Association of late‐onset neonatal sepsis with late neurodevelopment in the first two years of life of preterm infants with very low birth weight

Hentges, Cláudia Regina; Silveira, Rita C.; Procianoy, Renato Soibelmann; Carvalho, Clarissa Gutiérrez; Filipouski, Gabriela Ribeiro; Fuentefria, Rubia N.; Marquezotti, Fernanda; Terrazan, Ana C.

doi:10.1016/j.jpedp.2013.05.006

Cited by 23 publications

(47 citation statements)

References 17 publications

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“…Birth weight is a strong factor associated with the risk of sepsis in preterm infants due to the peculiar immunological immunity, being inversely proportional. (4,7,16,19) In this study, a strong association and greater risk for sepsis were found.…”

Section: Discussionsupporting

confidence: 58%

“…(18) Venous accesses stand out as HAI and associated with cases of sepsis. (4,12,(16)(17)(18) In this study, the birth weight (p= 0.03), peripheral venous access (p= 0.05) and arterial umbilical catheter (p= 0.10) showed higher significance rates with p< 0.20, being included in the logistic regression model adjusted to gesta- Adjusted model for gestational age and gender tional age and gender. In the final model, however, birth weight and arterial umbilical catheter remained as independent factors, the latter being an important determinant in the occurrence of late sepsis.…”

Section: Discussionmentioning

confidence: 59%

“…(5,7,16,17) At the NICU where the study was developed, figures for late sepsis were less expressive.…”

Section: Discussionmentioning

confidence: 99%

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A correlação entre procedimentos assistenciais invasivos e a ocorrência de sepse neonatal

et al. 2016

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Objective: To correlative the invasive care procedures applied to very-low-birth-weight infants with the occurrence of neonatal sepsis. Methods: Retrospective, longitudinal cohort study undertaken through the investigation of secondary data between 2008 and 2012. The infants' characteristics were analyzed by means of the Mann-Whitney test (means) and the chi-square test to compare frequencies. All variables with significance of p<0.20 in the bivariate analysis were included in a logistic regression model. Results: The data demonstrated fourteen infants with an episode of late sepsis. The mean gestational age was 30 weeks. Female gender and cesarean birth were the most frequent. The birth weight and the use of an arterial umbilical catheter explained the occurrence of sepsis, offering an 8.5 times higher risk for the outcome. Conclusion: Vascular accesses need start insertion and handling techniques to improve the health indicators. ResumoObjetivo: Correlacionar os procedimentos assistenciais invasivos realizados nos recém-nascidos de muito baixo peso com a ocorrência de sepse neonatal. Métodos: Estudo de coorte retrospectivo, longitudinal, por meio de pesquisa de dados secundários, durante os anos de 2008-2012. As características dos recém-nascidos foram analisadas pelo teste de Mann-Whitney (médias) e o teste do qui quadrado para comparação de frequências. Todas as variáveis com significância de p<0,20 na análise bivariada compuseram um modelo de regressão logística. Resultados: Os dados demonstraram quatorze recém-nascidos com episódio de sepse tardia. A idade gestacional média foi de trinta semanas. Gênero feminino e parto cesáreo foram os mais frequentes. O peso de nascimento e o uso do cateter umbilical arterial explicaram a ocorrência de sepse, tendo este oferecido 8,5 vezes maior risco para o desfecho. Conclusão: Acessos vasculares necessitam rigor nas técnicas de inserção e manuseio para a melhoria dos indicadores de saúde.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 59%

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A correlação entre procedimentos assistenciais invasivos e a ocorrência de sepse neonatal

et al. 2016

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“…Approximately 21–36% of very low birthweight preterm infants have LOS 56 100 102. Neurodevelopmental impairment is increased following clinical infection as well as culture-positive sepsis and meningitis when compared with infants without suspected sepsis103 and the risk is increased further in infants who have experienced both EOS and LOS as a ‘double hit’ 56…”

Section: Preventing Causative Morbiditiesmentioning

confidence: 99%

Protecting the premature brain: current evidence-based strategies for minimising perinatal brain injury in preterm infants

Lea

Smith-Collins

Luyt

2016

Arch Dis Child Fetal Neonatal Ed

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. INTRODUCTIONSurvival rates for preterm babies are increasing, 1 however severe neurological impairment remains a significant consequence of preterm birth.2 3 Research continues into potential treatments for reducing both the risk of initial brain injury and subsequent neurodevelopmental problems; 4 however, in the interim, these can be reduced by optimising currently approved and recommended practices.

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“…, Enterobacter species), group B Streptococcus (GBS), Staphylococcus aureus , ureaplasma, mycoplasma species, yeast infections ( e.g. , Candida ) (Hecht et al, 2008; Hentges et al, 2014; Stoll et al, 2004), and many viruses including herpes group B and cytomegalovirus (Nijman et al, 2013). In developed countries, low‐level infections with less pathogenic CoNS ( e.g.…”

Section: Postnatal Infection and Inflammationmentioning

confidence: 99%

Potential neuroprotective strategies for perinatal infection and inflammation

Ranchhod

Gunn

Fowke

et al. 2015

Intl J of Devlp Neuroscience

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Preterm born infants have high rates of brain injury, leading to motor and neurocognitive problems in later life. Infection and resulting inflammation of the fetus and newborn are highly associated with these disabilities. However, there are no established neuroprotective therapies. Microglial activation and expression of many cytokines play a key role in normal brain function and development, as well as being deleterious. Thus, treatment must achieve a delicate balance between possible beneficial and harmful effects. In this review, we discuss potential neuroprotective strategies targeting systemic infection or the resulting systemic and central inflammatory responses. We highlight the central importance of timing of treatment and the critical lack of studies of delayed treatment of infection/inflammation.

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Association of late‐onset neonatal sepsis with late neurodevelopment in the first two years of life of preterm infants with very low birth weight

Cited by 23 publications

References 17 publications

A correlação entre procedimentos assistenciais invasivos e a ocorrência de sepse neonatal

A correlação entre procedimentos assistenciais invasivos e a ocorrência de sepse neonatal

Protecting the premature brain: current evidence-based strategies for minimising perinatal brain injury in preterm infants

Potential neuroprotective strategies for perinatal infection and inflammation

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