Association of IL1 beta gene polymorphism and allograft functions in renal transplant recipients :a case control study from Kashmir Valley

Abstract

BackgroundCytokines have been found to be the important mediators during renal graft outcome. Therefore, we designed this study to investigate the role of recipients’ IL-1 β promoter (−511) and IL-1 β exon-5 (+3954) polymorphisms with the risk of graft outcome.MethodologyWe enrolled one hundred recipients of living-related renal transplants together with the age and sex matched controls from the healthy population not having any renal abnormality for this study. Genotype frequencies of the IL-1 β promoter (−511) and IL-1 β exon-5 (+3954) were analyzed using PCR-RFLP technique.ResultsOur results revealed significant differences in the healthy control group and patient group in IL 1β +3954 (p < 0.001). The frequency of variant type TT genotype was higher in RE group as compared to SGF and showed 4 fold risk of rejection (OR = 4.54, p < 0.069) although p value was not significant. The frequency of wild type CC genotype and CT was not significant (p value 0.89 and 0.74 respectively).ConclusionOur findings suggest that there is a prevalence of mutated allele of IL-1 gene cluster in our population, which may be responsible for renal dysfunction.

Evaluation of IL‐6 levels and +3954 polymorphism of IL‐1β in burning mouth syndrome: A systematic review and meta‐analysis

“…Polymorphic variations in IL‐1 genes are frequent and are associated with exacerbated inflammatory response. The single nucleotide polymorphism (SNP) +3954 C/T of IL‐1β is located in exon 5 rs1143634 13 . The T allele is related to a higher production of IL‐1 and it increases the inflammatory process 14 .…”

A systematic review and meta-analyses of the relationship between glutathione S-transferase gene polymorphisms and renal cell carcinoma susceptibility

“…Early diagnosis for the disease of RCC is very difficult, and the RCC etiology is complicated [ 4 , 8 ]. Gene polymorphisms are reported to be associated with susceptibility of many diseases [ 9 – 13 ]. Current evidence also shows some gene polymorphisms to be associated with RCC risk [ 14 – 17 ].…”