Association of Ideal Cardiovascular Metrics and Serum High-Sensitivity C-Reactive Protein in Hypertensive Population

Abstract

Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) are associated with increased risk of cardiovascular disease. However, ideal cardiovascular health indicates lower risk of cardiovascular disease. This study aimed to investigate the effect of ideal cardiovascular health behaviors and health factors on hs-CRP levels among a hypertensive population. From 2006 to 2007, a cross-sectional study was conducted to survey 41,476 hypertensive subjects among the employees of Kailuan Corporation. Data from unified questionnaires and blood biochemical examinations were collected. The effects of ideal cardiovascular health behaviors and health factors on hs-CRP levels were evaluated through multivariate logistic regression analysis. A negative correlation was observed between hs-CRP levels and the number of ideal cardiovascular health metrics. The mean hs-CRP levels of subjects with zero to one, two, three, and four to six ideal cardiovascular health metrics were 1.11, 0.96, 0.90, and 0.80 mg/L, respectively (P<0.01). Multivariate logistic regression analysis revealed that after adjustment for sex, age, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and other risk factors, the risks for subjects with two, three, and four to six ideal health metrics with serum hs-CRP >3 mg/L were lower than those with zero to one ideal health metrics, with corresponding odd ratios of 0.86 (95%CI: 0.79–0.93, P<0.01), 0.76 (95%CI: 0.69–0.83, P<0.01), and 0.68 (95%CI: 0.64–0.75, P<0.01), respectively. This finding suggests that ideal cardiovascular health behaviors and health factors were related to decreased hs-CRP levels in a hypertensive population.Clinical Trial RegistrationUnique identifier: ChiCTR-TNC-11001489.

Independent and joint associations of blood lipids and lipoproteins with lung cancer risk in Chinese males: A prospective cohort study

“…The data were derived from the Kailuan study, an ongoing prospective dynamic cohort study of currently working and retired employees of the Kailuan Group in Tangshan City in Hebei Province, north of China. Tangshan, approximately 90 miles southeast of Beijing, represents the overall population of China from a socioeconomic perspective . Over the past few decades, the Kailuan Group has developed a comprehensive company managing coal production, machine manufacturing, transportation, chemical production, education, and healthcare, etc.…”

“…Tangshan, approximately 90 miles southeast of Beijing, represents the overall population of China from a socioeconomic perspective. 20 Over the past few decades, the Kailuan Group has developed a comprehensive company managing coal production, machine manufacturing, transportation, chemical production, education, and healthcare, etc. The methodology of and rationale for the Kailuan study have been described previously.…”

High Sensitivity C-Reactive Protein Predictive Value for Cardiovascular Disease: A Nested Case Control from Isfahan Cohort Study (ICS)

“…High sensitivity method are used to measure this acute phase reactant protein, which introduced a novel biomarker named high sensitivity CRP (hs-CRP). This novel biomarker is associated with raising the incidence of cardiovascular events and their major contributing factors including HTN and arterial stiffness as well as atheromatous plaque rupture [8,[13][14][15][16][17][18][19][20]. Despite its usefulness, the relationship between this novel marker and CVDs in presence of major CVDs risk factors needs to be identified.…”

Association of Ideal Cardiovascular Health and Brachial–Ankle Pulse Wave Velocity: A Cross-Sectional Study in Northern China

“…21,22 However, there has been little research on the association between the ideal CVH score and PWV, particularly from a different angle (baPWV). We therefore evaluated the association between the CVH score and baPWV among Chinese adults in a large community-based Asymptomatic Polyvascular Abnormalities in Community (APAC) Study in northern China.…”