Association of MNS16A VNTR and hTERT rs2736098: G&gt;A polymorphisms with susceptibility to diffuse large B-cell lymphoma

Essa, Enas Said; Alagizy, Hagar A.

doi:10.5301/tj.5000653

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…The polymorphic number of MNS16A tandem repeats was reported to be associated with the risk of several malignancies, including lung24,47 or colorectal and prostate cancer,38,39 malignant gliomas,40,41 as well as Alzheimer’s disease 48. So far, the MNS16A VNTR polymorphism of the hTERT catalytic subunit has been described in two lymphoproliferative disorders: first in our study on NHL, 27 and later in diffuse large B-cell lymphoma (DLBCL) 49. Our previous work identified some relationships between the VNTR-243 variant with more aggressive disease and with less favorable response to therapy 27.…”

Section: Discussionmentioning

confidence: 55%

“…Our previous work identified some relationships between the VNTR-243 variant with more aggressive disease and with less favorable response to therapy 27. The study on DLBCL revealed that Egyptian carriers of the S allele or the SS genotype of MNS16A were at higher risk of disease development 49. Wang et al investigated promoter activity of MNS16A VNTRs in lung cancer cells and showed that the shorter VNTR (S) variant correlated with lower promoter activity, while the longer VNTR (L) was associated with increased risk of lung cancer 24.…”

Section: Discussionmentioning

confidence: 99%

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Variability within the human TERT gene, telomere length and predisposition to chronic lymphocytic leukemia

Wysoczańska

Dratwa

Gębura

et al. 2019

OTT

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Background: The human telomerase reverse transcriptase ( TERT ) gene encodes the catalytic subunit of telomerase that is essential for maintenance of telomere length. We aimed to find out whether variability within the TERT gene could be associated with telomere length and development of the disease in non-treated patients with chronic lymphocytic leukemia (CLL). Materials and methods: Telomere length, rs2736100, rs2853690, rs33954691, rs35033501 single-nucleotide polymorphisms, and variable number of tandem repeats (VNTR-MNS16A) were assessed in patients at diagnosis. In addition, blood donors served as controls for the polymorphism studies. Results: The minor rs35033501 A variant was more frequent among CLL patients than in healthy controls (OR=3.488, p =0.039). CLL patients over 60 years of age were characterized with lower disease stage at diagnosis ( p =0.001 and p =0.008, for the Rai and Binet criteria, respectively). The MNS16A VNTR-243 short allele was more frequent in patients with a low disease stage ( p =0.020 and p =0.028, for the Rai and Binet staging system) and also among older patients having longer telomeres ( p =0.046). Patients with Rai 0–I stage were characterized with longer telomeres than those with more advanced disease ( p =0.030). This relationship was especially pronounced in patients carrying the rs2736100 C allele, independently of the criteria used, ie, Binet ( p =0.048) or Rai ( p =0.001). Conclusion: Our results showed that the genetic variation within the TERT gene seems to play a regulatory role in CLL and telomere length.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Variability within the human TERT gene, telomere length and predisposition to chronic lymphocytic leukemia

Wysoczańska

Dratwa

Gębura

et al. 2019

OTT

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“…Mature B‐cell lymphoma is collectively the 10th most common cancer worldwide, with nearly 386,000 new diagnoses annually (2012 Cancer Research UK statistics), and of these 40% are DLBCL. In recent years, many studies have confirmed that genetic factors, especially the single nucleotide polymorphism (SNP), are closely associated with the susceptibility of DLBCL …”

Section: Introductionmentioning

confidence: 99%

“…In recent years, many studies have confirmed that genetic factors, especially the single nucleotide polymorphism (SNP), are closely associated with the susceptibility of DLBCL. [2][3][4] MicroRNAs (miRNAs) are 17 to 25-nucleotide noncoding RNAs that can modulate the expression of target genes. Accumulating evidence has shown that miRNA might play critical roles in cancer initiation and the progression processes, 5 including DLBCL.…”

Section: Introductionmentioning

confidence: 99%

Pre‐miR‐27a rs895819 polymorphism and risk of diffuse large B‐cell lymphoma

Tang

et al. 2019

Clinical Laboratory Analysis

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Background Recently, several studies have investigated the relationship between Pre‐miR‐27a rs895819 polymorphism and risk of various cancers. However, the relationship between rs895819 and diffuse large B‐cell lymphoma (DLBCL) has not been well known. Methods In this study, we conducted a case‐control study to explore the role of Pre‐miR‐27a rs895819 in risk of DLBCL. The PCR‐TaqMan and luciferase assays and in vitro experiments were used to evaluate polymorphism function. Results As a result, we found subjects carrying with rs895819 AG/GG genotype had a significantly decreased risk when compared with those carrying the AA genotype. Further qPCR assay showed that the DLBCL patients carrying AG/GG genotypes showed a lower level of mature miR‐27a when compared with patients carrying AA genotype. Moreover, miR‐27a levels were upregulated in DLBCL tissues compared with normal lymphoid tissues. Further in vitro experiments showed that miR‐27a might function as an oncogene through target TGFBR1. In addition, TGFBR1 overexpression rescues effects of miR‐27a inhibitor on DLBCL cells phenotypes. Conclusions In conclusion, these findings indicate that rs895819 A > G might reduce the expression of mature miR‐27a, and leading a higher level of TGFBR1, ultimately inhibiting the development of DLBCL.

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“…rs2736098 has been suggested to be significantly associated with carcinogenesis in multiple tissues besides breast, including lung, basal cell, bladder, prostate, cervix, liver, pancreas, colon, ovary, B cell, head and neck [ [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] ]. Further search in GWAS Catalog, UK BioBank ( https://www.ukbiobank.ac.uk ) and FinnGen ( https://www.finngen.fi/fi ) indicate that rs2736098 is also significantly associated with count of platelet, red and white blood cell, neutrophil, basophil neutrophil and monocyte (all P < 5 × 10 −8 ; results not shown) [ [42] , [43] , [44] ].…”

Section: Discussionmentioning

confidence: 99%

rs2736098, a synonymous polymorphism, is associated with carcinogenesis and cell count in multiple tissue types by regulating TERT expression

Zhang,

Yu,

et al. 2024

Heliyon

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Association of MNS16A VNTR and hTERT rs2736098: G>A polymorphisms with susceptibility to diffuse large B-cell lymphoma

Abstract: MNS16A genetic variations are associated with DLBCL susceptibility.

Cited by 7 publications

References 29 publications

<p>Variability within the human <em>TERT</em> gene, telomere length and predisposition to chronic lymphocytic leukemia</p>

<p>Variability within the human <em>TERT</em> gene, telomere length and predisposition to chronic lymphocytic leukemia</p>

Pre‐miR‐27a rs895819 polymorphism and risk of diffuse large B‐cell lymphoma

rs2736098, a synonymous polymorphism, is associated with carcinogenesis and cell count in multiple tissue types by regulating TERT expression

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