Association of intracortical myelin and cognitive function in bipolar I disorder

Sehmbi, Manpreet; Rowley, Christopher D.; Minuzzi, Luciano; Kapczinski, Flávio; Steiner, Meir; Sassi, Roberto; Bock, Nicholas A.; Frey, Benício N.

doi:10.1111/acps.12875

Cited by 16 publications

(19 citation statements)

References 39 publications

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“…Exploring whether increased ICM in PCC in people with AUD is related to neurocognitive performance is an important next step. Differences in DLPFC / Brodmann Area 46 have also been reported in previous studies with patients with bipolar disorder [25].…”

Section: Discussionsupporting

confidence: 81%

“…Prior studies with clinical samples have also indicated significant ICM disruption in people with bipolar disorder [16,24,25], schizophrenia [31,32], and other major mental health disorders [47].…”

Section: Discussionmentioning

confidence: 99%

“…All images were acquired with 1mm isotropic resolution using a scan protocol developed by Bock and colleagues [21] and used in several prior studies of ICM [16,24,25]. Full details of the MRI scanning protocol are provided in Supplementary Materials.…”

Section: Image Acquisitionmentioning

confidence: 99%

“…The MRI protocol developed by Bock et al has been used in multiple studies of ICM in healthy [16,24] and clinical populations [16,24,25]. For example, it has been suggested that disruptions in ICM may partially underlie susceptibility to the development of mental health disorders such as bipolar disorder and schizophrenia [11].…”

Section: Introductionmentioning

confidence: 99%

“…Additional research examining white matter in bipolar disorder has found that patients have fewer oligodendrocytes, reduced myelin-related genes, and significant age-related deficits in ICM development [27][28][29][30]. Moreover, impairments in neurocognitive performance (i.e., verbal memory) have been associated with ICM in patients with bipolar disorder [25]. In the context of schizophrenia, ICM has been shown dysregulated in the frontal lobes [31].…”

Section: Introductionmentioning

confidence: 99%

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An Initial Investigation of Disrupted Intracortical Myelin as a Novel Brain Marker of Alcohol Use Disorder

Morris¹,

Minuzzi²,

Bock³

et al. 2020

Preprint

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Although disruption of cortical gray matter and white matter tracts are well-established markers of alcohol use disorder (AUD), this is the first study to examine the specific role of intracortical myelin (ICM; i.e., highly myelinated gray matter in deeper cortical layers) in AUD. The current study used a 3T MRI sequence optimized for high intracortical contrast to examine patterns of ICM-related MRI signal in 30 individuals with AUD and 33 healthy social drinkers. Secondary aims included exploring continuous associations with alcohol problem severity and examining sex differences. Surface-based analytic techniques were used to quantify ICM-related MRI signal for a priori region of interest analyses (20 bilateral regions) and exploratory vertex-wise analyses (using Cohen’s d). Although the distribution of ICM-related signal was generally comparable between groups, the AUD group exhibited significantly (p<.05) greater ICM-related MRI signal in precuneus, ventromedial prefrontal cortex, posterior cingulate, middle anterior cingulate, middle/posterior insula, dorsolateral prefrontal cortex, and posterior cingulate, among other regions (Cohen’s d = .50-.75, indicating medium magnitude effects). Significant positive correlations between ICM signal and AUD severity were found in several frontal, parietal, cingulate, and temporal regions (rs .25-.34). No sex differences in ICM were observed. These findings provide initial proof-of-concept for examining ICM in relation to AUD. Understanding the pathophysiological mechanisms of these associations (e.g., neuroinflammation) and the clinical relevance of ICM is warranted.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Image Acquisitionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Initial Investigation of Disrupted Intracortical Myelin as a Novel Brain Marker of Alcohol Use Disorder

Morris¹,

Minuzzi²,

Bock³

et al. 2020

Preprint

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Intracortical myelin in individuals with alcohol use disorder: An initial proof‐of‐concept study

et al. 2022

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Introduction Disruption of cortical gray matter and white matter tracts are well‐established markers of alcohol use disorder (AUD), but less is known about whether similar differences are present in intracortical myelin (ICM, i.e., highly myelinated gray matter in deeper cortical layers). The goal of this study was to provide initial proof‐of‐concept for using an optimized structural magnetic resonance imaging (MRI) sequence to detect differences in ICM in individuals with AUD compared to control participants reporting drinking within recommended guidelines. Methods This study used an optimized 3T MRI sequence for high intracortical contrast to examine ICM‐related MRI signal in 30 individuals with AUD and 33 healthy social drinkers. Surface‐based analytic techniques were used to quantify ICM‐related MRI signal in 20 bilateral a priori regions of interest based on prior cortical thickness studies, and exploratory vertex‐wise analyses were examined using Cohen's d effect size. Results The global distribution of ICM‐related signal was largely comparable between groups. Region of interest analysis indicated that AUD group exhibited greater ICM‐related MRI signal in precuneus, ventromedial prefrontal cortex, posterior cingulate, middle anterior cingulate, middle/posterior insula, and dorsolateral prefrontal cortex (Cohen's d s = 0.50–0.75). Four regions (right precuneus, ventromedial prefrontal cortex, posterior cingulate and left dorsolateral prefrontal cortex) remained significant ( p < .05) after covarying for smoking status. Conclusion These findings provide initial evidence of ICM differences in a moderately sized sample of individuals with AUD compared to controls, although the inflation of type 1 error rate necessitates caution in drawing conclusions. Robustly establishing these differences in larger samples is necessary. The cross‐sectional design cannot address whether the observed differences predate AUD or are consequences of heavy alcohol consumption.

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Structural and Functional Brain Correlates of Neuroprogression in Bipolar Disorder

Librenza-Garcia

Suh

Watts

et al. 2020

Current Topics in Behavioral Neurosciences

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Association of intracortical myelin and cognitive function in bipolar I disorder

Cited by 16 publications

References 39 publications

An Initial Investigation of Disrupted Intracortical Myelin as a Novel Brain Marker of Alcohol Use Disorder

An Initial Investigation of Disrupted Intracortical Myelin as a Novel Brain Marker of Alcohol Use Disorder

Intracortical myelin in individuals with alcohol use disorder: An initial proof‐of‐concept study

Structural and Functional Brain Correlates of Neuroprogression in Bipolar Disorder

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