Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study

Franzago, Marica; Nicola, Marta Di; Fraticelli, Federica; Marchioni, Michele; Stuppia, Liborio; Vitacolonna, Ester

doi:10.1007/s00592-021-01787-7

Cited by 15 publications

(4 citation statements)

References 77 publications

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Section: Epigenetic Effects Of Supplements In Pregnancymentioning

confidence: 99%

“…Vähämiko et al were the first to study how probiotic supplements modified DNA methylation throughout pregnancy in promoters for obesity-related genes in both mothers and their offspring [69]. In particular, the authors showed that probiotic supplementation during pregnancy may be able to modify the DNA methylation level in the promoter of women's FTO gene, that is, the gene most strongly associated with obesity, body mass index, and T2D in several studies [70,71]. In addition, Vähämiko et al found hypomethylation both in the promoter for insulin-like growth factor-binding protein-1 (IGFBP1) and for MSRA (methionine sulfoxde reductase A) In addition, Vähämiko et al found hypomethylation both in the promoter for insulinlike growth factor-binding protein-1 (IGFBP1) and for MSRA (methionine sulfoxde reductase A) in both mothers and their offspring from the group that was administered probiotics.…”

Section: Epigenetic Effects Of Supplements In Pregnancymentioning

confidence: 99%

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Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

et al. 2022

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There is growing interest in the potential role of different stereoisomers of inositol or their combination as well as probiotics supplementation in healthy glucose metabolism during pregnancy and in promoting offspring health. The aim of this review is to clarify the effects of several inositol and probiotics-based supplements in the prevention and treatment of gestational diabetes (GDM). Moreover, we will discuss the epigenetic aspects and their short- and long-term effects in response to probiotic intervention as well as the possible implications of these findings in guiding appropriate supplementation regimens in pregnancy.

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Section: Epigenetic Effects Of Supplements In Pregnancymentioning

confidence: 99%

Section: Epigenetic Effects Of Supplements In Pregnancymentioning

confidence: 99%

Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

et al. 2022

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“…The group-based intervention was crucial to involve the participants in improving their lifestyle. This educational and nutritional program included three main goals to achieve, as previously described [29]: (i) improve the composition of meals, prioritising vegetables as well as whole foods and limiting highly processed foods; (ii) weight loss of at least 7-10%; (iii) plan at least 150 minutes a week of moderate intensity physical activity [25][26][27][28]30].…”

Section: Educational and Nutritional Interventionmentioning

confidence: 99%

Genetic Variants in CD36 Involved in Fat Taste Perception: Association with Anthropometric and Clinical Parameters in Overweight and Obese Subjects Affected by Type 2 Diabetes or Dysglycemia—A Pilot Study

Franzago,

Borrelli,

Di Nicola

et al. 2023

Nutrients

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Obesity and overweight represent a growing health problem worldwide. Genes regulating the intake and metabolism of different nutrients can positively or negatively influence the efficacy of nutritional interventions against obesity and its complications. The aim of this study was to assess changes in anthropometric and clinical parameters and the adherence to a Mediterranean diet (MedDiet) over time in relation to nutrigenetic variants in overweight or obese subjects affected by Type 2 Diabetes (T2D) or dysglycemia, who were included in a nutritional program. A total of 23 subjects were included in this study. Clinical parameters, physical activity levels, and the adherence to a MedDiet were evaluated at baseline, at 6 (T6), and at 12 months (T12) during and after a diet/lifestyle intervention. In a single blood sample from each subject, rs1984112 (A>G) and rs1761667 (G>A) in CD36; rs7950226 (G>A) in BMAL1; and rs1801260 (A>G), rs4864548 (A>G), and rs3736544 (G>A) in CLOCK were genotyped with Real-Time PCR. Significant associations were observed between CD36 rs1761667 and weight (p = 0.025), hip circumference (p = 0.042), triglycerides (p = 0.047), and HbA1c (p = 0.012) at baseline. Moreover, the genotype AA in CD36 rs1761667 was significantly associated with a lower BMI when compared to G carriers at baseline, at T6, and also at T12. In addition, subjects with the AA genotype at CD36 rs1984112 had significantly lower levels of HbA1c (p = 0.027) than the GG and AG genotypes at baseline. These results show that variants in CD36 can have an impact on anthropometric and clinical parameters in overweight or obese subjects affected by T2D or dysglycemia, and that it might influence the success of the diet/lifestyle intervention.

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“…Candidates that might modify the effect of water intake on adiposity include single-nucleotide polymorphisms (SNPs) in obesity-associated genes including, representatively SNPs in the fat mass and obesity-associated gene (FTO) (rs9939609, T>A) [6][7][8], near the melanocortin 4 receptor gene (MC4R) (rs17782313, T>C) [9][10][11], in brain-derived neurotrophic factor gene (BDNF) (rs6265, C>T) [12,13]. Previous studies have shown that these genetic variations are implicated in obesity risk by modulating energy intake and energy expenditure [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Water intake and obesity: By amount, timing, and perceived temperature of drinking water

Khil,

Chen,

Lee

et al. 2024

PLoS ONE

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Water intake has been suggested to be associated with weight control, but evidence for optimal water intake in terms of amount, timing, and temperature is sparse. Additionally, genetic predisposition to obesity, which affects satiety and energy expenditure, might interact with water intake in regulating individual adiposity risk. We conducted a cross-sectional study recruiting 172 Korean adults. Information on water intake and lifestyle factors was collected through self-reported questionnaires, and height, weight, and waist circumference (WC) were measured by researchers. The oral buccal swab was performed for genotyping of FTO rs9939609, MC4R rs17782313, BDNF rs6265 and genetic risk of obesity was calculated. Linear regression was performed to estimate mean difference in body mass index (BMI) and WC by water intake and its 95% confidence interval (95% CI). As a sensitivity analysis, logistic regression was performed to estimate odds ratio (OR) of obesity/overweight (BMI of ≥23kg/m2; WC of ≥90cm for men and of ≥80cm for women) and its 95% CI. Drinking >1L/day was significantly associated with higher BMI (mean difference: 0.90, 95% CI 0.09, 1.72) and WC (mean difference: 3.01, 95% CI 0.62, 5.41) compared with drinking ≤1L/day. Independent of total water intake, drinking before bedtime was significantly associated with lower BMI (mean difference: -0.98, 95% CI -1.91, -0.05). The results remained consistent when continuous BMI and WC were analyzed as categorical outcomes. By perceived temperature, drinking >1L/day of cold water was associated with higher BMI and WC compared with drinking ≤1L/day of water at room-temperature. By genetic predisposition to obesity, a positive association between water intake and WC was confined to participants with low genetic risk of obesity (P interaction = 0.04). In conclusion, amount, timing, and perceived temperature of water intake may be associated with adiposity risk and the associations might vary according to genetic predisposition to obesity.

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Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study

Cited by 15 publications

References 77 publications

Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

Genetic Variants in CD36 Involved in Fat Taste Perception: Association with Anthropometric and Clinical Parameters in Overweight and Obese Subjects Affected by Type 2 Diabetes or Dysglycemia—A Pilot Study

Water intake and obesity: By amount, timing, and perceived temperature of drinking water

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