Association of IL-5 cytokine production and in vivo IgE levels in infants and parents

Crestani, Elena; Lohman, I. Carla; Guerra, Stefano; Wright, Anne L.; Halonen, Marilyn

doi:10.1016/j.jaci.2007.05.033

Cited by 19 publications

(18 citation statements)

References 36 publications

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“…It has been reported that this cytokine can increase the synthesis of IgE mediated by IL-4 in both human and murine B cells. It is also known that this cytokine, together with IL-4, provides the signal required for the switching to IgG1 and IgE in mice [7]. …”

Section: Discussionmentioning

confidence: 99%

“…This Th2 scenario induces the secretion of high levels of IgE, together with the recruitment of effector cells, that is, eosinophils, basophils and mast cells to the site where the allergic inflammatory response is taking place [5,6,7,8,9]. On the other hand, it is known that in healthy individuals, a Th1 response is generated against these allergens [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preliminary Studies on the Prevention of the Ovalbumin-Induced Allergic Response by <i>Enterococcus faecalis</i> CECT7121 in Mice

Castro

Azpiroz

Molina

et al. 2011

Int Arch Allergy Immunol

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Background: Allergic diseases are featured by an increased production of IgE due to an imbalance in the immune response towards a Th2 profile. In this work, the ability of Enterococcus faecalis CECT7121 to regulate this Th2-exaggerated response in a murine model of ovalbumin (OVA)-induced allergy was studied. Methods: BALB/c mice intragastrically inoculated with E. faecalis CECT7121 before and during a subcutaneous immunization protocol with OVA were studied in comparison with an immunized control group. The allergen-specific immune response (IgE, IgG, IgG1 and IgG2a) was assessed. The proliferative activity of memory splenocytes and the levels of IL-4, IL-5, IL-13, IL-10, IL-12 and IFN-γ were also determined. Results: Upon treatment with E. faecalis CECT7121 the following effects were observed: (1) a decrease in specific IgE levels, (2) an increase in anti-OVA IgG2a levels, (3) the levels of anti-OVA IgG and IgG1 remained unaltered, (4) a reduction in the proliferation rate of memory cells, (5) a decrease in the levels of the Th2 cytokines IL-4, IL-5 and IL-13, and (6) the secretion of IL-10, IL-12 and IFN-γ remained unchanged. Moreover, the incubation of human basophils with non-viable E. faecalis CECT7121 together with an allergen preparation induced the release of β-hexosaminidase at levels that were lower than control reactions and similar i.g. the spontaneous release. Conclusions: In this model, the i.g. administration of E. faecalis CECT7121 hampers the establishment of the OVA-induced allergic immune response, suggesting that this strain could be useful for the treatment of IgE-mediated allergic diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preliminary Studies on the Prevention of the Ovalbumin-Induced Allergic Response by <i>Enterococcus faecalis</i> CECT7121 in Mice

Castro

Azpiroz

Molina

et al. 2011

Int Arch Allergy Immunol

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“…While the natural history of asthma and its relation to allergic responses from age 8–10 years into adulthood has been well studied [3], early life events play a critical role in determining the pattern of immune maturation and the development of allergic disease and particularly asthma [4]. However, current understanding of these events is limited by the nature of the available data.…”

Section: Introductionmentioning

confidence: 99%

Allergen-Specific IL-5 Responses in Early Childhood Predict Asthma at Age Eight

et al. 2014

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BackgroundThe pattern of development of allergen-specific T cell cytokine responses in early childhood and their relation to later disease is poorly understood. Here we describe longitudinal changes in allergen-stimulated T cell cytokine responses and their relation to asthma and allergic disease during the first 8 years of life.MethodsSubjects with a family history of asthma, who were enrolled antenatally in the Childhood Asthma Prevention Study (public trials registration number ACTRN12605000042640), had skin prick tests, clinical evaluation for asthma and eczema, and in vitro assessment of T cell cytokine responses to HDM extract performed at ages 18 months (n = 281), 3 years (n = 349), 5 years (n = 370) and 8 years (n = 275). We measured interleukin (IL-) 13 at 3, 5 and 8 years, and IL-5, IL-10, and interferon-γ (IFN-γ), at 18 months, 3, 5 and 8 years by ELISA. A cohort analysis was undertaken. Independent effects of cytokine responses at each age on the risk of asthma and allergic outcomes at age 8 years were estimated by multivariable logistic regression.ResultsHDM-specific IL-5 responses increased with age. HDM-specific IL-13 and IL-10 responses peaked at age 5 years. HDM-specific IL-5 responses at 3 years, 5 years and 8 years were significantly associated with the presence of asthma and atopy at 8 years. IL-13 responses at 3 years, 5 years and 8 years were significantly associated with atopy at 8 years, but this association was not independent of the effect of IL-5. Other HDM-specific cytokine responses were not independently related to asthma or eczema at 8 years.ConclusionHDM-specific IL-5 responses at age 3 years or later are the best measure of T cell function for predicting asthma at age 8 years.

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“…14 Higher local IgE levels were associated with more severe exacerbations of asthma. 14 Crestani et al 15 have also noted an association between IgE levels and the eosinophil-active cytokine IL-5 in infants and their parents.…”

Section: Igementioning

confidence: 94%

New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007

Broide

2008

Journal of Allergy and Clinical Immunology

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Association of IL-5 cytokine production and in vivo IgE levels in infants and parents

Cited by 19 publications

References 36 publications

Preliminary Studies on the Prevention of the Ovalbumin-Induced Allergic Response by <i>Enterococcus faecalis</i> CECT7121 in Mice

Preliminary Studies on the Prevention of the Ovalbumin-Induced Allergic Response by <i>Enterococcus faecalis</i> CECT7121 in Mice

Allergen-Specific IL-5 Responses in Early Childhood Predict Asthma at Age Eight

New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007

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