Association of Collagen Type I α1 (COLIA1) Sp1 Polymorphism with Osteoporotic Fracture in Caucasian Post-menopausal Women: a Meta-analysis

Effects of COLIA1 polymorphisms and haplotypes on perimenopausal bone mass, postmenopausal bone loss and fracture risk

“…Most studies, including a metaanalysis, have found that the T allele of the +1245GT polymorphism is associated with reduced BMD and increased risk of fractures in elderly populations [6,8,[25][26][27][28][29][30]. However, these effects are generally not seen in younger populations [31][32][33][34].…”

The IL6 gene polymorphism −634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women

“…It has become apparent that altered activity of several genes, including those encoding vitamin D receptor (Morrison et al, 1994), estrogen receptor-α (Albagha et al, 2005), IL-6 (Czerny et al, 2010), collagen type Iα1 (Ji et al, 2009), and lipoprotein receptor-related protein 5 (Riancho et al, 2011), play a role in the etiology of osteoporosis. However, most of the studies performed to date have focused on postmenopausal women, and little is known about whether polymorphisms that affect bone metabolism are associated with changes in bone mineral density (BMD) in earlier life.…”

Sp1 binding site polymorphism of a collagen gene (rs 1800012) in womenaged 45 and over and its association with bone density

“…A study in Turkey indicated that bone density in the individuals with genotype Ss was lower compared to those with genotype SS (41), consistent with the present study. Some (27). Since collagen I has numerous polymorphisms, it is recommended that the association of other collagen I polymorphisms with bone density be examined to achieve a complete haplotype.…”