Association of Immune Status with Recurrent Anal Condylomata in Human Immunodeficiency Virus-Positive Patients

Sung, Ji Hyun; Ahn, Eun Jung; Oh, Heung‐Kwon; Park, Sei Hyeog

doi:10.3393/jksc.2012.28.6.294

Cited by 7 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Under conditions of decreased cellular immunity such as with HIV will increase the recurrence of condyloma acuminata. Study by Sung et al, (2012) show that the average recurrence time of anal condyloma acuminata lesions in HIV patients was 5.1 months with a range of 1.3 months to 14.2 months. Decreased plasma zinc levels also affected recurrence of anogenital condyloma acuminata due to a decrease in cellular immunity.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Plasma Zinc Levels Among HIV+ and HIV- Subjects Infected with Condyloma Acuminata

Wiraguna

Andriani

Adiguna

2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background:Condyloma acuminata is a type of human papilloma virus (HPV) infection in the anogenital area and often associated with immunosuppressive conditions, such as human immunodeficiency virus (HIV). Low plasma zinc levels could cause alteration of cellular immunity, leading to reduction of interleukin-2 (IL-2) and interferon-γ (IFN-γ), cytokines required for inhibition of HPV replication. Moreover, low plasma zinc levels could cause disruption of apoptotic regulation, results in the unimpeded proliferation of epithelial cells infected with HPV. This study aimed to compare the mean plasma zinc levels in condyloma acuminata patients with HIV and without HIV infection.Methods:This study used a cross-sectional method, involving 27 condyloma acuminata patients without HIV infection and 18 patients with HIV infection, who agreed to enroll and signed the informed consent. This study was conducted in the dermatology and venereology outpatient clinic in Sanglah Hospital and Kerti Praja Foundation, Denpasar. Bivariate analysis of the characteristics, age, sex orientation, location of lesion, clinical form of lesion, type of cases, duration of condyloma acuminata, age of the first sexual contact, comorbidity, treatment history, and mean plasma zinc level of condyloma acuminata patients with HIV and without HIV infection. The CD4+ cell count and history of ARV treatment were also obtained form patients with HIV infection.Results:A total of 45 subjects were diagnosed with condyloma acuminata, consisted of 27 subjects with condyloma acuminata without HIV infection and 18 subjects with HIV infection, showing average age of 32.04 ± 10.414. Mean plasma zinc levels in condyloma acuminata patients with HIV infection was significantly lower than subjects without HIV infection, and the difference in mean plasma zinc levels was 7.31 µg/dL (95% CI 2.25 - 12.37, p <0.05).Conclusions:The mean plasma zinc levels in condyloma acuminata patients with HIV was significantly lower than those of without HIV infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of Plasma Zinc Levels Among HIV+ and HIV- Subjects Infected with Condyloma Acuminata

Wiraguna

Andriani

Adiguna

2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

“…However, given that the long median time of recurrence (over 3 years), recurrence of anal CA may be due to a new infection, recurrence at the same site, or development of a metachronous lesion. In HIV-1-infected patients it is common to have a multiple infections with several HPV types including high-risk types that is independent of immune status [ 23 , 24 ]. In our study, a 70% of patients were infected by HPV-16 or HPV-18.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men

et al. 2018

View full text Add to dashboard Cite

BackgroundThere is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men.AimTo provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors’ practice.MethodsSingle-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Standard treatments were offered: electrosurgery excision, infrared coagulation and topical imiquimod. Effectiveness was evaluated by the recurrence rate at 1 year after treatment. Recurrence was defined as any anal condyloma acuminata diagnosed after 3 months of condyloma-free survival post-treatment. Anal cytology and human-papillomavirus-infection (HPV) was assessed.ResultsBetween January 2005 and May 2009, 101 men were treated for anal condyloma acuminata: 65 (64%) with electrosurgery, 27 (27%) with infrared coagulation and 9 (9%) with imiquimod. At 1 year after treatment, the cumulative recurrence rate was 8% (4/65, 95%CI: 2–15%) with electrosurgery excision, 11% (3/27, 95%CI: 4–28%) with infrared coagulation and 11% (1/9, 95%CI: 2–44%) with imiquimod treatment. No predictive factors were associated with recurrence.Anal HPV-6 or HPV-11 was detectable in 98 (97%) patients and all had high-risk HPV genotypes, and 89 (88%) patients had abnormal anal canal cytology. Limitations: this was a retrospective descriptive analysis; limited to a single center; it cannot know if the recurrence is related to new infection.ConclusionRecurrence of anal condyloma after any treatment was common. Abnormal anal cytology and high-risk HPV-infection were highly prevalent in this population, therefore at high-risk of anal cancer, and warrants careful follow-up.

show abstract

“…The cutoff level used in this study was 350, because at the level below patients are more prone to be infected with opportunistic microorganisms. 13 Negative sexual behavior defined as those having more than one sexual partner, homosexual or bisexual, and other deviations in addition to no protection was used during sexual activity. In the study, it was no significant correlation with CA recurrence (p = 0.203).…”

Section: Discussionmentioning

confidence: 99%

Perianal Condyloma Acuminata: Factors that Contribute to the Recurrence

Jeo

Sugiharto

Kekalih

2018

NRJS

View full text Add to dashboard Cite

Introduction. Condyloma Acuminata (CA) is the most common sexually transmitted disease caused by HPV with high recurrence rate up to 70%. Factors contribute to the recurrence such as age, site of predilection, previous treatment, HIV infection and sexual behavior were noted in perianal CA. To date the correlation of these factors to the recurrence remains unknown. Method. A cross sectional study was conducted. Patients with history of CA managed in clinic of surgery during period of January 2010 to June 2015 were reviewed. Subject characteristics, i.e. age, infected site, previous treatment, HIV infection and sexual behavior and recurrence were the variables of the study. Data collected from medical record were statistically analyzed. Significant correlation found if p value <0.05. Results. There were 48 subjects with the history of CA. On the analysis, age variable has a significant correlation with the recurrence p = 0.008 (OR = 5.83; 95% CI 1.66-20.56;). The recurrence was higher in productive age compared to non-productive age. Previous anal CA and high risk negative sexual behavior showed a higher recurrence risk than previous non-anal CA and positive sexual behavior (OR = 1.89 and 2.14, respectively). Conclusion. There was significant correlation between age and CA recurrence, anal CA and negative sexual behavior showing 1.89 and 2.14 times, respectively more likely to have recurrence (New Ropanasuri J Surg.2018;3(2):e218).

show abstract

Association of Immune Status with Recurrent Anal Condylomata in Human Immunodeficiency Virus-Positive Patients

Cited by 7 publications

References 15 publications

Comparison of Plasma Zinc Levels Among HIV+ and HIV- Subjects Infected with Condyloma Acuminata

Comparison of Plasma Zinc Levels Among HIV+ and HIV- Subjects Infected with Condyloma Acuminata

Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men

Perianal Condyloma Acuminata: Factors that Contribute to the Recurrence

Contact Info

Product

Resources

About