Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia

Sivaraj, Nagarjuna; Rachel, K. Vijaya; Suvvari, Tarun Kumar; Prasad, Shilaja; Boppana, Sri Harsha; Vegi, Pradeep Kumar

doi:10.1016/j.jri.2021.103463

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…So, if the DNA molecule breaks, which can lead to neural tube defects (NTDs), different types of syndromes can form in embryonic development during pregnancy [3]. MTHFD1 gene polymorphism is mainly associated with placental influence on recurrent pregnancy loss, congenital heart diseases in early infants, intrauterine growth restriction, preeclampsia, placental abruption, and fetal death [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Association of MTHFD1 G1958A Polymorphism with Gestational Diabetes Mellitus

Bunga,

Balaga,

Raju

et al. 2024

Cureus

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BackgroundThe MTHFD1 G1958A polymorphism is a common variation in the gene encoding methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), an enzyme crucial for folate metabolism. This study investigated the association between the MTHFD1 G1958A polymorphism, which is involved in folate metabolism, and gestational diabetes mellitus (GDM) risk. MethodsA case-control study was conducted and 304 pregnant women (152 with gestational diabetes as cases and 152 healthy pregnant as controls) participated in the study. The polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) techniques were used to determine the MTHFD1 1958G>A polymorphism genotypes. ResultsAnalysis of genotype frequencies revealed a statistically significant difference (p-value < 0.05) between the GDM group and the control group, suggesting a potential association between this gene variant and the development of GDM. Interestingly, while allele frequencies alone did not show a significant association with GDM risk, analysis in a recessive model (both severe and mild forms) demonstrated a strong link between the homozygous AA genotype and increased susceptibility to GDM. ConclusionThis study provides the first evidence linking the MTHFD1 G1958A polymorphism and GDM risk in an Indian setting. These findings warrant further investigation into the functional impact of the MTHFD1 G1958A polymorphism and its potential role in the pathogenesis of GDM.

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Section: Introductionmentioning

confidence: 99%

Association of MTHFD1 G1958A Polymorphism with Gestational Diabetes Mellitus

Bunga,

Balaga,

Raju

et al. 2024

Cureus

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“…Previous studies have shown that renalase ( RNLS ) gene polymorphisms were associated with many diseases, such as essential hypertension, PE [ 14 ] and gestational diabetes [ 15 ]. A recent study displayed that the interleukin 1 receptor type 1 ( IL1R1 ) rs2071374G variant could lead to an increased risk of PE [ 16 ]. The egl-9 family hypoxia inducible factor 1 ( EGLN1 ) rs479200 may have the potential to become a marker to evaluate the genetic predisposition to PE [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variations in Angiotensinogen Gene and Risk of Preeclampsia: A Pilot Study

Peng

Xie

et al. 2023

JCM

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Preeclampsia (PE) is a typical hypertensive disorders of pregnancy (HDP) which can cause substantial morbidity and mortality in both pregnant women and fetuses. The renin-angiotensin system (RAS) genes are the main HDP-causing genes, and Angiotensinogen (AGT) as the initial substrate can directly reflect the activity of the entire RAS. However, the association between AGT SNPs and PE risk has rarely been confirmed. This study was carried out to determine whether AGT SNPs could affect the risk of PE in 228 cases and 358 controls. The genotyping result revealed that the AGT rs7079 TT carrier was related to increased PE risk. Further stratified analysis illustrated that the rs7079 TT genotype significantly increased the PE risk in subgroups of Age < 35, BMI < 25, Albumin (ALB) ≥ 30 and Aspartate aminotransferase (AST) < 30. These findings demonstrated that the rs7079 might be a promising candidate SNP strongly associated with PE susceptibility.

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“…In this regard, emerging evidence proposes that excessive maternal inflammatory response with cytokine-mediated endothelial damage may play a role in PE’s pathogenesis. [ 25 , 26 ]…”

Section: Introductionmentioning

confidence: 99%

Cytokine-polymorphisms associated with Preeclampsia: A review

et al. 2022

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Background: Preeclampsia (PE) is a syndromic disorder that affects 2% to 8% of pregnancies and is diagnosed principally when hypertension appears in the second-d half of pregnancy. WHO estimates the incidence of PE to be seven times higher in developing countries than in developed countries. Severe preeclampsia/eclampsia is one of the most important causes of maternal mortality, associated with 50,000 to 100,000 annual deaths globally as well as serious fetal and neonatal morbidity and mortality, especially in developing countries. Even though evidence from family-based studies suggest PE has a heritable component, its etiology, and specific genetic contributions remain unclear. Many studies examining the genetic factors contributing to PE have been conducted, most of them are focused on single nucleotide polymorphisms (SNPs). Given that PE has a very important inflammatory component, is mandatory to examine cytokine-SNPs for elucidating all mechanisms involved in this pathology. In this review, we describe the most important cytokine-polymorphisms associated with the onset and development of PE. We aim to provide current and relevant evidence in this regard. Methods: We searched English databases such as PubMed and the National Center for Biotechnology Information. The publication time of the papers was set from the establishment of the databases to February 2022. All studies about Th1/Th2/Th17 cytokines polymorphisms were included in our study. Results: SNPs in IFN-γ, TNF-α, IL-4, IL-6, IL-10, IL-17A, and IL-22 are associated with the development, early-onset and severity of PE, being the Th1/Th2/Th17 responses affected by the presence of these SNPs. Conclusions: The changes in Th1/Th2/Th17 response modify processes such as placentation, control of inflammation, and vascular function. Nonetheless, association studies have shown different results depending on sample size, diagnostic, and population.

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Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia

Cited by 7 publications

References 23 publications

Association of MTHFD1 G1958A Polymorphism with Gestational Diabetes Mellitus

Association of MTHFD1 G1958A Polymorphism with Gestational Diabetes Mellitus

Genetic Variations in Angiotensinogen Gene and Risk of Preeclampsia: A Pilot Study

Cytokine-polymorphisms associated with Preeclampsia: A review

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