2022
DOI: 10.3389/fsurg.2022.905575
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Association of Ki-67 Change Pattern After Core Needle Biopsy and Prognosis in HR+/HER2− Early Breast Cancer Patients

Abstract: BackgroundTo investigate the association of Ki-67 change pattern after core needle biopsy (CNB) and prognosis in HR+/HER2− early breast cancer patients.MethodEligible patients were categorized into three groups: Low group, Elevation group, and High group. Chi-square test and logistic regression analysis were used to compare the clinic-pathological characteristics. Kaplan–Meier method was used to estimate the rates of recurrence-free interval (RFI) and breast cancer-specific survival (BCSS), which were compared… Show more

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“…High Ki67 expression implies active cell proliferation; the Ki67 index can reflect the proliferation capacity of tumor cells [ 6 , 7 ]. High Ki67 expression in PCa is a poor prognostic factor and is correlated with overall survival, disease-free survival, and distant metastasis [ 8 , 9 ]. The existing methods for detecting Ki67 expression levels are invasive, complex, barely reproducible, and susceptible to subjective influence [ 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…High Ki67 expression implies active cell proliferation; the Ki67 index can reflect the proliferation capacity of tumor cells [ 6 , 7 ]. High Ki67 expression in PCa is a poor prognostic factor and is correlated with overall survival, disease-free survival, and distant metastasis [ 8 , 9 ]. The existing methods for detecting Ki67 expression levels are invasive, complex, barely reproducible, and susceptible to subjective influence [ 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%