Association of IL-10 GTC haplotype with serum level and HPV infection in the development of cervical carcinoma

Abstract

IL-10 polymorphisms play a role in cervical cancer development and that GTC haplotype, which is closely related to its serum concentration, maybe a useful biomarker for HPV-mediated cervical cancer.

IL-10 gene promoter and intron polymorphisms as genetic biomarkers of cervical cancer susceptibility among Tunisians

“…IL-10-1082 polymorphism has been found to be associated with CC development in populations from Zimbabwe, Japan and India [18,26,27]. In contrast to these studies, our findings and several from other populations in South Africa, Netherlands, Hungary and Argentine failed to find any association of this variant with CC [15,16,28,29].…”

“…Similar results for IL-10-592 but not for IL-10-819 are revealed in breast cancer patients [30]. However, opposite finding was revealed among Korean and Indian CC women [14,16,18,31,32]. The discrepancy may be explained by ethnic differences, selection of cases from the analyzed population and hence diseases association.…”

“…The GTC haplotype, which was found to be associated crease the risk of CC [18,35] while ATA of IL-10 and HPV infection appeared as a protective factor among Indian women [35] and ACA with higher serum concentration was seemed as a marker for precancerous lesion [18].…”

“…Some studies have reported high levels of IL-10 in CC patients, suggesting that the presence of IL-10 is directly associated with the degree of cervical lesion [20][21][22][23][24]. A number of genetic polymorphisms have been implicated in the modulation of IL-10 production and alter the susceptibility to CC [18,25,26] but the results are still controversial. These includes three polymorphic sites in the promoter region of IL-10 gene, rs1800896 (À1082 A/G), rs1800871 (À819 T/C), and rs1800872 (À592 A/C).…”

“…has been reported that several important polymorphic sites in the IL-10 gene, appears to be responsible with modulated levels of IL-10 [11][12][13]. The association of IL-10 promoter SNPs with CC has been reported by several studies, but with inconclusive findings [14][15][16][17][18].…”