According to our results, clinically healthy obese children have a higher degree of albuminuria and beta-2-microglobulinuria than normal weight children, indicating early renal glomerular and tubular dysfunction as a consequence of childhood obesity. The urinary albumin/creatinine ratio in the obese children was associated with certain metabolic derangements linked to obesity, and also with the clustering of features of the metabolic syndrome.

These findings suggest that promoting MVPA may be have a beneficial effect on attention capacity, an important component of cognition, in adolescents.

Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention.

Objective: To estimate the frequency of Arg64 allele of the b 3 -adrenergic receptor (3-BAR) gene in healthy (H) and obese (O) Hungarian children, and to look for possible associations between this polymorphism and some clinical and metabolic characteristics of obese children. Patients/methods: In all, 147 healthy (male: 68) and 295 obese (male: 168) children were examined. The average age of the children in the two groups was 12.471.7 vs 12.673.2, respectively. Exon 1 of 3-BAR was amplified by polymerase chain reaction and the fragments were digested with BstN1. In obese children, oral glucose tolerance test was carried out and blood pressure (BP) was checked. Results: The frequency of Trp64Arg polymorphism in normal and obese Hungarian children was similar (H vs O: n ¼ 14/9.5% vs n ¼ 35/11.8%). Obese children carrying the Arg64 allele (n ¼ 35, male: 23) were compared to randomly chosen, obese children without the Arg64 allele (n ¼ 35, male: 20). A significant difference was found between the body weight (81.2723.2 vs 75.6717.7 kg; mean7s.d.; Po0.01), body fat (38.873.9 vs 36.572.3%; mean7s.d.; Po0.05), mean fasting insulin levels (31.4716.7 vs 16.977.6 mIU/ml; Po0.001) and mean systolic BP values (125.2710.1 vs 114.578.3 mmHg; Po0.001) of the two obese groups. Conclusions: The frequency of Trp64Arg polymorphism was similar in Hungary as compared to other European countries. Although the prevalence of this polymorphism was similar in H and O children, the presence of Arg64 allele seems to be associated with increased adiposity, elevated systolic BP and higher fasting insulin levels.European Journal of Clinical Nutrition (2005) 59, 955-959.

No abstract