Association of n‐6 long‐chain polyunsaturated fatty acids to −866 G/A genotypes of the human uncoupling protein 2 gene in obese children

Abstract

Significantly lower values of C20:3n-6 can be detected in obese children with the homozygous (-866 A/A) mutation of UCP2 than in equally obese children with heterozygous mutation or the normal genotype. High glucose-stimulated insulin response is associated with high plasma C20:3n-6 and C20:4n-6 values only in obese children with the G allele of the -866 G/A polymorphism.