Association of interleukin-22 polymorphisms with the colon cancer: A case-control study

Lin, Lin; Xu, Weili; Zhang, Guojian; Ren, Pinyi; Zhao, Jing; Qiu, Yan

doi:10.1016/j.imlet.2017.06.007

Cited by 10 publications

(7 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, a total four polymorphisms in seven studies were included . Among the seven articles, three articles investigated the gastric cancer, one investigated bladder cancer, two investigated colon cancer, and one investigated the thyroid cancer . Table shows the characteristics of included studies and Table shows the genotype distribution of included studies.…”

Section: Resultsmentioning

confidence: 99%

Four polymorphisms in the IL‐22 gene and the risk of cancer: A meta‐analysis

Zhang

Zhao

et al. 2018

J Evidence Based Medicine

View full text Add to dashboard Cite

Objective: IL-22 plays an important role in cancer carcinogenesis. However, the association between IL-22 polymorphisms and cancer risk was inconclusive. The objective of the current study was to assess these associations by meta-analysis.Methods: PubMed, EMbase, CNKI, VIP, and Wanfang databases were searched up to 31 January 2018. The results were screened according to the inclusion and exclusion criteria. The associations between polymorphisms and cancer risk were estimated by meta-analysis. All analyses were performed using the Revman5.3 software. Results:A total of four polymorphisms (rs2227485, rs1179251, rs1179246, and rs1182844) in seven studies were included. The results of meta-analysis indicated that the rs1179251 polymorphism [OR = 1.46, 95% CI (1.17, 1.82), P = 0.0008 for GG+GC vs. CC] was associated with increased risk of cancer, while the rs2227485, rs1179246, and rs1182844 polymorphisms were not associated with cancer risk. Conclusions:The current meta-analysis suggests that IL-22 gene rs1179251 polymorphism may be a risk factor for cancer. K E Y W O R D Scancer, IL-22, meta-analysis, polymorphism

show abstract

Section: Resultsmentioning

confidence: 99%

Four polymorphisms in the IL‐22 gene and the risk of cancer: A meta‐analysis

Zhang

Zhao

et al. 2018

J Evidence Based Medicine

View full text Add to dashboard Cite

show abstract

“…These findings have implications for the development of IL-22 targeting therapies for human diseases. Indeed, IL-22 SNPs have been implicated in colorectal cancer (Lin et al, 2017; Thompson et al, 2010), although the mechanism of how these SNPs lead to disease is unresolved, and thus a protective or pathogenic role cannot be established. Taken together, a picture emerges in which IL-22 initially acts to suppress tumor initiation, whereas it can potentially promote tumor growth in established disease (Fig.…”

Section: Cancermentioning

confidence: 99%

The role of IL-22 in intestinal health and disease

Keir¹,

Yi²,

Lu³

et al. 2020

Journal of Experimental Medicine

291

160

View full text Add to dashboard Cite

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. In this review, we focus specifically on the role of IL-22 in the intestinal epithelium. We summarize recent advances in our understanding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and cancer.

show abstract

“…24 We noted that data from previous studies in different ethnic populations are inconsistent with our results. Lin et al 16 found that CRC cases had a significantly frequency of the IL-22 (rs2227485) TT genotype and T allele compared to the controls when stratifying by the differentiation of CRC in a Chinese population. This suggests that the distribution of the IL-22 gene frequencies vary between different ethnic groups.…”

Section: Genotypementioning

confidence: 99%

“…12 Additionally, relationships between polymorphisms and cytokine levels, including those of TGFβ1 and IL-10, -22, and -27, have been reported in CRC patients. [14][15][16][17] However, the effects of these cytokine gene polymorphisms on CRC patients in Saudi Arabia are understudied. The present study aims to explore how CRC patients in Saudi Arabia are affected by the presence of several specific cytokine polymorphisms: IL-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and TGFß1 (rs1800469 C/T).…”

mentioning

confidence: 99%

A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer

Althubyani

Alkhuriji

Alomar

et al. 2020

SMJ

View full text Add to dashboard Cite

IL-27)rs17855750T / G) ‫أليل‪G‬‬ ‫و‬ G ‫1529711‪))rs‬أليل‬ C/G ‫اجلينية‬ ‫األمناط‬ ‫كان‬ ‫قيما‬ CT,TT)TGFß1)rs1800469 C / T‫و‬ IL-10)rs1800896 A/G) ‫و‬ TGFß1)rs1800469 C/T)CC ‫ـ‬ ‫ل‬ ‫اجليني‬ ‫األشكال‬ ‫تعدد‬ ‫بني‬ ‫ارتباطات‬ ‫حتدد‬ ‫لم‬ ‫باملرض.‬ ‫لإلصابة‬ ‫محفزا‬ AA ‫سرطان‬ ‫وخطر‬ IL-22)rs2227485 C/T) ‫و‬)IL-8)rs4073 T/A ‫واملستقيم.‬ ‫القولون‬ IL-10)rs1800896 ‫األشكال‬ ‫ـتعدد‬ ‫ل‬ ‫الكبير‬ ‫لتأثير‬ ‫النتائج‬ ‫تشير‬ ‫اخلالصة:‬)IL-27)rs17855750 T/G ‫و‬)IL-22)rs1179251 C/G ‫و‬)A/G ‫لم‬ ‫واملستقيم؛‬ ‫القولون‬ ‫سرطان‬ ‫خطر‬ ‫على‬ TGFß1)rs1800469 C/T) ‫و‬ IL-22)rs2227485)‫و‬)IL-8)rs4073T/A ‫األشكال‬ ‫تعدد‬ ‫يترافق‬ ‫واملستقيم.‬ ‫القولون‬ ‫سرطان‬ ‫خطر‬ ‫مع‬ C/T Objectives: To determine the possible associations of polymorphisms in interleukin (IL)-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and transforming growth factor beta 1 (TGFß1) (rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients. Methods: The case-control study was carried out between July 2019 and January 2020 in King Khaled University Hospital, Riyadh, Saudi Arabia. A total of 70 patients with CRC and 70 healthy controls were included in the study. Single nucleotide polymorphisms Original Article of promoter regions were determined using TaqMan genotyping assays. Results: A statistically significant reduction in CRC risk was identified for carriers of the IL-10 (rs1800896 A/G) AG genotype, IL-22 (rs1179251 C/G) G allele, IL-27 (rs17855750 T/G) G allele and TGFß1 (rs1800469 C/T) CT and TT genotype. While IL-10 (rs1800896 A/G) AA genotype and TGFß1 (rs1800469 C/T) CC genotype were significantly associated with increased susceptibility to CRC. No significant associations were identified between the cytokine polymorphisms of IL-8 (rs4073 T/A) and IL-22 (rs2227485 C/T), and CRC risk. Conclusion: Our findings indicate a significant impact of IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G), IL-27 (rs17855750 T/G) and TGF-ß1 (rs1800469 C/T) polymorphisms on risk of CRC; while the IL-8 (rs4073 T/A) and IL-22 (rs2227485 C/T) and polymorphisms were not associated with CRC risk.

show abstract

Association of interleukin-22 polymorphisms with the colon cancer: A case-control study

Cited by 10 publications

References 37 publications

Four polymorphisms in the IL‐22 gene and the risk of cancer: A meta‐analysis

Four polymorphisms in the IL‐22 gene and the risk of cancer: A meta‐analysis

The role of IL-22 in intestinal health and disease

A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer

Contact Info

Product

Resources

About