Association of KCNQ1 gene polymorphism with gestational diabetes mellitus in a Chinese population

Zhou, Qi; Zhang, K.; Li, W.; Liu, J. T.; Hong, Jing; Qin, Shukui; Ping, Fan; Sun, Miao; Nie, Min

doi:10.1007/s00125-009-1500-y

Cited by 26 publications

(27 citation statements)

References 7 publications

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“…While we were preparing this paper, two similar reports regarding KCNQ1 and GDM were published [25,26]. The report of Shin et al [25] used our allele frequency data of the control subjects that was previously published [1].…”

Section: Discussionmentioning

confidence: 95%

Polymorphisms in <i>KCNQ1</i> Are Associated with Gestational Diabetes in a Korean Population

Kwak

Kim²,

Cho³

et al. 2010

Horm Res Paediatr

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Background: Recent genome-wide association studies in East Asians have identified polymorphisms in KCNQ1 as new type 2 diabetes risk variants. The aim of this study was to investigate whether variants in KCNQ1 are associated with development of gestational diabetes mellitus (GDM) and measures of oral glucose tolerance test (OGTT) at the time of diagnosis of GDM. Methods: Three candidate single nucleotide polymorphisms (rs2074196, rs2237892, and rs2237895) were genotyped in 869 Korean GDM women and 632 nondiabetic control subjects. Insulin resistance was estimated by homeostasis model assessment and pancreatic β-cell function by the insulinogenic index at 1 h. Results: rs2074196 and rs2237892 were associated with the risk of GDM (OR 1.17, 95% CI 1.01–1.36, p = 0.039; OR 1.24, 95% CI 1.07–1.45, p = 0.0049). Furthermore, rs2237892 and rs2237895 were nominally associated with a decreased insulinogenic index at the time of GDM diagnosis (p = 0.025 and p = 0.037), whereas no association was observed with measures of insulin resistance. Conclusions: The single nucleotide polymorphisms in KCNQ1 showed a significant association with GDM in the Korean population. Although the mechanism is not yet clear, it could be possible that variants in KCNQ1 confer a risk for GDM by altering pancreatic β-cell function.

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Section: Discussionmentioning

confidence: 95%

Polymorphisms in <i>KCNQ1</i> Are Associated with Gestational Diabetes in a Korean Population

Kwak

Kim²,

Cho³

et al. 2010

Horm Res Paediatr

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“…The number of women with GDM included in these studies ranged greatly from 25 (Low, Mohd Tohit, Chong, & Idris, 2010) to 930 (Shin et al, 2010). Sample size powered at least 80% was reported in only 6 of 24 studies (King, 2007;Lauenborg et al, 2009;Pappa et al, 2011;Shaat et al, 2005;Zhou et al, 2009). Most studies compared genetic variants between pregnant women with GDM (cases) and pregnant women with normoglycemia (controls).…”

Section: Resultsmentioning

confidence: 96%

“…The C allele of the rs2237892 was associated with GDM in two Korean studies (Kwak et al, 2010;Shin et al, 2010) but not in the Chinese study (Zhou et al, 2009). Instead, rs2237896 and rs2237895 were associated with GDM in a Chinese population (Zhou et al, 2009). Both rs2237892 and rs2237895 were associated with decreased insulin secretion but not with insulin resistance, indicating KCNQ1 conferring a risk for GDM by altering pancreatic beta cell function (Kwak et al, 2010).…”

Section: Kcnq1mentioning

confidence: 94%

Section: Kcnq1mentioning

confidence: 94%

“…Three studies have investigated association between KCNQ1 gene and GDM in Koreans (Kwak et al, 2010;Shin et al, 2010) and in Chinese (Zhou et al, 2009). The C allele of the rs2237892 was associated with GDM in two Korean studies (Kwak et al, 2010;Shin et al, 2010) but not in the Chinese study (Zhou et al, 2009).…”

Section: Kcnq1mentioning

confidence: 98%

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Shared Genomics of Type 2 and Gestational Diabetes Mellitus

Wung

Lin²

2011

Annu Rev Nurs Res

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Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and the prevalence of GDM is increasing worldwide. Short- and long-term complications of GDM on mothers and fetuses are well-recognized. These include more than seven-fold higher risk for type 2 diabetes mellitus (T2DM) later in life in women with GDM than those without. Evidence supports that GDM shares several risk factors with T2DM, including genetic risks. This chapter reviewed studies on candidate genes shared by T2DM and GDM published from 1990 to 2011. At least 20 susceptible genes of T2DM have been studied in women with GDM in various races. Results from current association studies on T2DM susceptible genes in GDM have shown significant heterogeneity There may be primary evidence that polymorphisms of susceptible genes of T2DM such as transcription factor 7-like 2 (TCF7L2) gene, potassium channel voltage-gate KQT-like subfamily member 1 (KCNQ1) gene, and cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) gene, may increase risk of GDM. Associations between GDM and many genetic variants have led to different findings across populations. Many genetic polymorphisms related to GDM were investigated in a single study or a single population. Replication studies to verify contributions of both common and rare genetic variants for GDM and T2DM in specific racial/ethnic groups are needed.

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KCNE Regulation of KCNQ Channels

Abbott

2020

Studies of Epithelial Transporters and Ion Channels

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Association of KCNQ1 gene polymorphism with gestational diabetes mellitus in a Chinese population

Cited by 26 publications

References 7 publications

Polymorphisms in <i>KCNQ1</i> Are Associated with Gestational Diabetes in a Korean Population

Polymorphisms in <i>KCNQ1</i> Are Associated with Gestational Diabetes in a Korean Population

Shared Genomics of Type 2 and Gestational Diabetes Mellitus

KCNE Regulation of KCNQ Channels

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