2014
DOI: 10.1111/ijd.12570
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Association of HLA‐B*1502 allele with lamotrigine‐induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Han Chinese subjects: a meta‐analysis

Abstract: We found a statistical association between HLA-B*1502 and lamotrigine-induced SJS/TEN in Han Chinese subjects. Future studies with larger sample sizes are suggested to verify the results.

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Cited by 41 publications
(25 citation statements)
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“…Among these drugs, the carbamazepine was the most frequent due to its use not only in epilepsy but also in other painful syndromes such as trigeminal neuralgia, neuropathic pain and others. Several pharmacogenomics studies carried out in the Asian and European population [29][30][31] Otherstudies have shown that bacterial infections were the second most common underlying condition that indicated the use of these antibiotics. This result is consistent with previous studies [21,24].…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Among these drugs, the carbamazepine was the most frequent due to its use not only in epilepsy but also in other painful syndromes such as trigeminal neuralgia, neuropathic pain and others. Several pharmacogenomics studies carried out in the Asian and European population [29][30][31] Otherstudies have shown that bacterial infections were the second most common underlying condition that indicated the use of these antibiotics. This result is consistent with previous studies [21,24].…”
mentioning
confidence: 99%
“…15], 3.5[2.5-5.5], 3 days[1][2][3][4][5][6][7], respectively) and longer for DRESS-DiHS (7 days[3][4][5][6][7][8][9][10]). In the only case of overlapping SJS/TEN, the treatment started 21 days after the reaction started.The median of the treatment duration was 14 (IQR 7-30) days, being 21(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) days for DRESS-DiHS, 6 (3-19.5) days for TEN and 10 (8-11) days for SJS. All the patients with AGEP received treatment during 14 days…”
mentioning
confidence: 99%
“…[ 6 13 ] According to a meta-analysis done by Zeng et al ., there are only six studies that have looked into the association of HLA gene with LTG -induced SJS/TEN, of which four found an association with HLA-B*15:02 in Han Chinese cases While the other two (in the European population) did not. [ 14 ] Furthermore, positive association was found between HLA B*1502 and LTG-SJS/TEN in the Han Chinese Population of in Hong Kong, Taiwan, and Mainland China in another meta-analysis. [ 15 ] Although we also found HLA-B*15:02 in one of our LTG-induced SJS/TEN patients, a case–control study must be done in the Indian population to look for the association of specific HLA alleles in LTG-induced cADRs.…”
Section: Discussionmentioning
confidence: 99%
“…For selected ethnic groups a genetic predisposition has been identified: HLA-B*15:02 in Han Chinese (odds ratio 4.98, 95% confidence interval 1.43-17.28), HLA-B*44:03 and HLA-B*38:01 alleles as a probable risk factor for SJS/TEN in the Korean population [37,38,39]. HLA-A*24:02 was recently confirmed as a shared risk factor for SJS/ TEN after exposure to aromatic AEDs, including LTG [40].…”
Section: Lamotriginementioning
confidence: 99%