Association of OPG gene polymorphisms with the risk of knee osteoarthritis among Chinese people

Abstract

Background Osteoarthritis (OA) is usually recognized to have a genetic factor, and in our study, we performed a case–control study to analyze the association between 14 single nucleotide polymorphisms (SNPs) in OPG and the risk of knee OA in a Chinese Han population. Methods Fourteen OPG SNPs were assayed using MassARRAY in 393 patients clinically and radiographically diagnosed with knee OA and in 500 controls. Allelic and genotypic frequencies were compared between the groups. Logistic regression adjusting for age and gender was used to estimate risk associations between specific genotypes and knee OA by computing odds ratios (ORs) and 95% confidence intervals (95% CIs). Results We found that the minor alleles of six SNPs in OPG were associated with an increased or decreased risk of knee OA in the allelic model analysis. In the genetic model analysis, we found that rs1905786, rs1032128, rs3134058, rs11573828, rs11573849, rs3134056, and rs1564861 were associated with an increased or decreased risk of knee OA before adjusted by sex and age. And after adjustment, three SNPs (rs1485286, rs1905786, and rs1032128) were identified to have a negative effect on knee OA. Conclusion Our results verify that genetic variants of OPG contribute to knee OA susceptibility in the population of northern China. These genetic associations may identify individuals at a particularly high risk of developing knee OA.

Caracterização de polimorfismos nos genes OPG, RANK e RANKL em uma população brasileira

“…Em relação ao rs1032128 em OPG que na população estudada teve a frequência do menor alelo A de 29% (Tabela 5), foi relacionado com diversas doenças, como pé diabético, numa população polonesa, onde o alelo A foi considerado alelo de risco para essa condição patológica (MROZIKIEWICZ- RALO-WSKA et al, 2018). O mesmo polimorfismo apresentou relação com o desenvolvimento da osteoporose da cabeça femoral, induzida por álcool, em um modelo recessivo, no genótipo GG, também numa população chinesa (LI et al, 2016), bem como efeito negativo do menor alelo G para a osteoartrite de joelho numa população chinesa (QI et al, 2019). O alelo ancestral G na população deste estudo teve frequência de 71% (Tabela 5).…”