Association of Left Atrial Booster‐Pump Function with Heart Failure Symptoms in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction

Imanishi, Junichi; Tanaka, Hidekazu; Sawa, Takuma; Motoji, Yoshiki; Miyoshi, Tatsuya; Mochizuki, Yasuhide; Fukuda, Yuko; Tatsumi, Kazuhiro; Matsumoto, Kensuke; Okita, Yutaka; Hirata, Ken‐ichi

doi:10.1111/echo.12733

Cited by 20 publications

(14 citation statements)

References 46 publications

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“…We found that left atrial longitudinal strain rate during atrial contraction (LAs SR) which represents the LA booster pump function was increased in LAD patients despite decrease in the left atrial longitudinal strain (PALS) which represents the LA reservoir function. Also peak atrial contraction strain (PACS) was higher in LAD patients but did not reach significant difference making LAs SR is the most accurate index for evaluating LA booster pump function and these findings are consistent with Imanishi et al 24 findings.…”

Section: Discussionsupporting

confidence: 87%

Left atrial deformation analysis as a predictor of severity of coronary artery disease

Said

Nassar

Fouad

et al. 2018

The Egyptian Heart Journal

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BackgroundTwo-dimensional (2D) speckle-tracking strain imaging is a novel method for assessment of regional myocardial deformation that uses tracking of acoustic speckles or kernels rather than Doppler myocardial velocities. It has been suggested that Left atrial (LA) strain as measured by 2D speckle tracking can be used to evaluate dynamic LA function.ObjectiveTo study the relation between left atrial deformation and the severity of coronary artery stenosis in patients with stable coronary artery disease (CAD).Study design30 patients with stable coronary artery disease (SCAD) with coronary artery stenosis (>50%) who were admitted for elective coronary angiography at Ain Shams University hospitals and AlAzhar University hospitals were included in the study. Measurements of conventional echocardiographic parameters as well as LA strain and strain rate parameters were obtained, Syntax (SX) score was calculated for all patients.ResultsPatients were categorized into 3 groups: low Syntax score of <23 (Group I), moderate syntax score 23–32 (Group II) and high syntax score of ≥33 (Group III). Peak atrial longitudinal strain (PALS) (Group I: 29.80 ± 4.48, Group II: 22.44 ± 1.42, Group III: 19.53 ± 4.46; p < 0.001) and Peak atrial contraction strain (PACS) (Group I: 13.43 ± 4.05, Group II: 10.84 ± 2.47, Group III: 7.19 ± 0.71; p < 0.022) were significantly lower in high syntax group. Significant negative correlation was found between SX score level and LA strain parameters (PALS and PACS) (r = 0.861; p < 0.001).ConclusionLeft atrial deformation analysis by 2D Speckle tracking Doppler Echocardiography can predict the severity of coronary affection in patients with stable CAD.

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Section: Discussionsupporting

confidence: 87%

Left atrial deformation analysis as a predictor of severity of coronary artery disease

Said

Nassar

Fouad

et al. 2018

The Egyptian Heart Journal

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“…Impaired LA booster pump function evaluated with strain imaging is related to the presence of heart failure symptoms in hypertrophic cardiomyopathy and aortic stenosis in humans. Whether the reduced LA booster pump function in heart failure patients results from impairment of LA intrinsic contraction or from LA afterload mismatch (elevated LV end‐diastolic pressure) remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Strain at Different Stages of Myxomatous Mitral Valve Disease in Dogs

Nakamura

Kawamoto

Osuga

et al. 2017

Veterinary Internal Medicne

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BackgroundDecreased function of the left atrium (LA) is a useful prognostic indicator in dogs with myxomatous mitral valve disease (MMVD). In humans, LA strain is a novel severity indicator of mitral regurgitation, but its clinical utility in dogs has not been confirmed.ObjectivesTo examine whether LA strain as evaluated with speckle‐tracking echocardiography is associated with MMVD stage in dogs.AnimalsFifty‐two client‐owned dogs with MMVD.MethodsCross‐sectional study. Dogs were classified as stage B1, B2, C, or D, according to the American College of Veterinary Internal Medicine consensus. Physical examination findings and echocardiographic variables were compared among the groups. To assess the comparative accuracy of echocardiographic variables in identifying dogs with the presence or history congestive heart failure (CHF), receiver operating characteristic curves and multivariate logistic analysis were used.ResultsThere were no significant differences in parameters of LA strain between B1 and B2 groups. However, LA longitudinal strain during atrial contraction (εA) (median, 19.1%; interquartile range, 15.3–24.3% in B1, 19.6%; 14.1–21.4% in B2, 6.2%; 3.18–11.2% in C/D) and during ventricular systole (εS) (32.7%; 28.9–39.2% in B1, 35.6%; 31.7–41.9% in B2, 23.6%; 16.9–26.1% in C/D) were significantly lower in stages C/D than in stages B1 and B2. In multivariate logistic regression analysis, εA and peak early diastolic mitral inflow velocity were identified as independent indicators of stage C/D.Conclusions and Clinical ImportanceεA was the best predictor of the presence or history of CHF. Further studies are needed to determine the clinical implications of these findings for treatment decisions and prognosis determination.

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“…In this study, a significant increase in the post-procedural LAA tissue Doppler velocities in the low LVEF group was detected. Different studies demonstrated depressed LA or LAA functions due to LV mass, LV outflow tract gradients, and LV diastolic dysfunction [22][23][24]. Moreover, the functions of LA booster-pump were found to be related to symptoms of severe AS in patients with preserved LVEF [22].…”

Section: Discussionmentioning

confidence: 99%

“…Different studies demonstrated depressed LA or LAA functions due to LV mass, LV outflow tract gradients, and LV diastolic dysfunction [22][23][24]. Moreover, the functions of LA booster-pump were found to be related to symptoms of severe AS in patients with preserved LVEF [22]. Although the velocities of the E/E m and E m have a close relationship with systolic function, recent studies reported that this parameter reflected the functions of the LAA, independent of the LVEF [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Short-term effects of transcatheter aortic valve implantation on left atrial appendage function

Aslan

Gül

Çakmak³

et al. 2015

Cardiol J.

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Association of Left Atrial Booster‐Pump Function with Heart Failure Symptoms in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction

Abstract: SR-LAa was found to be associated with the HF symptoms. Characterization of LA booster-pump function may be useful for the assessment of the symptomatic status in patients with severe AS patients and limited physical activity.

Cited by 20 publications

References 46 publications

Left atrial deformation analysis as a predictor of severity of coronary artery disease

Left atrial deformation analysis as a predictor of severity of coronary artery disease

Left Atrial Strain at Different Stages of Myxomatous Mitral Valve Disease in Dogs

Short-term effects of transcatheter aortic valve implantation on left atrial appendage function

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