Association of left ventricular myocardial dysfunction with diabetic polyneuropathy

Tabako, Satoshi; Harada, Masahiko; Sugiyama, Kunio; Ohara, Hiroshi; Ikeda, Takanori

doi:10.1007/s10396-018-0898-6

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…However, the latter did not investigate subclinical systolic function parameters in its group 50 . Also, DCM evaluated by 2D‐STE has been shown to precede diabetic polyneuropathy in a study conducted by Tabako et al, both systolic and diastolic functions being impaired 22 …”

Section: Resultsmentioning

confidence: 97%

“…Subclinical systolic dysfunction was predominantly assessed using 2D STE parameters: GLS was measured in most of the cases, but global circumferential (GCS) and radial (GRS) strains were also measured in some of the included studies 4,7,8,16,21‐25 (Table 1). Furthermore, few studies also used 3D STE 1,7,26 and multiple‐layer strain 5,8,21,27‐30 for systolic function assessment.…”

Section: Resultsmentioning

confidence: 99%

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Assessment of subclinical diabetic cardiomyopathy by speckle‐tracking imaging

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et al. 2021

Eur J Clin Investigation

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Background Diastolic dysfunction is traditionally believed to be the first subclinical manifestation of diabetic cardiomyopathy (DCM), leading to systolic dysfunction and then overt heart failure. However, in the last few years, several studies suggested that systolic subclinical dysfunction measured by speckle‐tracking echocardiography (STE) may appear ahead of diastolic dysfunction. In this review, the main endpoint is to show whether subclinical myocardial systolic dysfunction appears ahead of diastolic dysfunction and the implication this may have on the evolution and management of DCM. Materials and methods We performed a search in PubMed for all relevant publications on the assessment of DCM by STE from 1 June 2015 to 1 June 2020. Results and Conclusions The results illustrate that subclinical systolic dysfunction assessed by STE is present in early DCM stages, with or without the association of diastolic dysfunction. This could be a promising perspective for the early management of patients with DCM leading to the prevention of the overt form of disease.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Assessment of subclinical diabetic cardiomyopathy by speckle‐tracking imaging

Minciună

Orășan

Minciună

et al. 2021

Eur J Clin Investigation

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“…Grade III: tibial CMAP lowering (2-5 mV), which demonstrates a failure of muscle strength maintenance mechanism at the most distal site, or sural SNAP severe lowering (< 2 µV) which reflects highly decreased density of myelinated nerve fibres around the ankle. Grade IV: tibial CMAP severe lowering (< 2 mV) which presents the elimination of motor units or abolition of motor nerve fibre around foot (18,19).…”

Section: Assessment Of Diabetic Polyneuropathymentioning

confidence: 99%

Small Fibre Neuropathy Is Associated With Impaired Vascular Endothelial Function in Patients With Type 2 Diabetes

et al. 2021

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Diabetic polyneuropathy (DPN) and endothelial dysfunction are prevalent complications of diabetes mellitus. Currently, there are two non-invasive markers for endothelial dysfunction: flow-mediated dilation and reactive hyperaemia peripheral arterial tonometry (RH-PAT). However, the relationship between diabetic small fibre neuropathy and macroangiopathy remains obscure thus far. Corneal confocal microscopy (CCM) has emerged as a new diagnostic modality to assess DPN, especially of small fibre. To clarify the relationship between diabetic small fibre neuropathy and vascular dysfunction, we aimed to determine the functions of peripheral nerves and blood vessels through clinical tests such as nerve conduction study, coefficient of variation in the R-R interval, CCM, and RH-PAT in 82 patients with type 2 diabetes. Forty healthy control subjects were also included to study corneal nerve parameters. Correlational and multiple linear regression analyses were performed to determine the associations between neuropathy indices and markers for vascular functions. The results revealed that patients with type 2 diabetes had significantly lower values for most variables of CCM than healthy control subjects. RH-PAT solely remained as an explanatory variable significant in multiple regression analysis for several CCM parameters and vice versa. Other vascular markers had no significant multiple regression with any CCM parameters. In conclusion, endothelial dysfunction as revealed by impaired RH-PAT was significantly associated with CCM parameters in patients with type 2 diabetes. This association may indicate that small fibre neuropathy results from impaired endothelial dysfunction in type 2 diabetes. CCM parameters may be considered surrogate markers of autonomic nerve damage, which is related to diabetic endothelial dysfunction. This study is the first to report the relationship between corneal nerve parameter as small fibre neuropathy in patients with type 2 diabetes and RH-PAT as a marker of endothelial dysfunction.

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