Association of intercellular adhesion molecule 1 polymorphisms with retinopathy in Chinese patients with Type 2 diabetes

Liu, L.; Yu, Qinghua; Wang, H.; Zhang, S. X.; Huang, Chao; Chen, X.

doi:10.1111/j.1464-5491.2006.01884.x

Cited by 25 publications

(15 citation statements)

References 27 publications

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“…The primers for selected SNPs and their corresponding genes are listed (Table S1, Additional File 1). The primers were designed for each SNP using Primer III, http://frodo.wi.mit.edu/, except for a subset of SNPs (-374 T/A,-429 T/C and rs2070600 in RAGE , rs35839483 in ALR , rs5498 in ICAM-1 , rs1136287, rs58697961, rs12150053 and rs12948385 in PEDF and rs1617640 in EPO ) for which the primers were chosen from previous studies [12,14,15,23,41]. …”

Section: Methodsmentioning

confidence: 99%

Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy

et al. 2010

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BackgroundDiabetic retinopathy (DR) is classically defined as a microvasculopathy that primarily affects the small blood vessels of the inner retina as a complication of diabetes mellitus (DM).It is a multifactorial disease with a strong genetic component. The aim of this study is to investigate the association of a set of nine candidate genes with the development of diabetic retinopathy in a South Indian cohort who have type 2 diabetes mellitus (T2DM).MethodsSeven candidate genes (RAGE, PEDF, AKR1B1, EPO, HTRA1, ICAM and HFE) were chosen based on reported association with DR in the literature. Two more, CFH and ARMS2, were chosen based on their roles in biological pathways previously implicated in DR. Fourteen single nucleotide polymorphisms (SNPs) and one dinucleotide repeat polymorphism, previously reported to show association with DR or other related diseases, were genotyped in 345 DR and 356 diabetic patients without retinopathy (DNR). The genes which showed positive association in this screening set were tested further in additional sets of 100 DR and 90 DNR additional patients from the Aravind Eye Hospital. Those which showed association in the secondary screen were subjected to a combined analysis with the 100 DR and 100 DNR subjects previously recruited and genotyped through the Sankara Nethralaya Hospital, India. Genotypes were evaluated using a combination of direct sequencing, TaqMan SNP genotyping, RFLP analysis, and SNaPshot PCR assays. Chi-square and Fisher exact tests were used to analyze the genotype and allele frequencies.ResultsAmong the nine loci (15 polymorphisms) screened, SNP rs2070600 (G82S) in the RAGE gene, showed significant association with DR (allelic P = 0.016, dominant model P = 0.012), compared to DNR. SNP rs2070600 further showed significant association with DR in the confirmation cohort (P = 0.035, dominant model P = 0.032). Combining the two cohorts gave an allelic P < 0.003 and dominant P = 0.0013). Combined analysis with the Sankara Nethralaya cohort gave an allelic P = 0.0003 and dominant P = 0.00011 with an OR = 0.49 (0.34 - 0.70) for the minor allele. In HTRA1, rs11200638 (G>A), showed marginal significance with DR (P = 0.055) while rs10490924 in LOC387715 gave a P = 0.07. No statistical significance was observed for SNPs in the other 7 genes studied.ConclusionsThis study confirms significant association of one polymorphism only (rs2070600 in RAGE) with DR in an Indian population which had T2DM.

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Section: Methodsmentioning

confidence: 99%

Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy

et al. 2010

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“…However, no association of G241R in the ICAM1 gene with T1DM and DN in Swedish and GoKinD populations was found (Ma et al, 2008). In patients with T2D, the K469E polymorphism in the ICAM1 gene was found to associate with plasma fibrinogen levels and diabetic retinopathy (Kamiuchi et al, 2002; Yokoyama et al, 2005; Liu et al, 2006; Petrovic et al, 2008; Vinita et al, 2012). Up to date, there is, however, no report regarding the association of ICAM1 genetic polymorphism with DN in T2D.…”

Section: Association Of the Icam1 Genetic Polymorphisms With Diabetesmentioning

confidence: 99%

Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy

Gu¹,

Ma²,

Gu³

et al. 2013

Front. Endocrin.

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Diabetes and diabetic nephropathy are complex diseases affected by genetic and environmental factors. Identification of the susceptibility genes and investigation of their roles may provide useful information for better understanding of the pathogenesis and for developing novel therapeutic approaches. Intercellular adhesion molecule 1 (ICAM1) is a cell surface glycoprotein expressed on endothelial cells and leukocytes in the immune system. The ICAM1 gene is located on chromosome 19p13 within the linkage region of diabetes. In the recent years, accumulating reports have implicated that genetic polymorphisms in the ICAM1 gene are associated with diabetes and diabetic nephropathy. Serum ICAM1 levels in diabetes patients and the icam1 gene expression in kidney tissues of diabetic animals are increased compared to the controls. Therefore, ICAM1 may play a role in the development of diabetes and diabetic nephropathy. In this review, we present genomic structure, variation, and regulation of the ICAM1 gene, summarized genetic and biological studies of this gene in diabetes and diabetic nephropathy and discussed about the potential application using ICAM1 as a biomarker and target for prediction and treatment of diabetes and diabetic nephropathy.

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“…Although several studies investigated the association between ICAM-1 gene K469E polymorphism and DMI, their results remain inconsistent [23], [24], [25], [26], [27], [28], [29]. Considering a single study may lack the power to provide dependable conclusion, we carried out a meta-analysis to evaluate the precise effect of K469E polymorphism in ICAM-1 gene on risk of DMI including DN and DR.…”

Section: Introductionmentioning

confidence: 99%

Intracellular Adhesion Molecule-1 K469E Gene Polymorphism and Risk of Diabetic Microvascular Complications: A Meta-Analysis

Chen

Liu

et al. 2013

PLoS ONE

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BackgroundA number of studies evaluated the association of intracellular adhesion molecule-1 (ICAM-1) K469E (rs5498, A/G) gene polymorphism with diabetic microvascular complications (DMI) including diabetic nephropathy (DN) and diabetic retinopathy (DR) in different populations. However, the results of individual studies remain conflicting.MethodsA comprehensive search was conducted to identify all eligible studies of the above-mentioned associations. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were assessed using the fixed or random effect model.ResultsSeven studies involving 3411 subjects were included. Overall, the meta-analysis showed a significant association of the A allele with increased risk of DMI susceptibility in a recessive model (OR = 1.37, 95% CI 1.04–1.80, P = 0.02). In the subgroup analysis stratified by ethnicity, significant association was found in Asians but not in Caucasians (OR = 1.78, 95% CI 1.13–2.81, P = 0.01; OR = 1.10, 95% CI 0.79–1.54, P = 0.58, respectively). Moreover, it showed a significant association between the A allele and risk of DN in a recessive model (OR = 1.25, 95% CI 1.02–1.55, P = 0.04).ConclusionsThis meta-analysis suggested that the K469E polymorphism in ICAM-1 gene might affect individual susceptibility to DMI and showed a discrepancy in different ethnicities. Further investigations are needed to validate the association.

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Association of intercellular adhesion molecule 1 polymorphisms with retinopathy in Chinese patients with Type 2 diabetes

Abstract: The ICAM-1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. Patients with the K469K genotype were more likely to have diabetic retinopathy than patients with the K469E or E469E genotype.

Cited by 25 publications

References 27 publications

Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy

Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy

Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy

Intracellular Adhesion Molecule-1 K469E Gene Polymorphism and Risk of Diabetic Microvascular Complications: A Meta-Analysis

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