Association of KIR genes and their HLA ligands diversity with colorectal cancer in Lur population of Iran

Shayanrad, Bahareh; Ghanadi, Koroush; Varzi, Ali-Mohammad; Birjandi, Mehdi; Ahmadi, Seyyed Amir Yasin; Shahsavar, Farhad

doi:10.1016/j.mgene.2019.100603

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Genomic DNA of the participants was extracted from the white blood cells of peripheral blood samples. A total of 100 healthy controls were selected from a previous study by Shahsavar et al (36). All controls were of Lur heritage and have lived in Lorestan.…”

Section: Design and Patientsmentioning

confidence: 99%

Rheumatoid arthritis is associated with KIR2DS4-full among the KIR genes in Lur Population of Iran

et al. 2021

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Background:The pathophysiology underlying the progression and development of autoimmune conditions, such as Rheumatoid Arthritis (RA), is a result of dysregulations of the immune system. Research has explored the genetic alterations present in RA; however, limited studies have examined the role of Killer cell Immunoglobulin-like Receptors (KIR) and Human Leukocyte Antigen (HLA) molecules in RA. Therefore, the aim of this study was to examine KIR genes, their HLA ligands, and KIR-HLA compounds in patients with RA. Methods: In this case-control study, a total of 50 patients with RA and 100 healthy individuals were enrolled. DNA samples were evaluated using PCR with sequence specific Primers (PCR-SSP). Odds ratio (OR) with a 95% confidence interval (CI) were reported. Results: Among the KIR genes examined, KIR2DLA (p= 0.0255, OR= 0.389, 95% CI= 0.210-0.722) and KIR2DS4-full (p< 0.0001, OR= 6.163, 95% CI= 3.174-11.968) were observed to have a statistically significant correlation with disease susceptibility to RA. As an inhibitory gene, KIR2DLA was observed to have a protective effect against RA while KIR2DS4-full as an activating gene, was found to increase risk for RA. No significant associations were found between any of the other KIR genotypes, HLA ligands, or KIR-HLA compounds examined in this study to RA susceptibility. Conclusions: In this study of RA in the Lur population of Iran, KIR2DS4-full was observed to increase susceptibility to RA, while KIR2DL5A was found to act as a protecting factor based on both the cross Table and regression analyses. Further research should focus on repeating this study in additional populations.

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Section: Design and Patientsmentioning

confidence: 99%

Rheumatoid arthritis is associated with KIR2DS4-full among the KIR genes in Lur Population of Iran

et al. 2021

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“…These patients can be treated by the monoclonal antibodies even in malignant conditions [23,27]. In addition to the cell cycle related genes, genetic diversity of the genes like human leukocyte antigens (HLA) and killer-cell immunoglobulin-like receptors (KIR) which are highly polymorphic, can be effective on susceptibility to or resistance against this cancer [28,29].…”

Section: Introductionmentioning

confidence: 99%

Investigation of breast cancer screening among the women of Khorramabad (west of Iran): A cross-sectional study

Anbari

Ahmadi

Sahraei

et al. 2022

ebph

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Abstract. Breast cancer is the most common women's cancer that more than 90% of the patients can be treated or even cured through early diagnosis. So we intend to investigate the status of breast cancer screening in Khorramabad, a city in the west of Iran. In the present cross-sectional study, the study population included 457 number of 20 to 65 year old women referring to the health centers of Khorramabad during the second half of 2015 to receive health care services. The sampling method was multistage random-cluster. A multi-part questionnaire were used. Fisher exact test, chi-square and independent t tests were used to analyze the data. The regular self-breast exam (SBE) had been carried out by 12.3% of the women, visiting doctors for regular clinical breast exam (CBE) had been done by 6% of the respondents and regular mammography every one to two years had been performed by 2.4% of the women. A statistically significant relationship was seen between occupation (P = 0.001), regular consumption of contraceptive pills (P = 0.032), history of breastfeeding, history of breast cancer in the first degree relatives (P = 0.001), and a history of cancer in the second degree (P = 0.005) relatives, and the regular SBE. Planning to enhance the women's awareness about breast cancer and the methods of early diagnosis and designing educational programs can be an important step to reduce deaths and disabilities caused by this disease among the women in such deprived cities.

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Association of KIR genes and their HLA ligands diversity with colorectal cancer in Lur population of Iran

Cited by 2 publications

References 17 publications

Rheumatoid arthritis is associated with KIR2DS4-full among the KIR genes in Lur Population of Iran

Rheumatoid arthritis is associated with KIR2DS4-full among the KIR genes in Lur Population of Iran

Investigation of breast cancer screening among the women of Khorramabad (west of Iran): A cross-sectional study

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