Fasting Adiponectin is Inversely Correlated with Metabolic Syndrome in Patients with Coronary Artery Disease

Wang, Ji-Hung; Lee, Chung‐Jen; Lee, Chia‐Chi; Chen, Yu‐Chih; Lee, Ru‐Ping; Hsu, Bang‐Gee

doi:10.2169/internalmedicine.49.3093

Cited by 12 publications

(8 citation statements)

References 43 publications

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“…Adiponectin is widely known to promote anti-inflammatory effects such as inhibition of NF-κB, TNF-α, IL-6 and IFN-γ, while increasing levels of IL-10 and IL1RA [16]. These effects are believed to confer protection against chronic disease conditions like atherosclerosis [17] and the metabolic syndrome [18]. To some extent, these protective effects are due to the ability of adiponectin to phosphorylate AMPK via ADRs [19,20].…”

Section: Discussionmentioning

confidence: 99%

Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death

Thundyil

Tang

Okun

et al. 2010

Exp & Trans Stroke Med

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Background-Adiponectin is a hormone produced in and released from adipose cells, which has been shown to have anti-diabetic and anti-inflammatory actions in peripheral cells. Two cell surface adiponectin receptors (ADRs) mediate the majority of the known biological actions of adiponectin. Thus far, ADR expression in the brain has been demonstrated in the arcuate and the paraventricular nucleus of hypothalamus, where its activation affects food intake. Recent findings suggest that levels of circulating adiponectin increase after an ischemic stroke, but the role of adiponectin receptor activation in stroke pathogenesis and its functional outcome is unclear.Methods-Ischemic stroke was induced in C57BL/6 mice by middle cerebral artery occlusion (MCAO) for 1 h, followed by reperfusion. Primary cortical neuronal cultures were established from individual embryonic neocortex. For glucose deprivation (GD), cultured neurons were incubated in glucose-free Locke's medium for 6, 12 or 24 h. For combined oxygen and glucose deprivation (OGD), neurons were incubated in glucose-free Locke's medium in an oxygen-free chamber with 95% N2/5% CO2 atmosphere for either 3, 6, 9, 12 or 24 h. Primary neurons and brain tissues were analysed for Adiponectin and ADRs using reverse transcriptase polymerase chain reaction (RT-PCR), immunoblot and immunochemistry methods.Results-Cortical neurons express ADR1 and ADR2, and that the levels of ADR1 are increased in neurons in response to in vitro or in vivo ischemic conditions. Neurons treated with either globular or trimeric adiponectin exhibited increased vulnerability to oxygen and glucose deprivation which was associated with increased activation of a pro-apoptotic signaling cascade involving p38 mitogen-activated protein kinase (p38MAPK) and AMP-activated protein kinase (AMPK).Conclusions-This study reveals a novel pathogenic role for adiponectin and adiponectin receptor activation in ischemic stroke. We show that cortical neurons express ADRs and reveal a pro-apoptotic role for ADR1 activation in neurons, which may render them vulnerable to ischemic death.

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Section: Discussionmentioning

confidence: 99%

Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death

Thundyil

Tang

Okun

et al. 2010

Exp & Trans Stroke Med

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“…In addition, adiponectin strongly suppressed the proliferation and migration of vascular smooth muscle cells that is atherogenic [10,11]. In fact, it has been reported that higher adiponectin levels are closely associated with fewer MS components [12,13]. However, there have been a very limited number of clinical studies that examined the association between serum osteocalcin and MS in humans.…”

Section: Introductionmentioning

confidence: 99%

The association between serum osteocalcin levels and metabolic syndrome in Koreans

et al. 2010

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“…In humans, decreased plasma adiponectin levels have been demonstrated in patients with obesity, diabetes, and CHD [43][44][45] . Moreover, the degree of hypoadiponectinemia has been reported to be correlated with the degree of insulin resistance 46,47 , and hypoadiponectinemia has been shown to be closely associated with the clinical phenotype of metabolic syndrome 48,49 . Adiponectin served as an antiinflammatory molecule for vascular walls as well as adipose tissue 50 , hypoadiponectinemia was observed in obesity-linked diseases 43,51 .…”

Section: Table 4: Correlation Of Serum Adiponectin and Free Fatty Acimentioning

confidence: 99%

Untitled

2017

IJPSR

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Background: Metabolic syndrome (MetS) is a cluster of diseases, including hypertension, obesity, dyslipidemia, and hyperglycemia. We therefore aimed to estimate MetS prevalence and to determine risk factors for MetS. Methods: In the present study, we recruited 209 adult Tunisian MetS patients (57 males and 152 females, mean age 58.9±10.7 years) matched by gender and ethnic origin to 193 healthy individuals (31males and 162 females, mean age 50.3±10.6 years). All subjects underwent anthropometric and biochemical examinations. Results: Interestingly, the prevalence of MetS was 21.89% in males and 78.1% in females. Notable increase in the dyslipidemia (64.1%), hypertension (77%), and obesity (83.73%) in patients with MetS were seen. In addition, insulin resistance, hyperglycemia, abnormal lipid profiles, increased free fatty acids, and lower serum adiponectin concentrations were all associated with MetS. Conclusion: We suggest that the MetS is highly prevalent among patients group than healthy subjects. Modification of lifestyle factors, even later in life, has considerable potential for primary prevention of the MetS.

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Fasting Adiponectin is Inversely Correlated with Metabolic Syndrome in Patients with Coronary Artery Disease

Cited by 12 publications

References 43 publications

Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death

Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death

The association between serum osteocalcin levels and metabolic syndrome in Koreans

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