Association of <i><scp>LTA</scp></i> gene haploblock with periodontal disease in Italian adults

Zupin, Luisa; Moura, Ronald; Navarra, Chiara Ottavia; Bevilacqua, Lorenzo; Catamo, Eulalia; Lenarda, Roberto Di; Gasparini, Paolo; Crovella, Sérgio; Robino, Antonietta

doi:10.1111/jre.12609

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Nine hundred forty-nine individuals from isolated villages located in the north-east of Italy (Erto–Casso, Clauzetto, Illegio, Sauris, and Val di Resia) voluntarily participated, between March 2008 and November 2008, in the dental examination organized within the “FVG Genetic Park” project, as part of a wider research program aimed at the identification of factors associated with common diseases and traits [ 21 , 23 ]. Inhabitants of these villages were invited to participate by public advertisements through local authorities, television, newspapers, local physicians’ involvement, and mailing.…”

Section: Methodsmentioning

confidence: 99%

“…Being enriched by a complex demographic history and topographic variability, Italians are thus one of the most studied European populations [ 19 , 20 , 21 ]. Regarding the study of oral health conditions in isolated populations, the literature reports some studies on dental caries and periodontal disease in Italian isolated communities [ 22 , 23 , 24 ], but a thorough search of the relevant literature highlighted that few studies on the prevalence and distribution of orthodontic traits and of other odontostomatological traits, such as breathing pattern, TMDs, and dentition, are available. Taking into account the current literature picture, the present study aims to deepen the knowledge of the epidemiology of odontostomatological traits in isolated populations of north-eastern Italy within the context of the wider project named “Friuli-Venezia Giulia (FVG) Genetic Park” [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Odontostomatological Traits in North-Eastern Italy’s Isolated Populations: An Epidemiological Cross-Sectional Study

Luppieri

Pecori

Spedicati

et al. 2023

JCM

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Malocclusions and temporomandibular disorders (TMDs) are oral health problems that are spread worldwide. To date, few studies focused on their prevalence and associated risk factors are available. This study aims to define the prevalence and distribution of odontostomatological traits and evaluate specific risk factors in isolated villages in north-eastern Italy, taking advantage of their environmental homogeneity. Nine hundred and forty-four participants aged six to eighty-nine years were enrolled. Thirty-one odontostomatological phenotypes, classified into five domains (airways, bad habits, extraoral and intraoral parameters, TMDs, and teeth), were evaluated. A descriptive statistical analysis was performed; mixed logistic models were used to test the relationships among the traits. According to the study’s findings, Angle’s class I was prevalent (65.3%) followed by class II malocclusion (24.3%); class III and reversed overjet were the least frequent malocclusions (10.4% and 1.8%, respectively). Temporomandibular joint (TMJ) click/noise was prevalent among TMDs (34.7%). The statistically significant (p-value < 0.05) risk factors were ankyloglossia for phonetic issues (OR 1.90) and bruxism for TMJ click/noise (OR 1.70) and pain (OR 2.20). Overall, this work provides a picture of the prevalence of malocclusions and TMDs in a large Italian sample and reveals risk factors to take into account in the development of preventive strategies and treatments.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Odontostomatological Traits in North-Eastern Italy’s Isolated Populations: An Epidemiological Cross-Sectional Study

Luppieri

Pecori

Spedicati

et al. 2023

JCM

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Infectious Triggers in Periodontitis and the Gut in Rheumatoid Arthritis (RA): A Complex Story About Association and Causality

et al. 2020

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Rheumatoid arthritis (RA) is a systemic immune mediated inflammatory disease of unknown origin, which is predominantly affecting the joints. Antibodies against citrullinated peptides are a rather specific immunological hallmark of this heterogeneous entity. Furthermore, certain sequences of the third hypervariable region of human leukocyte antigen (HLA)-DR class II major histocompatibility (MHC) molecules, the so called "shared epitope" sequences, appear to promote autoantibody positive types of RA. However, MHC-II molecule and other genetic associations with RA could not be linked to immune responses against specific citrullinated peptides, nor do genetic factors fully explain the origin of RA. Consequently, non-genetic factors must play an important role in the complex interaction of endogenous and exogenous disease factors. Tobacco smoking was the first environmental factor that was associated with onset and severity of RA. Notably, smoking is also an established risk factor for oral diseases. Furthermore, smoking is associated with extra-articular RA manifestations such as interstitial lung disease in anatomical proximity to the airway mucosa, but also with subcutaneous rheumatoid nodules. In the mouth, Porphyromonas gingivalis is a periodontal pathogen with unique citrullinating capacity of foreign microbial antigens as well as candidate RA autoantigens. Although the original hypothesis that this single pathogen is causative for RA remained unproven, epidemiological as well as experimental evidence linking periodontitis (PD) with RA is rapidly accumulating. Other periopathogens such as Aggregatibacter actinomycetemcomitans and Prevotella intermedia were also proposed to play a specific immunodominant role in context of RA. However, demonstration of T cell reactivity against citrullinated, MHC-II presented autoantigens from RA synovium coinciding with immunity against Prevotella copri (Pc.), a gut microbe attracted attention to another mucosal site, the intestine. Pc. was accumulated in the feces of clinically healthy subjects with citrulline directed immune responses and was correlated with RA onset. In conclusion, we retrieved more than one line of evidence for mucosal sites and different microbial taxa to be potentially involved in the development of RA. This review gives an overview of infectious agents and mucosal pathologies, and discusses the current evidence for causality between different exogenous or mucosal factors and systemic inflammation in RA.

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Genetic predictors of periodontitis development: problems and prospects (a literature review)

Tikhomirova

2022

Parodontologiâ

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Relevance. Currently, researchers are actively searching for genetic markers of periodontitis. Their detection will allow identifying risk group patients long before the manifestation of the first signs of the disease, predicting the disease course and intensively carrying out preventive measures to eliminate negative environmental factors.Aim – to classify the available data on the genes associated with the development of aggressive and chronic generalized periodontitis.Materials and methods. We found 214 publications published from 2005 to 2020 in the electronic databases PubMed, Google Search and eLibrary. One hundred and thirty-five publications were selected, among which are clinical studies and meta-analysis data.Results. Chronic inflammatory diseases such as periodontitis are typically polygenic. The disease-associated genes are predisposition genes. The presence of an allele associated with the disease in an individual is not an absolute diagnostic sign for the development of the disease. However, it reflects the risk of disease development. The search for genetic markers of periodontitis assigns a crucial role to genes, which encode proteins significant at different stages of the pathogenesis of inflammatory periodontal diseases. Defensins, interleukins, Toll-like receptors, collagen type I α1 chain and others are among them. To date, the researchers have studied about 300 polymorphisms and have associated some of them with the development of periodontitis.Conclusion. The exact genetic marker of periodontitis is currently unknown. Further search for the candidate genes and additional knowledge of the pathogenesis of inflammatory periodontal diseases are necessary. Determining the disease predisposition will improve the quality of dental care and preventive measures even before the manifestation of the disease.

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Association of LTA gene haploblock with periodontal disease in Italian adults

Cited by 3 publications

References 32 publications

Odontostomatological Traits in North-Eastern Italy’s Isolated Populations: An Epidemiological Cross-Sectional Study

Odontostomatological Traits in North-Eastern Italy’s Isolated Populations: An Epidemiological Cross-Sectional Study

Infectious Triggers in Periodontitis and the Gut in Rheumatoid Arthritis (RA): A Complex Story About Association and Causality

Genetic predictors of periodontitis development: problems and prospects (a literature review)

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