2022
DOI: 10.18413/2658-6533-2020-6-3-0-3
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Association of L432V (rs1056836) polymorphism of the CYP1B1 gene with the increased risk of colorectal cancer in the population of Central Russia

Abstract: Background: Colon malignancies are one of the most common worldwide. Different pro-carcinogenic agents such as polycyclic aromatic hydrocarbons (PAH) and heterocyclic aromatic amines can potentially play a key role in the malignant transformation of cells by interacting with DNA. The enzyme of the 1 st phase of xenobiotic biotransformation CYP1B1 is involved in the metabolic activation of various carcinogens. The aim of the study: The aim of our study was to investigate the association between common SNP rs105… Show more

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“…Histological types of colorectal cancer in the case group included well-differentiated adenocarcinoma (70.3% of cases), moderately differentiated adenocarcinoma (21.6% of cases), and poorly differentiated adenocarcinoma (8.1% of cases). The control group was recruited from the same population and included healthy blood volunteers and hospital-based patients with no clinical evidence for CRC, as described previously [22,23]. The criterion for inclusion in the control group was the absence of oncological and other chronic diseases.…”
Section: Study Participantsmentioning
confidence: 99%
“…Histological types of colorectal cancer in the case group included well-differentiated adenocarcinoma (70.3% of cases), moderately differentiated adenocarcinoma (21.6% of cases), and poorly differentiated adenocarcinoma (8.1% of cases). The control group was recruited from the same population and included healthy blood volunteers and hospital-based patients with no clinical evidence for CRC, as described previously [22,23]. The criterion for inclusion in the control group was the absence of oncological and other chronic diseases.…”
Section: Study Participantsmentioning
confidence: 99%