Association of IL-27 rs153109 and rs17855750 Polymorphisms with Risk and Response to Therapy in Acute Lymphoblastic Leukemia

Ghavami, Alireza; Fathpour, Gholamreza; Amirghofran, Zahra

doi:10.1007/s12253-017-0295-2

Cited by 15 publications

(12 citation statements)

References 34 publications

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“…Our previous team work had proved that serum IL-27 level was higher in the PL group than women in the TL group [25]. In the present study, qPCR test ( Fig.…”

Section: Expression Of Il-27rα In Human Fms In Ptli and Tl Groupsupporting

confidence: 57%

The Immuno-Inflammatory Effect of IL-27 in Preterm Labor

Mei

Ran

liu

et al. 2021

Preprint

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Objective To investigate the effect of IL-27 on Th1 cells infiltration in human fetal membranes (FMs) and the underlying mechanisms in preterm labor. Methods The expression of IL-27 receptor a subunit (IL-27R𝛼) and Th1 cells were studied in human FMs from pregnant women with preterm labor (PL) and term labor (TL). In vitro, we investigated the effects of IL-27 in human amniotic cell lineage on the Th1 related chemokines and adhesive molecules and the underlying intracellular signaling molecules. Results The expression of IL-27R𝛼 was higher in human fetal membranes from PL group compared with TL group. Compared with TL group, the PL group had more Th1 cells infiltration in human FMs. Meanwhile, it was confirmed the expression of CXCL9, CXCL10, CXCL11 and ICAM-1 were higher in FMs from PL group to TL group. Moreover, IL-27 stimulation can up-regulate the expression of those chemokines in human amniotic cell lineage via JAK2/STAT1/STAT3 signaling pathway. Conclusions The expression of IL-27R𝛼 and number of Th1 cells infiltration were higher at FMs of PL group than TL group. IL-27 could promote Th1 related chemokines and adhesive molecules in human amniotic cell lineage mainly through JAK2/STAT1/STAT3 signaling pathway.

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“…Our previous team work had proved that serum IL-27 level was higher in the PL group than women in the TL group [25]. In the present study, qPCR test ( Fig.…”

Section: Expression Of Il-27rα In Human Fms In Ptli and Tl Groupsupporting

confidence: 57%

The Immuno-Inflammatory Effect of IL-27 in Preterm Labor

Mei

Ran

liu

et al. 2021

Preprint

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“…Several studies examined the association between DOI:10.31557/APJCP.2020.21.9.2507 IL-27 polymorphisms and the risk of various cancer (Wei et al, 2009;Zhao et al, 2009;Guo et al, 2012;Huang et al, 2012;Pan et al, 2012;Tao et al, 2012;Peng et al, 2013;Munretnam et al, 2014;Tang et al, 2014;Zhang et al, 2014a;Zhang et al, 2014b;Lyu et al, 2015;Pu et al, 2015;Zhang et al, 2015;Zhou et al, 2015;Ge and Xiao, 2016;Wang et al, 2016;Yu et al, 2016;Nie et al, 2017;Ghavami et al, 2018). The findings were controversial, though it is difficult to clarify the inconsistent findings.…”

Section: Discussionmentioning

confidence: 99%

“…It is well-known that IL-27 possesses antitumor activities against a variety of tumor types (Nagai et al, 2010;Di Carlo et al, 2014;Yoshida and Hunter, 2015;Yoshimoto et al, 2015). IL-27 is a polymorphic gene and several studies examined the association between IL-27 gene polymorphisms and risk of various cancers including, non-small-cell lung cancer (NSCLC) (Ge and Xiao, 2016), acute lymphoblastic leukemia (ALL) (Ghavami et al, 2018), nasopharyngeal carcinoma (NPC) (Wei et al, 2009;Pan et al, 2012), colorectal cancer (CRC) (Guo et al, 2012;Huang et al, 2012;Lyu et al, 2015), prostate cancer (PCa) (Munretnam et al, 2014), papillary thyroid carcinoma (PTC) (Zhang et al, 2015;Nie et al, 2017), hepatocellular carcinoma (HCC) (Peng et al, 2013), renal cell carcinoma (RCC) (Pu et al, 2015), osteosarcoma (Tang et al, 2014), esophageal cancer (Tao et al, 2012), cervical cancer (Wang et al, 2016), endometrial cancer (Yu et al, 2016), ovarian cancer (Zhang et al, 2014b), breast cancer (Zhang et al, 2014a), glioma (Zhao et al, 2009), and bladder cancer (Zhou et al, 2015). However, the findings of these studies have been controversial.…”

Section: Introductionmentioning

confidence: 99%

Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

Moazeni‐Roodi

Hashemi

Ghavami

2020

Asian Pac J Cancer Prev

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Background: Interleukin 27 (IL-27) has potent antitumor activity. Several epidemiological studies have designated that genetic variants of the IL-27 gene may contribute to various cancer susceptibility, but the data were inconclusive. Objective: The current meta-analysis aimed to address the association between IL-27 rs153109, rs17855750, and rs181206 polymorphisms and the risk of cancer. Data Sources: Our team has selected eligible studies up to May 1, 2020, from several electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar databases. Results: Our meta-analysis revealed that the carriers rs153109 A>G polymorphism in the IL-27 gene have higher risks of diseases in the heterozygous (OR=1.26, 95%CI=1.06-1.49, P=0.007, AG vs AA), homozygous (OR=1.18, 95%CI=1.01-1.37, p=0.33, GG vs AA), dominant (OR=1.25, 95%CI=1.07-1.47, P=0.006, AG+GG vs AA), and allele (OR=1.15, 95%CI=1.04-1.27, P=0.008, G vs A) genetic models. Stratified analysis by cancer type indicated that this variant was significantly associated with gastrointestinal cancer, colorectal cancer and breast cancer. The findings did not support an association between rs17855750 T>G, rs181206 T>C polymorphisms of IL-27 and cancer risk. Conclusion: the current study findings suggest that IL-27 rs153109 polymorphism significantly increased the risk of cancer susceptibility. Well-designed replication in a larger independent genetic association study with larger sample sizes in diverse ethnicities is required to verify the findings.

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“…In caecal ligation puncture-induced lung in ammation mice model, elevated IL-27 levels were observed in the lung, serum, and bronchoalveolar lavage uids, and IL-27 neutralizing antibody could reduce lung injury and improve survival [12,13]. Our previous team work also demonstrated that IL-27 could induce a proin ammatory response in human fetal membrane, mediating in preterm labor [14]. In regards of the above evidence, we hypothesized that IL-27 could participate in PTLI by regulating neutrophils in ltration at the maternal and fetal interface.…”

Section: Introductionmentioning

confidence: 90%

IL-27 Mediates Neutrophils Infiltration at the Maternal and Fetal Interface in Preterm Labor With Infection

Mei

Huang

Ran

et al. 2021

Preprint

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Objective To reveal the role of IL-27 in neutrophils infiltration at the maternal and fetal interface in preterm labor with infection (PTLI). Methods The expression of IL-27 receptor and the number of neutrophils (MPO + cells) at the maternal and fetal interface of pregnant women were compared between PTLI group and term labor (TL) group. Using LPS-induced preterm labor IL-27Rα-/- mice, the role of IL-27 in neutrophils infiltration at the maternal and fetal interface was investigated. Results The expression of IL-27Rα and neutrophils number at the maternal and fetal interface in the PTLI group were higher than those in the TL group in pregnant women. Compared with PBS-treated mice, LPS-treated mice had increased infiltrating neutrophils at the maternal and fetal interface. Meanwhile, LPS-induced IL-27Rα-/- mice had less neutrophil infiltration than LPS-induced WT mice. Conclusion IL-27 promotes neutrophil infiltration at the maternal and fetal interface in PTLI.

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Association of IL-27 rs153109 and rs17855750 Polymorphisms with Risk and Response to Therapy in Acute Lymphoblastic Leukemia

Cited by 15 publications

References 34 publications

The Immuno-Inflammatory Effect of IL-27 in Preterm Labor

The Immuno-Inflammatory Effect of IL-27 in Preterm Labor

Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

IL-27 Mediates Neutrophils Infiltration at the Maternal and Fetal Interface in Preterm Labor With Infection

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