positively with HDLcholesterol concentrations and negatively with TG concentrations (10,13,32,33 …”

Section: Adiponectin Is Proposed To Exert Direct Anti-atheroscleroticmentioning

confidence: 99%

See 2 more Smart Citations

Fasting Adiponectin is Inversely Correlated with Metabolic Syndrome in Patients with Coronary Artery Disease

Wang

Lee²,

Lee³

et al. 2010

Intern. Med.

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show abstract

“…6 In young survivors (o60 years of age) following a first myocardial infarction, however, a low plasma adiponectin level was associated with recurrent infarction. 7 Indeed, hypoadiponectinemia has usually been recognized as a risk factor for CAD [8][9][10] and the adiponectin level was linked to the severity of heart failure in our previous study. 11 Taken together, it seems that the plasma adiponectin level may influence cardiovascular or cerebrovascular events but not decisively, because the adiponectin level varies in relation to gender, race and the presence or absence of lifestyle-related disease.…”

Section: Introductionmentioning

confidence: 82%

Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels

et al. 2012

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As the plasma level of adiponectin is related to metabolic syndrome and cardiovascular events, a low plasma adiponectin level may either cause or trigger cardiovascular disorders. The purpose of this study was to determine whether a low adiponectin level contributes to cardiovascular events, and to investigate the factors influencing adiponectin in the Japanese Arita-cho cohort study.We followed about 2000 subjects in Arita-cho, Saga, Japan as a cohort study, and we enrolled 637 subjects (205 men; 65.1 ± 8.3 years old) who participated in annual health checks from 2005 to 2008 and underwent measurement of the plasma adiponectin level and an oral glucose tolerance test. We monitored the incidence of cardiovascular or cerebrovascular events in these subjects until the end of 2010, discontinuing follow-up at 3 years after the start of enrollment. Subjects with low plasma adiponectin levels (o10.5 ng ml À1 ) had a higher incidence of newly diagnosed cardiovascular diseases such as acute heart failure or acute myocardial infarction than those with high plasma adiponectin levels (X10.5 ng ml À1 ) over an average of 2.95 years of follow-up. Multivariate analysis showed that the adiponectin level was predicted by the following parameters in all subjects: age (b ¼ 0.16), male gender (b ¼ À0.267), homeostasis model assessment of insulin resistance (b ¼ À0.140) and the plasma levels of high-density lipoprotein cholesterol (b ¼ 0.104), uric acid (b ¼ À0.13), triglycerides (b ¼ À0.169) and brain natriuretic peptide (b ¼ 0.151). The difference in plasma glucose before and 120 min after the intake of a 75-g glucose load did not influence the plasma adiponectin level. The plasma adiponectin level is useful for predicting cardiovascular events, and is a measure of the risk of lifestyle-related diseases.

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Adiponectin resistance in skeletal muscle: pathophysiological implications in chronic heart failure

Sente

Berendoncks

Hoymans

et al. 2015

J cachexia sarcopenia muscle

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Skeletal muscle wasting is a common complication of chronic heart failure (CHF) and linked to poor patient prognosis. In recent years, adiponectin was postulated to be centrally involved in CHF‐associated metabolic failure and muscle wasting. This review discusses current knowledge on the role of adiponectin in CHF. Particular emphasis will be given to the complex interaction mechanisms and the intracellular pathways underlying adiponectin resistance in skeletal muscle of CHF patients. In this review, we propose that the resistance process is multifactorial, integrating abnormalities emanating from insulin signalling, mitochondrial biogenesis, and ceramide metabolism.

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Association of hypoadiponectinemia in men with early onset of coronary heart disease and multiple coronary artery stenoses

Cited by 56 publications

References 26 publications

Fasting Adiponectin is Inversely Correlated with Metabolic Syndrome in Patients with Coronary Artery Disease

Fasting Adiponectin is Inversely Correlated with Metabolic Syndrome in Patients with Coronary Artery Disease

Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels

Adiponectin resistance in skeletal muscle: pathophysiological implications in chronic heart failure

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