Association ofFTOPolymorphisms with Early Age of Obesity in Obese Italian Subjects

Sentinelli, Federica; Incani, Michela; Coccia, Federica; Capoccia, Danila; Cambuli, Valentina M.; Romeo, Stefano; Cossu, Efisio; Cavallo, Maria Gisella; Leonetti, Frida; Baroni, Marco Giorgio

doi:10.1155/2012/872176

Cited by 42 publications

(75 citation statements)

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“…Our findings are in concordance with previous studies reporting the association of the FTO A allele with increased BMI and that the frequency of the A allele in our study was similar to that observed in other populations ranging from 45 to 48% [4, 20]. This may suggest that the effects of environmental factors on obesity in Kuwait are larger than genetic factors.…”

Section: Discussionsupporting

confidence: 93%

“…This is consistent with recent findings showing that different variants within the FTO gene are associated with different classes of obesity [6]. Moreover, a study by Sentinelli et al [20] showed an association between the common FTO rs9939609 polymorphism with BMI in an Italian population; however, a stronger association was observed with another polymorphism, rs9930506, within the FTO gene suggesting the impact of other polymorphisms on BMI. This also supports findings that the impact of FTO on obesity is population-dependent [20, 22].…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, a study by Sentinelli et al [20] showed an association between the common FTO rs9939609 polymorphism with BMI in an Italian population; however, a stronger association was observed with another polymorphism, rs9930506, within the FTO gene suggesting the impact of other polymorphisms on BMI. This also supports findings that the impact of FTO on obesity is population-dependent [20, 22]. These findings may explain our borderline association of the rs9939609 with the BMI; however, this needs to be replicated further in other cohorts in the population.…”

Section: Discussionmentioning

confidence: 99%

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Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

et al. 2018

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Objective: To investigate the effect of the common fat mass and obesity-associated (FTO) gene polymorphism rs9939609 on body mass index (BMI) in one of the most obese populations worldwide. Subjects and Methods: Genotypic data for FTO rs9939609 were available for 1,034 unrelated Kuwaiti adults obtained from Kuwait’s Dasman Diabetes Institute and Kuwait University. The association between the FTO polymorphism with BMI as continuous and categorical (normal BMI [< 25] vs. overweight/obese [> 25]) variables was analyzed using both linear and logistic regression models, respectively, with the assumption of both dominant and additive genetic models performed using the SNPassoc package from R statistics. Results: The A allele was associated with increased BMI (β = 1.21; 95% CI = 0.16–2.26; p = 0.023). In concordance, the categorical BMI (normal vs. overweight/obese) also showed a significant association between the A allele and overweight/obesity (OR = 1.47; 95% CI = 1.01–2.12; p = 0.041). However, no association between the FTO variant was observed with cardiometabolic traits. Conclusion: We observed an association between the common FTO rs9939609 polymorphism and increased BMI (overweight/obesity) in Kuwaiti adults, which is consistent with previous research in other populations. Our findings encourage further investigation of genetic variants to elucidate the mechanisms involved in the development of obesity in such an obesogenic population.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

et al. 2018

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“…Some meta-analysis studies have found a relationship among FTO and specific cancer types, including PCa [16,21–23]. All these findings are related to a cluster of single-nucleotide SNPs (SNPs) in the FTO gene first intron which is inherited in linkage disequilibrium (LD) [9,15,18,24,25], and includes among others the rs9930506 and rs9939609 SNPs as reported by Loos et al [26]. In this GWAS study done by Loos’ group with an admixed American population which included participants from Colombia, Mexico and PR, they found that the above mentioned FTO SNPs among others, are related in a statistically significant manner to an increased BMI [26].…”

Section: Introductionmentioning

confidence: 99%

“…In FTO rs9930506 , the single nucleotide transition of an adenine nucleotide to a guanine nucleotide has been reported to be significantly associated to BMI, particularly when the rare “G” allele is present in the homozygous form [25,27]. In addition, in FTO rs9939609 , the single nucleotide transversion of a thymine nucleotide to an adenine nucleotide has been associated with both BMI and type-2 diabetes, in either the heterozygous or the homozygous forms of the mutated “ A ” allele [25,28].…”

Section: Introductionmentioning

confidence: 99%

Impact of FTO SNPs rs9930506 and rs9939609 in Prostate Cancer Severity in a Cohort of Puerto Rican Men

Salgado-Montilla

Rodríguez-Cabán

Sánchez-García

et al. 2017

Can Res

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Background Obesity is prevalent in PR and has been associated with prostate cancer (PCa) mortality and aggressiveness. Polymorphisms (SNPs) rs9930506 and rs9939609 in the FTO gene have been associated with both obesity and PCa. The aim of this work was to ascertain whether the presence of these SNPs is associated with PCa risk and severity in a cohort of Puerto Rican men. Methods and findings The study population consisted of 513 Puerto Rican men age ranging from 40–79 years old who underwent radical prostatectomy (RP) as the first treatment for PCa and 128 healthy Puerto Rican men age ranging from 40–79 years old. Genomic DNA (gDNA) was extracted and SNPs were determined by Real-Time PCR. PCa severity was defined based on RP stage and Gleason Score. The relationship of FTO SNPs with demographic, clinical characteristics, PCa status and PCa severity were assessed. Logistic regression models with a 95% confidence interval (CI) determined SNPs interaction with PCa risk and severity odds ratio (ORs). Results and discussion BMI, age and PSA were considered as confounders. Hardy-Weinberg equilibrium was present for both SNPs. The heterozygous forms (A/G; T/A) were the most prevalent genotypes and the frequency of alleles and genotypes for both SNPs agreed with those published in 1000 genomes. Results suggest an inverse association between the mutated rs9939609 and the risk of having PCa (OR: 0.53, 95% CI: 0.31–0.92) and a positive association with overweight (OR: 1.05, 95% CI: 0.68–1.62). Importantly, among the cases that were overweight, those with mutated rs9939609 had a greater chance of high severity PCa (OR: 1.39, 95% CI: 0.84–2.32) although these results were not statistical significant upon adjustment. Limitations of the study were the relatively small cohort and lack of access to the weight history of all our subjects. Conclusion Results offer a research line to be followed with an expanded number of subjects that may provide a better statistical significance, to unravel the high mortality rate in this population.

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Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study

et al. 2021

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Aims Nutritional and lifestyle interventions can contribute to prevent and treat obesity and its complications; however, genetic background may influence the success of a therapy. The aim of this pilot study is to evaluate the effects of the interaction between nutrigenetic variants and nutritional intervention, as well as the changes in clinical parameters and the adherence to Mediterranean diet (MedDiet) and to physical activity, of 18 overweight or obese subjects affected by T2D or dysglycemia included in a nutritional program. Methods The subjects’ clinical parameters as well as their PREDIMED score and physical activity levels were recorded and compared at baseline, at 6 months and at the end of the intervention. Rs9939609 in FTO, rs17782313 near MC4R, rs326 in LPL, rs16147 in NPY, rs2943641 near IRS-1 were genotyped. Results The subjects carrying the A allele in FTO lost less weight (p = 0.022) and had a lower BMI decrease from baseline to 12 months (p-interaction = 0.047) than TT carriers. In addition, there was a significant PREDIMED score modification over time, according to genotypes for FTO rs9939609 (p = 0.025) and NPY rs16147 (p = 0.039), respectively. Conclusions These preliminary findings show a significant interaction between genetic variants and the PREDIMED score, suggesting that individuals carrying the FTO variant may lose less weight than non-carriers through diet/lifestyle intervention.

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Association ofFTOPolymorphisms with Early Age of Obesity in Obese Italian Subjects

Cited by 42 publications

References 25 publications

Association of <b><i>FTO</i></b> rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

Association of <b><i>FTO</i></b> rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

Impact of FTO SNPs rs9930506 and rs9939609 in Prostate Cancer Severity in a Cohort of Puerto Rican Men

Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study

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